Dr. Tim Anderson at Texas Biomedical Research Institute and Dr. Phil LoVerde at the University of Texas Health Science Center at San Antonio have been awarded a $3.5 million grant over the next five years by the National Institutes of Health to understand the genetic changes in the schistosome parasite that lead to drug resistance.
HIV vaccine candidate has shown to generate more than 80% protection in groups of twelve female monkeys against high dose, repeated AIDS virus exposures during part of a preclinical study.
A recent study published in the November issue of the journal Aging showed minimal metabolic side effects after continuous, long-term treatment with encapsulated rapamycin in a marmoset (monkey) model. Research results lead to efficacy study.
In a Journal of Virology paper, Texas Biomed Scientist Dr. Anthony Griffiths, explains how he and his team found that Ebola virus has the potential to evolve rapidly but the genetic changes result in viruses that are weakened or not viable, which could be exploited as a therapeutic.
The National Institutes of Health have awarded scientists at Texas Biomedical Research Institute and collaborators at the Food and Drug Administration, UCLA and the University of Pennsylvania a $5 million grant over the next 4 years to study a combination antiviral drugs and investigative AIDS vaccines aimed at treating infants and children affected by HIV. Dr. Ruth Ruprecht, Scientist & Director of the Texas Biomed AIDS Research Program, is leading this study.
Texas Biomedical Research Institute and Wisconsin-based non-profit Take Off Pounds Sensibly® are establishing the new TOPS® Nutrition and Obesity Research Center with the goal of conducting research into the causes, health risks and treatment of human obesity.
Scientists at Texas Biomedical Research Institute have begun work on a study funded by the National Institutes of Health over the next four years to create an attenuated, or weakened, virus that is a hybrid of the papilloma virus and the human immunodeficiency virus, with the potential to jumpstart a body’s immune response to develop antibodies against both viruses.
Scientists at Texas Biomedical Research Institute in San Antonio are receiving funding from the National Institutes of Health in the form of a $2.36 million R01 grant over the next five years to focus efforts on exploring and developing a novel mechanism of Filovirus detection – using llama antibodies.
New research that focuses on the mechanism by which Ebola virus infects a cell and the discovery of a promising drug therapy candidate is being published February 27, 2015, in the journal Science.
The National Institutes of Health awarded Texas Biomedical Research Institute scientist Ian Cheeseman, over $450,000 in first-year funding and is expected to receive up to $1.8 million over four years to continue research into a new method for sequencing the genomes of individual malaria parasites.
Mymetics Corporation (OTCQB: MYMX) announced today that its innovative HIV vaccine candidate will enter a new preclinical trial to confirm results obtained in a previous trial. Research is to be funded by the Bill & Melinda Gates Foundation. The study will be led by Dr. Ruth Ruprecht, Scientist & Director of the Texas Biomed AIDS Research Program.
New research into the Crimean-Congo hemorrhagic fever virus (CCHFV), a tick-borne virus which causes a severe hemorrhagic disease in humans similar to that caused by Ebolavirus, has identified new cellular factors essential for CCHFV infection. This discovery has the potential to lead to novel targets for therapeutic interventions against the pathogen.
The Texas Biomedical Research Institute has been awarded a $2.7 million grant from the U.S. National Institutes of Health to fund innovative approaches to genetics research aimed at developing new therapies for heart disease and other conditions with genetic components.
Research conducted at the Texas Biomedical Research Institute, published in the latest issue of the scientific journal Pigment Cell and Melanoma, has established unequivocally in a natural animal model that the incidence of malignant melanoma in adulthood can be dramatically reduced by the consistent use of sunscreen in infancy and childhood.
Texas Biomedical Research Institute has recruited two new research scientists to its Southwest National Primate Research Center (SNPRC) who will focus on regenerative medicine, working with animal models to develop human stem cell therapies for medical conditions such as Parkinson's disease, degenerative diseases of the eye and muscular dystrophy.
A new method for isolating and genome sequencing an individual malaria parasite cell has been developed by Texas Biomed researchers in San Antonio and their colleagues. This advance will allow scientists to improve their ability to identify the multiple types of malaria parasites infecting patients and lead to ways to best design drugs and vaccines to tackle this major global killer.
An international group of scientists lead by Tim Anderson Ph.D., at the Texas Biomedical Research Institute and Philip LoVerde Ph.D., at the University of Texas Health Science Center at San Antonio has identified the mutations that result in drug resistance in a parasite infecting 187 million people in South America, Africa and Asia. The new finding allows detailed understanding of the drugs’ mechanism of action and raises prospects of improved therapies.
Research with baboons at the Texas Biomedical Research Institute in San Antonio may help explain why some people who take bone-strengthening drugs like bisphosphonates are at-risk for atypical fractures in the long bones in their legs.
For the first time in a large study sample, the decline in brain function in normal aging is conclusively shown to be influenced by genes, say researchers from the Texas Biomedical Research Institute in San Antonio and Yale University.
Mexican American children are experiencing substantial burdens of obesity, pre-diabetes, and other health problems which historically would have been expected to develop much later in life. The findings of a new study by Texas Biomed scientists in San Antonio argue for early screening and intervention to delay or avoid chronic health problems as these children age.
Ruth M. Ruprecht, M.D., Ph.D., a professor of medicine at Harvard Medical School and the Dana-Farber Cancer Institute in Boston, has been appointed to the position of Scientist and Director of the AIDS Research Program in the Department of Virology and Immunology at the Texas Biomedical Research Institute.
Michael Olivier, Ph.D., professor of physiology and director of the Wisconsin Center of Excellence in Genomics Science at the Medical College of Wisconsin in Milwaukee, has been appointed to the position of Scientist in the Department of Genetics at the Texas Biomedical Research Institute.
Scientists at the Texas Biomedical Research Institute in San Antonio have identified four genes in baboons that influence levels of “bad” cholesterol. This discovery could lead to the development of new drugs to reduce the risk of heart disease.
A novel drug developed by Gilead Sciences and tested in an animal model at the Texas Biomedical Research Institute in San Antonio suppresses hepatitis B virus infection by stimulating the immune system and inducing loss of infected cells.
For the first time, scientists have demonstrated the mechanism of action of gossypin, a naturally-occurring substance found in fruits and vegetables, as a treatment for melanoma, which causes the majority of deaths from skin cancer.
In the most extensive screen of its kind, Texas Biomed scientists in San Antonio have demonstrated the feasibility of repurposing already-approved drugs for use against highly pathogenic bacteria and viruses. The pathogens included emerging diseases and potential bioterror threats ranging from anthrax to the Marburg and Ebola viruses.
By screening a library of a billion llama antibodies on live Ebola viruses in the Texas Biomedical Research Institute’s highest biocontainment laboratory, scientists in San Antonio have identified a potential weakness in the make-up of these deadly agents that can immediately yield a sensitive test.
Texas Biomed scientists in San Antonio have found that moderate gum disease in an animal model exposed to an AIDS- like virus had more viral variants causing infection and greater inflammation. Both of these features have potential negative implications in long term disease progression, including other kinds of infections, the researchers say in a new report.
Scientists at the Texas Biomedical Research Institute in San Antonio have for the first time demonstrated that baboon embryonic stem cells can be programmed to completely restore a severely damaged artery. These early results show promise for eventually developing stem cell therapies to restore human tissues or organs damaged by age or disease.
The Texas Biomedical Research Institute in San Antonio has applied for a patent for a genetically-engineered vaccine strategy to prevent HIV infection that targets the outer layers of body structures that are the first sites of contact with the virus.
Texas Biomedical Research Institute scientists have developed a faster, less expensive route to screen suitable tests for bioterror threats and accelerate the application of countermeasures.
A monoclonal antibody developed by MassBiologics of the University of Massachusetts Medical School (UMMS) and tested in an animal model at the Texas Biomedical Research Institute, prevents infection by the hepatitis C virus (HCV).
Scientists at Texas Biomed have developed the laboratory opossum as a new animal model to study the most common liver disease in the nation – afflicting up to 15 million Americans – and for which there is no cure.
Emergence of resistance to the drug artemisinin in western Thailand has created a critical point in global efforts to control malaria worldwide. A second study, identifies a major region of the malaria parasite genome associated with resistance, raising hope that there will soon be effective molecular markers for monitoring the spread of resistance.
Scientists at the Texas Biomedical Research Institute and Yale University have identified a new target area in the human genome that appears to harbor genes with a major role in the onset of depression.
A surprising finding in a study comparing hepatitis C virus (HCV) with hepatitis A virus (HAV) infections in chimpanzees by a team that includes scientists from the Texas Biomedical Research Institute sheds new light on the nature of the body’s immune response to these viruses.
A research team that includes scientists from the Southwest Foundation for Biomedical Research (SFBR) reported today that inadequate nutrition during early pregnancy impairs fetal brain development. The researchers found decreased formation of cell-to-cell connections, cell division and amounts of growth factors in the fetuses of mothers fed a reduced diet during the first half of pregnancy, in baboons located at SFBR’s Southwest National Primate Research Center.
Scientists at the Southwest Foundation for Biomedical Research (SFBR) have found a gene that causes high levels of bad cholesterol to accumulate in the blood as a result of a high-cholesterol diet.
In the largest study of its kind, researchers at the Southwest Foundation for Biomedical Research (SFBR) have found that exposure to cigarette smoke can alter gene expression -- the process by which a gene's information is converted into the structures and functions of a cell. These alterations in response to smoking appear to have a wide-ranging negative influence on the immune system, and a strong involvement in processes related to cancer, cell death and metabolism.
Scientists at the Southwest Foundation for Biomedical Research (SFBR) in San Antonio have for the first time developed a highly sensitive means of detecting the seven types of botulinum neurotoxins (BoNTs) simultaneously. The finding may lead to improved techniques for testing water and food supplies should BoNTs be used as a bioterrorism weapon.
In a dramatic finding, a new drug for hepatitis C virus (HCV) infections that targets liver cells produced a substantial drop in blood levels of the virus in animals and continued to work up to several months after treatment, say scientists at the Southwest Foundation for Biomedical Research (SFBR) in San Antonio.
The Southwest National Primate Research Center (SNPRC) celebrates its 10th anniversary on October 1. The day-long program of events will include sessions on the center’s accomplishments in the areas of infectious diseases and biodefense, development and aging, chronic diseases and genomics.
Scientists at the Southwest Foundation for Biomedical Research (SFBR) in San Antonio have for the first time constructed a genetic map of the parasite that causes schistosomiasis, a chronic intestinal infection that can damage internal organs and, in children, impair growth and cognitive development.
Protection against Ebola, one of the world's deadliest viruses, can be achieved by a vaccine produced in insect cells, raising prospects for developing an effective vaccine for humans, say scientists at the Southwest Foundation for Biomedical Research (SFBR) in San Antonio.
In an unexpected result, human cancer cells injected into a new animal model act in a manner similar to the way they do in humans, and may represent a new method for understanding and treating virtually all tumors.
America faces an increase in liver cancer due to hepatitis C infections, but new treatments are on the horizon, scientists will report at the 15th International Symposium on Hepatitis C & Related Viruses, to be held in San Antonio from Oct. 5-9.
An $18.8 million federal research grant to Southwest Foundation for Biomedical Research will allow scientists to embark on several groundbreaking new studies on cardiovascular disease. Projects include searches for entire networks of genes that influence disease risk; studies on the response of endothelial cells to various risk factors; and investigations on ways to boost the body's production of stem cells that could help prevent atherosclerosis and treat heart attack victims.
With 26 years of senior management experience at several of the leading independent biomedical research institutes in the United States, Kenneth Trevett is eminently qualified to build on SFBR's track record of success and lead it to even greater achievements in its efforts to improve human health.
One of the Southwest Foundation for Biomedical Research's longest running departments is being spun off as a private, for-profit business enterprise based on the massive body of work the department has accumulated in female reproductive and related health issues.
Scientists at Southwest Foundation for Biomedical Research expect to make big leaps in their understanding of genetic influences on diabetes, as they begin detailed investigations on 100 genes they've shown to influence diabetes risk factors. Uncovering how these genes work could lead to new methods of disease prevention and treatment.
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