University of Utah Health scientists are testing a new contraceptive gel for men. Based on preliminary research, the scientists believe the hormonal gel decreases a man’s sperm production––reducing his chances of fathering a child––without decreasing his sex drive.
Wistar announces the initiation of a Phase 2 clinical study of VK-2019 in patients with advanced Epstein-Barr Virus (EBV)-positive nasopharyngeal carcinoma (NPC) and lymphoma.
With an $8 million grant from the National Institutes of Health (NIH), the next stage of the THINKER project — called THINKER-NEXT — will aim to provide a comprehensive view of the risks and benefits of transplanting HCV-infected kidneys into non-infected patients.
Washington University School of Medicine in St. Louis is launching an international clinical trial aimed at preventing Alzheimer’s disease in people genetically destined to develop the illness at a young age. Unlike most other Alzheimer’s prevention trials, this one will enroll people before the disease has taken hold – up to 25 years before the expected onset of dementia.
The National Institute of Allergy and Infectious Diseases awarded researchers at the Duke Human Vaccine Institute a contract that enables it to compete for projects advancing investigational vaccines to production for use in early clinical trials.
A highly anticipated clinical trial in eight sub-Saharan countries is the first to specifically evaluate the efficacy of a COVID-19 vaccine in people living with HIV, including those with poorly controlled infections. It also is the first study to evaluate the efficacy of vaccines – in this case, Moderna mRNA-1273 – against the omicron variant of SARS-CoV-2, the virus that causes COVID-19.
Research underway at Rutgers Cancer Institute of New Jersey will contribute to the development of new cancer treatments that are based on the administration of cancer-fighting immune cells to patients.
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Human trials are set to begin for two next-generation COVID-19 vaccines developed by a team of scientists at McMaster University.
Using high-frequency waves, the new treatment pushes smaller stones from the bottom of the kidney toward the ureter. The procedure allows for an office visit instead of surgery.
Fox Chase Cancer Center has opened an investigator-initiated, phase 1 clinical trial to evaluate the safety and efficacy of gamitrinib in patients with advanced cancer.
Researchers at Penn State College of Medicine are seeking volunteers from across the U.S. to participate in a clinical trial examining whether online mindfulness-based stress reduction can reduce stress and average blood sugar levels in those with Type 1 or Type 2 diabetes.
This study may change the way we manage patients with moderate aortic stenosis and save lives.
A novel study — led by University of California San Diego and UCLA, in collaboration with the La Jolla Institute for Immunology — is assessing whether medicinal mushrooms and Chinese herbs provide therapeutic benefit in treating acute COVID-19 infection.
A world first drug developed by University of South Australia scientists may provide the critical breakthrough for 500,000 people diagnosed with pancreatic cancer.
Rutgers New Jersey Medical School’s Research with a Heart is recruiting participants for the MERCK– IMPOWER studies to assess an HIV prevention oral medication on sexual minority groups.
Researchers leading the Tau Nex Gen Trial — a worldwide clinical trial aimed at finding treatments for Alzheimer’s disease — are modifying an arm of the trial to target two brain proteins: amyloid and tau. A part of DIAN-TU, the trial originally was announced with a focus on drugs that target tau.
A promising new therapy for mesothelioma and metastatic cancer, arising from laboratory investigations at the University of Vermont Cancer Center, is about to enter a Phase I clinical trial. he approach, published in PLOS ONE, targets a universal vulnerability in cancer cells that could be exploited therapeutically.
USC Norris Comprehensive Cancer Center launches global clinical trial testing potential therapy for aggressive type of breast cancer.
Early data from a biomarker-driven Phase I trial of ATR inhibitor RP-3500 shows encouraging results for patients with advanced solid tumors harboring selected molecular alterations
A clinical trial investigating whether high-dose vitamin D3 supplements combined with a multivitamin could effectively prevent cluster headaches is now recruiting patients at The University of Texas Health Science Center at Houston (UTHealth Houston).
A University of Miami Miller School of Medicine urologist was awarded a significant R01 grant from the National Institutes of Health (NIH) for a first-of-its-kind study for treating erectile dysfunction using a combination of platelet-rich plasma and shockwave therapy.
A primary analysis of an experimental HIV vaccine regimen being studied in a high-incidence population of young women in sub-Saharan Africa found the experimental vaccine did not provide sufficient protection against HIV infection.
From bench to bedside, the journey towards new cancer therapies is full of challenges. Clinical trials – where new treatments are tested on people – are vital, but with fewer than five percent of cancer patients participating worldwide, it’s a long road to travel.
A Michigan Medicine physician will co-lead a NIH study of antibody response to an additional dose of the COVID-19 vaccine in people with autoimmune disease. The trial will also assess whether pausing immunosuppressive medication improves immune response to the booster shot.
Hackensack Meridian Hackensack University Medical Center’s Center for Memory Loss & Brain Health has started enrollment for a clinical trial for ATH-1017, an investigational medication for the treatment of mild to moderate Alzheimer’s disease as of August 3, 2021.
August 16, 2021 – Chulalongkorn Memorial Hospital, Thai Red Cross Society, and the Vaccine Research Center, Faculty of Medicine, Chulalongkorn University (CVRC) held a press conference on the progress of clinical trials for the Thai “ChulaCov19” mRNA vaccine. The clinical trial (Phase 1) was administered in healthy volunteers who are found to have good immunity after they have been vaccinated. The volunteers’ antibodies have been greatly boosted to prevent the original strain of the virus, and four other variants, namely Alpha, Beta, Gamma, and Delta. Manufacturing and preparation for registration to be used in an emergency are underway.
Hackensack Meridian Hackensack University Medical Center, Center for Memory Loss and Brain Health will be participating in a multicenter clinical trial to study the safety and efficacy of escitalopram, an antidepressant, for the treatment of agitation related to Alzheimer’s disease. This study is sponsored by the National Institute on Aging. Johns Hopkins University is the principal site and Hackensack University Medical Center will begin enrolling patients in the study starting in September 2021.
Wellcome Trust has provided a grant to the National University of Singapore to establish the Asian Clinical Research Network to conduct antimicrobial clinical research to develop the most effective ways to treat and prevent life-threatening drug-resistant infections. This will be the first clinical trial network established in Asia focusing on drug-resistant infections.
Building on its success with previous COVID-19 vaccine studies, the University of Kentucky has been selected as a site for a trial to assess dose levels of a Johnson & Johnson booster shot.
A study led by the Duke Clinical Research Institute has expanded its testing platform to evaluate three repurposed medications in the search for effective, safe treatments for mild-to-moderate COVID-19. Repurposed medications are those already approved by the U.S. Food and Drug Administration for other indications.
People living in the South, known as the Stroke Belt, are not only at a greater risk of having strokes, but the region is also associated with higher stroke mortality. The link between high blood pressure and stroke is well-known, and lowering blood pressure reduces stroke risk. But how can blood pressure be most effectively managed among stroke survivors, and is the use of telehealth the most effective strategy?
Chula Pharmacy prepares to test “Baiya Vaccine” a Thai vaccine against COVID–19 by “Baiya Phytofarm“, a Chula startup. The vaccines have been produced at the first plant in Asia that manufactures plant–based vaccines for humans. Clinical trials with volunteers and the research for the second–generation vaccine to fight the virus variants are to commence in September 2021.
Individuals with severe tricuspid valve regurgitation, in which the valve between the two right heart chambers closes incorrectly, may be eligible for a new clinical trial to treat the condition.
A recently launched Phase IIb randomized clinical trial, led by Sunjay Kaushal, MD, PhD, at Ann & Robert H. Lurie Children’s Hospital of Chicago, uses donor stem cells injected into the patient’s heart during surgery, which is expected to improve right ventricular function of children born with a congenital heart disease called hypoplastic left heart syndrome. Based on a decade of Dr. Kaushal’s pioneering lab research, clinical experience in adults and positive safety results in the Phase I trial, this stem cell-based strategy promises to extend life expectancy for these children.
UChicago Medicine’s Stroke and Neurocritical Care teams will be participating in a global research study to learn if an experimental drug saves lives and brain function by stopping the bleeding in the brains of patients suffering from a type of stroke called an intracerebral hemorrhage.
Researchers at UC San Diego Health have launched a pair of clinical trials to study the immune response of COVID-19 vaccinated transplant recipients of bone marrow and solid organs, such as the heart, lung, liver and kidney.
Vanderbilt University Medical Center (VUMC) is enrolling volunteers ages 12-69 to take part in an NIH funded study to assess reactions to the Pfizer and Moderna COVID-19 vaccines in highly allergic individuals.
The Prevent COVID U study, which launched in late March 2021 to evaluate SARS-CoV-2 infection and transmission among university students vaccinated with the Moderna COVID-19 Vaccine, has expanded beyond the university setting to enroll young adults ages 18 through 29 years and will now also include people in this age group who choose not to receive a vaccine.
On June 14, 2021 at Bhumisirimangalanusorn Building, Chulalongkorn Memorial Hospital, the Thai Red Cross Society, the Faculty of Medicine and the Chula Vaccine Research Center (CVRC), Faculty of Medicine, Chulalongkorn University conducted its first phase of clinical trial on volunteers who have passed the screening process and deemed to be in good health. The process is continuing on to phase 2 to monitor immunity reactions to the ChulaCov19 vaccine under the supervision of medical experts, doctors, nurses and the research team.
Atlantic Health System Cancer Care physicians are lead or co-authors of seven original studies to be presented and published at the 2021 ASCO Annual Meeting, held virtually June 4-8. The ASCO annual meeting is the world’s leading venue for presenting original clinical research on cancer.
New treatment could help people with phenylketonuria (PKU), a genetic disorder that prevents people from metabolizing phenylalanine. Newborns are tested for PKU, which, if not diagnosed early, can have devastating effects. Patients with PKU follow a specific diet for most of their lives.
Researchers at Penn State College of Medicine are participating in a national clinical trial evaluating whether people who have previously experienced severe allergic reactions are at increased risk for an immediate, systemic allergic reaction to the Moderna or Pfizer-BioNTech COVID-19 vaccines.
To mark Clinical Trials Day on May 20, the Pulmonary Fibrosis Foundation (PFF) aims to herald the positive impact clinical trials have made on the pulmonary fibrosis (PF) community, the current advancements in research and the importance of patient involvement.
Dr. Suzette Sutherland is involved in three clinical trials designed to make urinary incontinence more manageable, using the technique of neuromodulation with small devices which can be managed by patient.
Researchers at UC San Diego School of Medicine have begun a pilot clinical trial to test the efficacy of using ultrasound to stimulate the spleen and reduce COVID-19-related inflammation, decreasing the length of hospital stays.
Now open for applications, Argonne’s Margaret Butler Fellowship in Computational Science offers an opportunity for one postdoc to work at the forefront of scientific computing at the Argonne Leadership Computing Facility.
A single intranasal dose of a COVID-19 vaccine candidate created by Altimmune Inc. provides sterilizing immunity in the lungs of vaccinated animals. In contrast, non-vaccinated animals showed dense pulmonary infection and disease following infection with the virus that causes COVID-19.
Rutgers has been selected as a clinical trial site for the global Pfizer-BioNTech research study to evaluate the efficacy of its COVID-19 vaccine in children ages 6 months to 11 years. This is the third time Rutgers has served as a COVID-19 vaccine clinical trial site for pharmaceutical companies. Last fall, it conducted trials for Moderna and Johnson & Johnson.
Researchers at the University of Maryland School of Medicine began enrolling children ages 6 months to 11 years old in a clinical trial of the Moderna mRNA-1273 COVID-19 vaccine, which has already received Food and Drug Administration Emergency Use Authorization for adults.
David Goldberg, M.D., M.S.C.E., associate professor of medicine in the Division of Digestive Health and Liver Diseases at the University of Miami Miller School of Medicine, is one of three principal investigators of a five-year, $7.8 million National Institutes of Health-funded study using donor kidneys infected with hepatitis C (HCV) in patients awaiting kidney transplants who do not have HCV.
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