The Buck Institute for Age Research is launching a new scientific discipline called Geroscience, which will be focused on the interface of normal aging and age-related disease. A five-year $25 million dollar grant from the National Institutes of Health (NIH) Roadmap for Medical Research will establish an Interdisciplinary Research Consortium in Geroscience at the Institute.
Combined exposure to environmental toxics accelerate age-related development of Parkinson's disease in mice. The Buck Institute study highlights the role of environmental factors in the the most common form of the disease.
Buck Institute faculty leads study showing "genetic fingerprints" becoming younger in healthy seniors who did resistance training. The study involved before and after analysis of gene expression profiles in tissue samples taken from 25 healthy older men and women who underwent six months of twice weekly resistance training, compared to a similar analysis of tissue samples taken from younger healthy men and women.
Researchers from four organizations have identified more than 200 new proteins that bind to normal and mutant forms of the protein that causes Huntington's disease (HD). Buck Institute faculty leads large scale screening of protein interactions to identify drug targets for possible treatment of incurable neurodegenerative disease.
An unprecedented screening of up to 120,000 chemical compounds for lifespan extension will get underway at the Buck Institute for Age Research. The results of the work, which will involve yeast, nematode worms, fruit flies and mice, will be made public, providing a valuable resource for scientists studying the aging process.
Using a mouse model of Parkinson's disease, scientists at the Buck Institute have shown for the first time that neurons associated with PD die due to inflammation. The study also shows that treatment with anti-inflammatory drug minocycline, reduced neuronal death in these mice.
Mice genetically engineered to overproduce the protein neuroglobin suffer 30 percent less tissue damage following strokes, and 25 percent less damage following heart attacks, when compared to normal mice.
It appears the human brain attempts to heal itself by giving birth to new neurons following a stroke. This finding, by scientists at the Buck Institute for Age Research, confirms similar studies in animal models and offers new targets for therapeutics to aid stroke recovery.
Aging -- a random affair? A study by Buck faculty provides first molecular evidence that some aspects of aging are likely out of our control.
Neonatal mice fed the equivalent amount of iron used in human infant formula develop Parkinson's-like neurodegeneration as they age.
A Buck Institute study provides a startling new look at Alzheimer's disease, based on research involving a newly discovered molecular pathway. Mice have senile plaques, but no symptoms of the disease.
A study shows the use of a well-known human growth factor promotes new neuron growth and a longer lifespan in mice with Huntington's disease. This finding shows potential for a new avenue of treatment for an incurable, hereditary brain disorder.
RSS
Medicine keyboard_arrow_right
Sciencekeyboard_arrow_right
Life keyboard_arrow_right
Business keyboard_arrow_right
Journal News keyboard_arrow_right
By Location keyboard_arrow_right
Meetings, Grants, and Events keyboard_arrow_right