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31-May-2017 5:00 PM EDT
Perseverance Pays Off in Fight Against Deadly Lassa Virus
Scripps Research Institute

This story starts with a young graduate student in San Diego and leads all the way to Sierra Leone, to a unique hospital where Lassa fever victims arrive by the thousands every year.

Released: 31-May-2017 1:05 PM EDT
Scripps Florida Scientist Wins $2 Million Grant to Study Childhood Disorder Linked to Behavioral Problems
Scripps Research Institute

Assistant Professor Seth Tomchik of the Florida campus of The Scripps Research Institute (TSRI) has received $2 million in funding from the National Institutes of Health’s National Institute of Neurological Disorders and Stroke (NINDS). The new five-year grant funding will support the study of neurofibromatosis type I, an inherited disorder that results from genetic mutations affecting a protein called neurofibromin (Nf1).

     
Released: 30-May-2017 11:05 AM EDT
The Scripps Research Institute Appoints Alexandria Real Estate Equities, Inc. CEO Joel Marcus to Board of Directors
Scripps Research Institute

The Scripps Research Institute (TSRI), one of the world's largest, private, non-profit research organizations, today announced the appointment of Joel S. Marcus to its Board of Directors.

   
26-May-2017 3:00 AM EDT
New Antibiotic Packs a Punch Against Bacterial Resistance
Scripps Research Institute

Scientists at The Scripps Research Institute (TSRI) have given new superpowers to a lifesaving antibiotic called vancomycin, an advance that could eliminate the threat of antibiotic-resistant infections for years to come.

   
Released: 26-May-2017 9:05 AM EDT
Scientists Jump Hurdle in HIV Vaccine Design
Scripps Research Institute

Scientists at The Scripps Research Institute (TSRI) have made another important advance in HIV vaccine design.

   
Released: 24-May-2017 2:05 PM EDT
Zika Reached Miami at Least Four Times, Caribbean Travel Likely Responsible
Scripps Research Institute

With mosquito season looming in the Northern Hemisphere, doctors and researchers are poised to take on a new round of Zika virus infections. Now a new study by a large group of international researchers led by scientists at The Scripps Research Institute (TSRI) explains how Zika virus entered the United States via Florida in 2016—and how it might re-enter the country this year.

   
Released: 24-May-2017 12:00 PM EDT
TSRI Scientists Find Simple Copper Complex Shuts Down Botulinum Neurotoxin Poisoning
Scripps Research Institute

Clostridium botulinum is the bacterium that causes the neurointoxication, which produces one of the most potent toxins on earth and is classified as a potential bioterrorism threat. While no cure exists—and botulism treatment options are limited—a serendipitous discovery by scientists at The Scripps Research Institute (TSRI) may provide a new therapy that can stop the neurotoxin even in its more severe, advanced stages of action.

   
Released: 11-May-2017 12:05 PM EDT
Why One Eye-Targeting Virus Could Make for a Useful Gene-Delivery Tool
Scripps Research Institute

In their quest to replicate themselves, viruses have gotten awfully good at tricking human cells into pumping out viral proteins. That’s why scientists have been working to use viruses as forces for good: to deliver useful genes to human cells and help patients who lack important proteins or enzymes. A team of researchers led by Associate Professor Vijay Reddy at The Scripps Research Institute (TSRI) has now uncovered the structural details that make one virus a better tool for future therapies than its closely related “cousin.”

   
Released: 9-May-2017 1:05 PM EDT
Three San Diego Researchers Honored by Royal Society of Chemistry
Scripps Research Institute

Three chemists from The Scripps Research Institute (TSRI)—Dale Boger, Jin-Quan Yu and Phil Baran—have received awards from the Royal Society of Chemistry (RSC), a renowned professional organization for chemists based in the United Kingdom, with more than 54,000 members worldwide.

Released: 4-May-2017 12:05 PM EDT
Scientists Solve Major Cancer Protein Conundrum
Scripps Research Institute

Despite intense research, there’s been much confusion regarding the exact role of a protein in a critical cancer-linked pathway. On one hand, the protein is described as a cell proliferation inhibitor, on the other, a cell proliferation activator, a duality that has caused a great deal of scientific head scratching. Now scientists from the Florida campus of The Scripps Research Institute (TSRI) have solved the conundrum, uncovering the regulatory machinery underlying the function of a protein, called angiomotin.

Released: 2-May-2017 12:05 PM EDT
At Last, a Clue to Where Cancer Metastases Are Born
Scripps Research Institute

Scientists at The Scripps Research Institute (TSRI) have discovered why some cancers may reoccur after years in remission.

   
Released: 25-Apr-2017 3:05 PM EDT
Scientists Unravel How Protein Impacts Intellectual Disability
Scripps Research Institute

Scientists from the Florida campus of The Scripps Research Institute (TSRI) have shown that a protein helps balance nerve cell communication.

Released: 19-Apr-2017 1:45 PM EDT
Closer Look at Brain Circuits Reveals Important Role of Genetics
Scripps Research Institute

Scientists at The Scripps Research Institute (TSRI) in La Jolla have revealed new clues to the wiring of the brain. A team led by Associate Professor Anton Maximov found that neurons in brain regions that store memory can form networks in the absence of synaptic activity.

Released: 19-Apr-2017 1:05 PM EDT
Broad Advance from TSRI Chemists Dramatically Simplifies Olefin Synthesis
Scripps Research Institute

Chemists at The Scripps Research Institute (TSRI) have discovered a new method that greatly simplifies, and in many cases enables for the first time, the making of a vast range of organic molecules.

Released: 14-Apr-2017 1:05 PM EDT
TSRI Chemists Devise Simple Method for Making Sought-After Boronic Acid-Based Drugs and Other Products
Scripps Research Institute

Chemists at The Scripps Research Institute (TSRI) have developed a broad and strikingly easy method for synthesizing a class of molecules that have demonstrated value as pharmaceuticals.

   
Released: 12-Apr-2017 12:30 PM EDT
Surprising Brain Change Appears to Drive Alcohol Dependence
Scripps Research Institute

A new study led by scientists at The Scripps Research Institute (TSRI) could help researchers develop personalized treatments for alcoholism and alcohol use disorder.

   
Released: 11-Apr-2017 11:00 AM EDT
Scripps Florida Scientist Awarded $4.8 Million to Bring HIV Vaccine Closer to Human Trials
Scripps Research Institute

Professor Michael Farzan, co-chair of the Department of Immunology and Microbiology on the Florida campus of The Scripps Research Institute (TSRI) has received $4.8 million in funding through a 2017 Avant-Garde Award for HIV/AIDS research from the National Institutes of Health’s National Institute on Drug Abuse (NIDA). The new funding will support a five-year project, led by Farzan, to bring a potential HIV vaccine closer to human clinical trials.

   
Released: 10-Apr-2017 3:05 PM EDT
New Approach Makes Cells Resistant to HIV
Scripps Research Institute

Scientists at The Scripps Research Institute (TSRI) have found a way to tether HIV-fighting antibodies to immune cells, creating a cell population resistant to the virus.

   
3-Apr-2017 11:25 AM EDT
The Scripps Research Institute (TSRI) Expands New Board of Directors with the Appointment of Yucaipa Companies Founder and Philanthropist Ron Burkle
Scripps Research Institute

The Scripps Research Institute (TSRI), one of the world's largest, private, non-profit research organizations, today announced the appointment of Ronald W. Burkle to its Board of Directors—adding another world-renowned business leader and philanthropist to its newly restructured board.

   
Released: 31-Mar-2017 12:05 PM EDT
Experimental Small Molecule Shows Potential in Preventing Meth Relapse
Scripps Research Institute

New research from The Scripps Research Institute (TSRI) suggests that the reason methamphetamine users find it so hard to quit—88 percent of them relapse, even after rehab—is that meth takes advantage of the brain’s natural learning process.

Released: 28-Mar-2017 2:05 PM EDT
TSRI Researchers Develop New Method to ‘Fingerprint’ HIV
Scripps Research Institute

Scientists at The Scripps Research Institute (TSRI) have developed a method to analyze the glycan shield on HIV’s protective outer glycoprotein, developed as a potential HIV vaccine candidate.

Released: 28-Mar-2017 12:05 PM EDT
A Molecular On/Off Switch for CRISPR
Scripps Research Institute

TSRI Scientists Reveal How Viruses Disable Bacterial Immune Systems

Released: 27-Mar-2017 1:05 PM EDT
Scientists Discover New Class of Anti-Diabetes Compounds That Reduce Liver Glucose Production
Scripps Research Institute

A team of scientists from the Florida campus of The Scripps Research Institute (TSRI), Dana-Farber Cancer Institute, Harvard Medical School and the Yale University School of Medicine, among others, have identified a new class of compounds that reduce production of glucose in the liver.

Released: 27-Mar-2017 1:05 PM EDT
Mobile Technology Shakes Up Pregnancy Research
Scripps Research Institute

Current pregnancy recommendations don’t work for everyone. Researchers at TSRI and STSI aim to change that.

Released: 20-Mar-2017 11:05 AM EDT
Researchers Discover Key to Drug Resistance in Common Breast Cancer Treatment
Scripps Research Institute

Scientists from the Florida campus of The Scripps Research Institute (TSRI), the University of California (UC), San Diego and the University of Illinois have found that two immune system molecules may be key to the development of drug resistance in estrogen-driven breast cancers.

Released: 16-Mar-2017 2:05 PM EDT
Scripps Florida Scientists Develop New Drug Delivery Method for Cancer Therapy
Scripps Research Institute

Scientists from the Florida campus of The Scripps Research Institute (TSRI) have developed a new drug delivery method that produces strong results in treating cancers in animal models, including some hard-to-treat solid and liquid tumors.

Released: 9-Mar-2017 1:05 PM EST
Potential Drug Candidates Halt Prostate and Breast Cancer Growth
Scripps Research Institute

Scientists on the Florida campus of The Scripps Research Institute (TSRI) have designed two new drug candidates to target prostate and triple negative breast cancers.

Released: 8-Mar-2017 1:05 PM EST
In Battle for Real Estate, a Disordered Protein Wins Out
Scripps Research Institute

New TSRI Study Points to Potential Strategy to Kill Cancer Cells

6-Mar-2017 1:00 PM EST
New Enzyme-Like Tool Lets Chemists Modify Hard-to-Reach Spots on Drug Molecules
Scripps Research Institute

Chemists at The Scripps Research Institute (TSRI) have devised a versatile molecule-building tool for creating new drugs and other chemical products.

   
Released: 6-Mar-2017 1:05 PM EST
Fighting Blindness: TSRI Scientists Bring a Key Protein Into Focus
Scripps Research Institute

Scientists from the Florida campus of The Scripps Research Institute (TSRI) have discovered how a protein called α2δ4 establishes proper vision.

Released: 28-Feb-2017 2:05 PM EST
Watching the Clock: Biologist Katja Lamia Investigates Circadian Rhythms
Scripps Research Institute

TSRI's Katja Lamia and her lab members are on a mission to understand how circadian proteins keep us healthy.

Released: 22-Feb-2017 7:05 PM EST
TSRI Researchers Find Standard Pacemakers and Defibrillators Safe for Mri Using a New Protocol
Scripps Research Institute

The MagnaSafe Registry, a new multicenter study led by scientists at The Scripps Research Institute (TSRI), has demonstrated that appropriately screened and monitored patients with standard or non-MRI-conditional pacemakers and defibrillators can undergo MRI at a field strength of 1.5 tesla without harm.

Released: 21-Feb-2017 12:05 PM EST
TSRI-Invented Compound Ozanimod Shows Positive Results in Late-Stage Clinical Trial for Relapsing Multiple Sclerosis
Scripps Research Institute

Results from a new Phase 3 study conducted by the Celgene Corporation demonstrate that ozanimod, a drug candidate originally discovered and optimized at The Scripps Research Institute (TSRI), can reduce the frequency of multiple sclerosis relapse.

Released: 15-Feb-2017 12:05 PM EST
Scripps Florida Scientists Take Aim at Obesity-Linked Protein
Scripps Research Institute

In a study recently published online in the journal Molecular Metabolism, Chakraborty and his colleagues have shown that deleting the gene for this protein, known as IP6K1, protects animal models from both obesity and diabetes.

   
Released: 14-Feb-2017 11:05 AM EST
Scripps Florida Collaboration Awarded $3.3 Million to Develop Next-Generation Breast Cancer Therapies
Scripps Research Institute

A pair of scientists from the Florida campus of The Scripps Research Institute (TSRI) have been awarded up to $3.3 million from the National Cancer Institute of the National Institutes of Health (NIH) to create the next generation of breast cancer treatments for the thousands of patients whose current treatment options are limited.

Released: 13-Feb-2017 12:05 PM EST
TSRI Researchers Discover How the Brain Turns Chronic Stress into Pathological Anxiety
Scripps Research Institute

In a new study, researchers at The Scripps Research Institute (TSRI) have described how two important molecules in the brain work together to trigger intense anxiety.

Released: 6-Feb-2017 3:05 PM EST
Scripps Florida Scientists Find Clue to Why Zika, but Not Its Close Relatives, Causes Birth Defects
Scripps Research Institute

Scientists from the Florida campus of The Scripps Research Institute (TSRI) have uncovered the details behind the virus’s unique ability to cross the placental barrier and expose the fetus to a range of birth defects that often go beyond microcephaly to include eye and joint injury, and even other types of brain damage.

Released: 2-Feb-2017 2:05 PM EST
TSRI Chemists Unveil Versatile New Method for Making Chiral Drug Molecules
Scripps Research Institute

Chemists at The Scripps Research Institute (TSRI) have invented a new technique for constructing chiral drug molecules.

Released: 1-Feb-2017 2:05 PM EST
TSRI Scientists Show Deep Brain Stimulation Blocks Heroin Relapse in Rats
Scripps Research Institute

Scientists at The Scripps Research Institute (TSRI) have found that deep brain stimulation (DBS) can greatly reduce the compulsion to use heroin in standard rat models of addiction.

Released: 30-Jan-2017 5:05 PM EST
New TSRI Study Shows Early Brain Changes in Fragile X Syndrome
Scripps Research Institute

A new study led by scientists at The Scripps Research Institute (TSRI) is giving researchers a first look at the early stages of brain development in patients with Fragile X syndrome, a disorder that causes mild to severe intellectual disability and is the most common genetic cause of autism spectrum disorder.

Released: 27-Jan-2017 1:05 PM EST
TSRI Scientists Find Brain Hormone That Triggers Fat Burning
Scripps Research Institute

Biologists at The Scripps Research Institute (TSRI) have identified a brain hormone that appears to trigger fat burning in the gut. Their findings in animal models could have implications for future pharmaceutical development.

Released: 24-Jan-2017 11:05 AM EST
Scripps Florida Team Awarded $1.8 Million Grant to Develop Drugs for Heart Disease and Rheumatoid Arthritis
Scripps Research Institute

Scientists from the Florida campus of The Scripps Research Institute (TSRI) have been awarded approximately $1.8 million from the National Institute of General Medical Sciences of the National Institutes of Health to develop a series of drug candidates for a number of diseases, including heart disease, rheumatoid arthritis and several neurodegenerative disorders.

Released: 23-Jan-2017 4:05 PM EST
TSRI Scientists Create First Stable Semisynthetic Organism
Scripps Research Institute

Scientists at The Scripps Research Institute (TSRI) have announced the development of the first stable semisynthetic organism.

19-Jan-2017 12:00 PM EST
New TSRI Method Could Turbocharge Drug Discovery, Protein Research
Scripps Research Institute

A team led by scientists at The Scripps Research Institute (TSRI) has developed a versatile new method that should enhance the discovery of new drugs and the study of proteins.

11-Jan-2017 1:00 PM EST
TSRI Scientists Discover Master Regulator of Cellular Aging
Scripps Research Institute

Scientists at The Scripps Research Institute (TSRI) have discovered a protein that fine-tunes the cellular clock involved in aging.

   
Released: 10-Jan-2017 1:00 PM EST
TSRI Signs Collaboration Agreement with Pfizer to Advance DNA-Encoded Library Technology
Scripps Research Institute

The Scripps Research Institute (TSRI), a leading non-profit biomedical research institute, today announced a research collaboration and license agreement with Pfizer Inc. (NYSE: PFE) to pioneer new DNA-encoded library (DEL) technology, including new synthetic chemistry for the creation of next-generation DELs, a potentially transformative technology for early stage drug discovery research.

   
Released: 5-Jan-2017 1:05 PM EST
TSRI Researchers Discover Surprising Process Behind Sense of Touch
Scripps Research Institute

Biologists on the Florida campus of The Scripps Research Institute (TSRI) have discovered a new mechanism that likely underlies how we feel force or touch.

Released: 4-Jan-2017 1:05 PM EST
Scripps Florida Scientists Expand Toolbox to Study Cellular Function
Scripps Research Institute

Scientists on the Florida campus of The Scripps Research Institute (TSRI) have developed a new tool for studying the molecular details of protein structure.



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