Patients with ascending aneurysms strongly protected from atherosclerosis
Yale School of Medicine
Two teams that include scientists from U.S. Department of Energy’s (DOE) Argonne National Laboratory have been named finalists for the Association for Computing Machinery 2023 Gordon Bell Prize. Both teams conducted groundbreaking research with the use of high performance exascale computing tools, such as Frontier, a supercomputer at DOE’s Oak Ridge National Laboratory (ORNL).
LEXINGTON, Ky. (Oct. 12, 2023) — The Herculaneum scrolls are among the most iconic and inaccessible of the world’s vast collection of damaged manuscripts. Since being burned and carbonized by the catastrophic eruption of Mt. Vesuvius in 79 CE, they’ve been deemed “unreadable.” For more than 2,000 years, wisdom from the only library to survive from ancient times remained locked away.
Plants have highly evolved mechanisms to shed or drop organs (abscission) in response to environmental or developmental cues. It’s why you have to rake leaves in the Fall! But in agriculture, the natural shedding of flowers or seeds is detrimental, and cereal crops with abscission-inhibiting mutations in certain genes, like SHATTERING1, have been bred to dramatically increase yield. Using Crispr gene editing and detailed analyses, Yu et al. show for the first time some mechanistic features of abscission in the grasses, including the role of the plant hormone auxin.
Researchers at the Beckman Institute for Advanced Science and Technology have established the protein p53 as critical for regulating sociability, repetitive behavior, and hippocampus-related learning and memory in mice, illuminating the relationship between the protein-coding gene TP53 and neurodevelopmental and psychiatric disorders.