In the journal Nature Communications, researchers report for a particular subset of lung cancer tumors, there is a high prevalence of immune cells called inflammatory monocytes. These immune cells, which normally help to build clotting scaffolds to promote wound healing, also make it possible for tumor cells to migrate and spread to other parts of the body.
In the journal Cancer Research, UNC Lineberger Comprehensive Cancer Center researchers report they have developed a model of luminal bladder cancer, one of the two subtypes of advanced bladder cancer. The researchers said this model may help them to determine which patients may respond to checkpoint inhibitors.
A new case report led by Maya Styner, MD, of the UNC School of Medicine describes how a patient's use of a common over-the-counter biotin supplement caused clinically misleading test results and almost resulted in an unnecessary, invasive medical procedure.
UNC School of Medicine researchers have delineated the details of one major barrier to a promising vaccine. It’s something we all have – a natural body temperature of about 98.6 degrees.
For the first time, UNC School of Medicine scientists led by Nobel laureate Aziz Sancar analyzed whole-genome DNA repair in an animal over 24 hours to find which genes were repaired, where exactly, and when, laying the groundwork for a more precise use of anti-cancer drugs.
A new study from the UNC Lineberger Comprehensive Cancer Center shows that parenting concerns have a significant impact on the mental and emotional health of women with advanced cancer. In particular, they found that a mother’s emotional well-being was significantly linked with whether she had communicated with her children about her illness, and her concerns about how her illness will financially impact her children.
Medical aid-in-dying is now legal in eight U.S. jurisdictions, but patients still face substantial barriers to access, according to a new analysis by Dr. Mara Buchbinder of the University of North Carolina School of Medicine.
A new meta-analysis of more than 135,000 people with major depression and more than 344,000 controls has identified 44 genomic variants, or loci, that have a statistically significant association with depression.
Research led by UNC School of Medicine student Wesley Stepp, PhD, shows how more detailed genetic testing of head and neck tumors could lead to more personalized treatments for patients.
In the journal Nature Biomedical Engineering, UNC Lineberger Comprehensive Cancer Center researchers and colleagues report they have developed tissue-engineered models for cancer metastases that reflect the microenvironment around tumors that promotes their growth. They believe their models, which were developed to study colorectal cancer that had spread to the liver and lung, will help scientists studying why cancers tend to spread to certain organs rather than others.
UNC Lineberger Comprehensive Cancer Center researchers surveyed 2,664 young adults who were current users, never users, or past users of little cigars and cigarillos, finding cigarillo packs with colors and containing a flavor descriptor were rated more positively for taste and smell, and warnings didn’t fully mitigate the draw of the packaging.
UNC School of Medicine scientists led by Nikolay Dokholyan add to evidence that small aggregates of SOD1 protein are the brain-cell killing culprits in ALS, but the formation of larger, more visible, and fibril-like aggregates of the same protein may protect brain cells.
UNC Health Care has achieved Stage 7 designation – the highest rank possible – for hospitals, outpatient practices, and advanced analytics from HIMSS Analytics, a global healthcare research advisory firm. The Stage 7 honors confirm UNC Health Care’s place as a national leader in health IT and analytics.
In preliminary findings presented at the American Association for Cancer Research Annual Meeting 2018, researchers from the lab of UNC Lineberger Comprehensive Cancer Center member Stephen Hursting, PhD, reported on a number of studies examining possible ways to reverse obesity-linked biological changes.
UNC Lineberger Comprehensive Cancer Center researchers and their collaborators are reporting preclinical findings for a potential two-treatment strategy to block multiple mechanisms of cancer cell metabolism in pancreatic cancer at the American Association for Cancer Research Annual Meeting in Chicago. The findings will be presented from 8 a.m. to noon on Wednesday.
University of North Carolina at Chapel Hill Lineberger Comprehensive Cancer Center experts are available to provide expert commentary and feedback on research presented at the AACR Annual Meeting 2018.
Compared to physicians who didn’t receive any payments, those who received general payments for meals and lodging from a drug manufacturer had higher odds of prescribing that company’s particular drug for metastatic renal cell carcinoma and for chronic myeloid leukemia.
An analysis of thousands of tumors across 33 different cancer types by researchers from The Cancer Genome Atlas (TCGA) Network supports an additional classification for human tumors.
UNC School of Medicine researchers have identified mutations to the bacterium Neisseria gonnorrhoeae that enable resistance to ceftriaxone that could lead to the global spread of ceftriaxone-resistant “superbug” strains.
MRIs show that babies with fragile X syndrome had less-developed white matter compared to infants that did not develop the condition. Imaging various sections of white matter from different angles can help researchers focus on the brain circuitry important for proper neuron communication.
UNC School of Medicine researchers create a new screening technique to show that e-liquids are far from harmless to human cells and contain ingredients that can vary wildly from one type of e-cigarette to another.
This week, a 40-year-old patient was treated at UNC’s Clinical and Translational Research Center (CTRC) with SB-913, an investigational genome editing therapy for individuals with mucopolysaccharidosis type II (MPS II), a rare lysosomal storage disorder also known as Hunter syndrome.
In the journal Clinical Cancer Research, researchers reported that by forcing cancer cells to slow down and developing stronger molecular traps for them, they could identify large numbers of the cells in cancer patients undergoing radiation therapy.
University of North Carolina Lineberger Comprehensive Cancer Center researchers have identified genetic clues that explain how breast cancer spreads, or metastasizes – findings that may lead to better treatments or approaches to prevent its spread at the onset.
Researchers from the University of North Carolina Lineberger Comprehensive Cancer Center and their collaborators report they modified immune cells to hunt brain tumors displaying a new molecular target, which they determined is highly prevalent on brain cancer cells. Their preclinical studies of immune cells engineered to recognize the target showed promise for controlling tumor growth in mouse and cell models for glioblastoma.
In JCI Insight, researchers reported the results of a phase I, multi-institution clinical trial for an investigational treatment for melanoma and other cancers with mutations in the BRAF or RAS genes.
UNC and NC State scientists created an injectable gel-like scaffold that can hold combination chemo-immunotherapeutic drugs and deliver them locally to tumors in a sequential manner. The results in animal models suggest this approach could one day ramp up therapeutic benefits for cancer patients.
In this study, published in Cell Reports, two labs at UNC and a group at Princeton University reprogrammed ordinary cells called fibroblasts into new and healthy heart muscle cells, and recorded changes that appear to be necessary for this reprogramming.
The UNC School of Medicine will host a continuing professional education (CPE) symposium on March 10, 2018 in Chapel Hill to educate medical professionals on the streamlining of care for patients with Atrial fibrillation or Afib.
UNC School of Medicine researchers discovered a structure on viruses that makes them better at crossing from the bloodstream into the brain – a key factor for administering gene therapies at lower doses for treating brain and spinal disorders. Experiments also showed decreased liver toxicity.
In an effort to combat new HIV infections among men who inject drugs in Vietnam, researchers at the University of North Carolina at Chapel Hill conducted the first study to explore how this population mixes together. Their results were published in the Journal of Acquired Immune Deficiency Syndromes.
In a study published in the International Journal of Cancer, researchers analyzed health indicators for children born to young breast cancer survivors in North Carolina.
In a study published in the International Journal of Cancer, researchers analyzed health indicators for children born to young breast cancer survivors in North Carolina.
Researchers found that adolescents not susceptible to smoking cigarettes and who thought e-cigarettes were less harmful were more likely to use e-cigarettes. This UNC study found that 26 percent of those surveyed were at high risk for future e-cigarette use.
Published in Nature, research from the UNC School of Medicine and UCSF revealed the first-ever crystal structure of the dopamine 2 receptor bound to an antipsychotic drug – a much-needed discovery in the quest to create effective drugs with fewer side effects.
A study led by UNC Lineberger Comprehensive Cancer Center and published in the Journal of Cell Biology examined the role of the physical structure of the nucleus in cell movement through different surfaces.
CF researchers have now shown that the lungs’ bacterial population changes in the first few years of life as respiratory infections and inflammation set in. This research offers a way to predict the onset of lung disease and suggests a larger role for preventive therapies, such as hypertonic saline.
Recent studies testing multivalent combinations of three broadly neutralizing antibodies, or bnAbs, have yielded promising results in animal models of HIV prevention. Two investigators at the University of North Carolina at Chapel Hill describe the potential of bnAbs to inform HIV prevention, treatment and cure strategies in a recent article in the New Journal of Medicine.
Dr. Thomas Egan of the University of North Carolina School of Medicine says that a recent change in donor lung allocation policy was long overdue. However, because the change happened over the Thanksgiving holiday weekend in response to litigation, it came as a “tsunami” that was “sudden, unexpected, and may have huge consequences.”
For the first time, UNC School of Medicine scientists and collaborators solved the crystal structure of the activated kappa opioid receptor bound to a morphine derivative. They then created a new drug-like compound that activates only that receptor, a key step in the development of new pain meds.
Leslie H. Nelson has been named as President of the Medical Foundation of North Carolina and Associate Dean for Development of the UNC School of Medicine effective Jan. 1, 2018. The Medical Foundation of North Carolina is the not-for-profit, philanthropic arm of the UNC School of Medicine and UNC Hospitals.
A special cluster of proteins helps unwind DNA during cell division and plays a key role in keeping stem cells in their immature state. This UNC study also points to a better understanding of how cancer cells manage to sustain rapid cell division without triggering cell death.
Researchers analyzed the impact of one viral social media post in generating awareness about skin cancer.
Researchers present their preliminary results from the ongoing phase II trial of chemotherapy and pembrolizumab in relapsed or refractory acute myeloid leukemia at the 59th American Society of Hematology Annual Meeting in Atlanta on Saturday, Dec. 9.
Researchers report at the 59th Annual American Society for Hematology Annual Meeting in Atlanta on Saturday, Dec. 9, that they were able to validate their approach for predicting markers – called minor histocompatibility antigens – in a group of patients with blood cancers.
The biological features of patients’ tumors partially explained a racial disparity for women with hormone receptor-positive, HER2-negative breast cancer, but UNC Lineberger researchers led by Katherine Reeder-Hayes, MD, MBA, MSc, said it didn’t explain it completely. The preliminary findings were reported at the 2017 San Antonio Breast Cancer Symposium.
This UNC research shows how understanding the precise mix of bacteria and their interactions could become a standard part of clinical practice in treating bacterial infections, especially the more dangerous infections involving antibiotic resistance.
While new CF drugs are life-changing for some patients, they don’t work for everyone. Now, UNC and UAB researchers present a simple test that aims to predict which treatment is most likely to work for each patient, an approach known as personalized or precision medicine.
A grant from The Leukemia & Lymphoma Society will help fund clinical research led by UNC Lineberger's Barbara Savoldo, MD, PhD, into an investigational chimeric antigen receptor (CAR) T-cell treatment for acute lymphoblastic leukemia that would include a built-in "safety switch."
UNC School of Medicine researchers have developed a new laboratory model to measure and compare the responses of CF and normal airway cells to CF-related infectious/inflammatory factors.
RSS
Medicine keyboard_arrow_right
Sciencekeyboard_arrow_right
Life keyboard_arrow_right
Business keyboard_arrow_right
Journal News keyboard_arrow_right
By Location keyboard_arrow_right
Meetings, Grants, and Events keyboard_arrow_right