Electronic nudges delivered to health care clinicians based on a machine learning algorithm that predicts mortality risk quadrupled rates of conversations with patients about their end-of-life care preferences, according to the long-term results of a randomized clinical trial published by Penn Medicine investigators in JAMA Oncology today.
CAR T cell therapy may enhance the effectiveness of surgery for solid tumors, according to a preclinical study from researchers in the Perelman School of Medicine at the University of Pennsylvania.
Twenty-seven Penn Medicine employees and medical students recently received Penn Medicine CAREs grants for projects designed to improve wellbeing, health equity, and inclusion in the region’s most diverse and underserved populations. In addition, HopePHL was selected as the Penn Medicine CAREs Community Champion for 2022.
Penn Medicine has received a $9.7 million grant from The Warren Alpert Foundation (WAF) that will fund continuing education efforts for genetic counselors, to ensure opportunities for continued training that will keep them on the leading edge of their profession interpreting genomic data and explaining its implications to patients.
Penn Medicine has partnered with the Howley Foundation and La Salle University to launch the ASPIRE Program at the Hospital of the University of Pennsylvania (HUP), marking an important investment in the future of nursing.
The Penn Transplant Institute at Penn Medicine has opened a new Center for Living Donation which will expand Penn’s exceptional care for living donors, helping to maximize the number of lives saved through liver and kidney transplantation. For the thousands waiting on a lifesaving organ, living donation—when a living person donates an organ, or part of an organ, for transplantation to another person—can help those in need receive life-saving care sooner.
The U.S. Food and Drug Administration has approved the targeted imaging agent Cytalux (pafolacianine) for use in lung cancer surgery. This injectable diagnostic binds to cancerous tissue and glows when stimulated by near-infrared light, making it easier for surgeons to remove tumors completely while sparing healthy tissue. Thoracic surgeons at the Center for Precision Surgery in the Abramson Cancer Center at Penn Medicine led the clinical trials evaluating the imaging agent in lung cancer, in a partnership with On Target Laboratories.
A first-of-its-kind drug known as modakafusp alfa has shown early potential in combating multiple myeloma, a form of bone marrow cancer, in a study presented by researchers from the University of Pennsylvania’s Abramson Cancer Center at the 2022 American Society of Hematology (ASH) Annual Meeting (Abstract 565).
Researchers from the University of Pennsylvania’s Abramson Cancer Center presented preliminary results of an ongoing Phase I clinical trial demonstrating successful re-treatment with CAR T cell therapy for patients whose cancers relapsed after previous CAR T therapy at the 2022 American Society of Hematology (ASH) Annual Meeting (Abstract 2016).
Researchers from the Abramson Cancer Center and Perelman School of Medicine at the University of Pennsylvania will be presenting data on the latest advances in blood cancer research and treatment at the 2022 American Society of Hematology (ASH) Annual Meeting from December 10-13.
A small molecule inhibitor that attacks the difficult to target, cancer-causing gene mutation KRAS, found in nearly 30 percent of all human tumors, successfully shrunk tumors or stopped cancer growth in preclinical models of pancreatic cancer, researchers from Penn Medicine’s Abramson Cancer Center showed.
Researchers find that the anesthetic and fast-acting antidepressant switches natural patterns of neuronal activity in the cortex of mice
Fifty-five percent of CareConnect’s patients with opioid use disorder had an active prescription for treatment a month after first engaging with the program
Penn Medicine experts have worked with local partners to improve health care in Botswana for years. Now, a new $3.5 million grant from the NCI will help further that work by addressing one of Botswana’s most serious health challenges: cervical cancer.
Researchers at the University of Pennsylvania’s Basser Center for BRCA at the Abramson Cancer Center have discovered factors that may make breast and ovarian cancers associated with BRCA1/2 gene mutations more likely to recur.
Text messages sent automatically from patients’ primary care office after hospitalization were tied to decreased odds of needing further emergency care
After showing promise in early laboratory research, the cholesterol-lowering drug fenofibrate had no significant effect on COVID-19 outcomes in a multicenter international randomized clinical trial led by Penn Medicine scientists.
Pennsylvania Hospital will team up with the American Cancer Society, the Consulate of Mexico in Philadelphia and Univision 65 to host an annual breast cancer screening event on Friday, October 28, by providing free mammograms to uninsured and underinsured women in the Philadelphia community.
The new study showed apixaban is superior to rivaroxaban against stroke or systemic embolism in patients with atrial fibrillation and valvular heart disease
Five experts from the Perelman School of Medicine at the University of Pennsylvania have been elected to the National Academy of Medicine (NAM), one of the nation’s highest honors in the fields of health and medicine. Regina Cunningham, Elizabeth Howell, Steven Joffe, Katalin Karikó, and Drew Weissman are among the 100 new members, elected by current NAM members.
Two renowned health systems are bringing the most advanced form of radiation treatment to cancer patients in South Jersey, with the creation of the Penn Medicine |Virtua Health Proton Therapy Center in Voorhees, N.J.
Thirty initiatives were supported by Penn Medicine CAREs grants this past quarter, along with programs to provide caregiver respite and encourage STEM education.
Patients’ low-light sensitivity improved by factors of thousands in a clinical trial
Telemedicine-driven program cut the time from an initial new patient visit to fertility treatment from more than two months to 41 days
A $50 million gift from Stewart and Judy Colton will accelerate the existing Colton Center for Autoimmunity at the University of Pennsylvania’s Perelman School of Medicine into an internationally leading center of autoimmune research and treatment with a dedicated space, powerful recruitment capabilities, scientific resources, and more. This gift builds on a $10 million gift from the Coltons, which established the Colton Center for Autoimmunity at Penn in the fall of 2021.
Multi-year partnership brings together two iconic organizations with shared goal of making impact on health care in the Philadelphia community
Apremilast (brand name Otezla) has helped psoriasis patients achieve clearer skin and ease the symptoms of their psoriatic arthritis. Now, new data from researchers at the Perelman School of Medicine at the University of Pennsylvania shows it could also help people with psoriasis shed unhealthy body fat and therefore improve cardiovascular health, a well-known vulnerability for those with psoriasis.
Penn Medicine researchers will help lead development of an algorithm to flag patients at risk of rare disease thanks to a $4.7 million NIH grant
Ordering and managing genomic testing in electronic health records significantly cut the time Penn Medicine clinicians spent doing it
The University of Pennsylvania’s Basser Center for BRCA at the Abramson Cancer Center today announced a $55 million gift from Penn alumni Mindy and Jon Gray to establish the Basser Cancer Interception Institute, creating a new weapon to target hereditary cancers at their earliest stages.
Bloodstream levels of a protein fragment called endotrophin can be used to predict outcomes in patients with a common form of heart failure, according to a study co-led by researchers at the Perelman School of Medicine at the University of Pennsylvania.
New commentary from experts at Penn Medicine and Children's Hospital of Philadelphia outlines how health systems can help build black wealth, including helping people connect to key services.
A small device that detects food craving-related brain activity in a key brain region, and responds by electrically stimulating that region, has shown promise in a pilot clinical trial in two patients with loss-of-control binge eating disorder (BED), according to researchers at the Perelman School of Medicine at the University of Pennsylvania.
Michele Volpe has been named the University of Pennsylvania Health System’s new Chief Operating Officer, following 23 years as CEO of Penn Presbyterian Medical Center (PPMC).
With super-resolution imaging, Penn Medicine researchers discovered that cells change the physical structure of their genome when they’re affected by disease
Aiming to advance the nation’s telehealth research agenda and improve cancer-related care and outcomes, with support from the White House Cancer Moonshot, the Perelman School of Medicine at the University of Pennsylvania is one of four institutions nationally to receive a five-year, $5.7 million grant from the National Cancer Institute (NCI), part of the National Institutes of Health, for a new research center to develop and test advanced methods of telehealth delivery for cancer care with a focus on promoting health equity.
Data published in Cell Metabolism on liver cancer’s rapid growth which leads to a vulnerability in its energy-production and cell-building processes that may be potently exploited with a new combination-treatment strategy, according to a study from researchers at the Perelman School of Medicine at the University of Pennsylvania.
Penn Medicine hospitals have once again been ranked among the top in the nation by U.S News & World Report. The combined enterprise of the Hospital of the University of Pennsylvania and Penn Presbyterian Medical Center is ranked #13 in the nation for the second year in a row, and appear on the magazine’s prestigious annual Honor Roll for the 16th consecutive year. HUP/PPMC is also ranked as the top hospital in Pennsylvania and #1 in the Philadelphia metro area in the 2022 survey. Lancaster General Hospital also garnered impressive honors, again ranking #4 in Pennsylvania.
Medication therapy based on the hormone glucagon-like peptide-1(GLP-1) may help regulate natural insulin production in cystic fibrosis, potentially offering a better way to prevent and ultimately manage diabetes than daily insulin injections
A new study of data from Chicago found that the neighborhoods where violent crime fell the most, cardiovascular disease mortality fell sharply, too
New research shows that parents are open to talking about gun safety measures with their children’s pediatricians and willing to change firearm storage practices
Building on Penn Medicine’s years of research and use of imaging technology that illuminates tumor tissue—helping clinicians more easily detect and remove it—the Perelman School of Medicine at the University of Pennsylvania has received a five-year, $9 million research grant from the National Cancer Institute (NCI) to push the field forward, particularly for lung cancer patients.
The historic scientific breakthrough at the Perelman School of Medicine at the University of Pennsylvania that helped lead the world’s fight against COVID-19 through mRNA-based vaccines is being commemorated through a non-fungible token—a digital asset to be auctioned by Christie’s—that will support ongoing research at Penn.
Over the last 10 years, the Penn Medicine CAREs grant program has supported staff, faculty, students, and trainees across the organization in helping their communities. This quarter, 36 community programs received funding.
New understanding of protein function also has implications for immunotherapies
The Pew Charitable Trusts has named Maayan Levy, PhD, an assistant professor of Microbiology at the Perelman School of Medicine at University of Pennsylvania, a 2022 Pew Scholar in the Biomedical Sciences. The Pew Charitable Trusts and the Alexander and Margaret Stewart Trust have also selected Alexander Huang, MD, an assistant professor of Hematology-Oncology, and Chengcheng Jin, PhD, an assistant professor of Cancer Biology, as 2022 Pew-Stewart Scholars for Cancer Research. John James Tello Cajiao, PhD, a postdoctoral fellow in Pathology & Laboratory Medicine, has been named a 2022 Pew Latin American Fellow in the Biomedical Sciences.
A study examining pain and prescription use among hip fracture patients compared outcomes among those who had spinal anesthesia and those who had general anesthesia
While automated texting did not get more patients to get their vaccinations against COVID-19, it reached roughly the same amount as manned phone calls
A stress protein that is overactive in many types of tumor cells also has a key role in tumor-supporting cells called fibroblasts, and may be a good target for future cancer treatments, suggests a study from researchers at the Perelman School of Medicine at the University of Pennsylvania.
Penn Medicine will offer free cancer screenings and risk assessments on Sunday, June 12 at a local health fair in Southwest Philadelphia at the William C. Bryant Promise Academy, 6001 Cedar Avenue, Philadelphia, PA 19143., and mammographies from Jun 12 - 24, weekdays, for free, no insurance required, same location.
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