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12-Apr-2016 3:00 PM EDT
UCLA Scientists Reveal How Osteopontin Ablation Ameliorates Muscular Dystrophy
The Rockefeller University Press

Removing an immunomodulatory protein called osteopontin improves the symptoms of mice with muscular dystrophy by changing the type of macrophages acting on damaged muscle tissue, according to a paper published in The Journal of Cell Biology. The study, “Osteopontin ablation ameliorates muscular dystrophy by shifting macrophages to a pro-regenerative phenotype” by Joana Capote and colleagues, adds support to the idea that osteopontin inhibitors could be used to treat patients with Duchenne muscular dystrophy.

   
13-Apr-2016 3:05 PM EDT
Baylor Study Reveals Oxidized Mitochondrial DNA Induces Interferon Production in Lupus Patients
The Rockefeller University Press

Researchers at the Baylor Institute for Immunology Research have discovered that the neutrophils of systemic lupus erythematosus (SLE) patients release oxidized DNA from their mitochondria that can stimulate an unwanted immune response. The study “Oxidized mitochondrial nucleoids released by neutrophils drive type I interferon production in human lupus,” which will be published online April 18 in The Journal of Experimental Medicine, suggests that targeting the pathways that lead to the accumulation of this DNA and/or facilitate its removal could be new ways to treat this chronic autoimmune disease.

4-Apr-2016 12:45 PM EDT
Face- and Eye-Muscle Research Sheds New Light on Duchenne Muscular Dystrophy
The Rockefeller University Press

Researchers at Basel University Hospital in Switzerland investigate the biochemical and physiological characteristics of orbicularis oculi, a group of facial muscles that control the eyelids and are selectively spared or involved in different neuromuscular disorders. What they found also helps to explain why another set of muscles—the extraocular muscles that control the movement of the eye—are not affected by Duchenne muscular dystrophy, congenital muscular dystrophy, and aging.

Released: 6-Apr-2016 4:05 PM EDT
How a Metabolic Pathway Promotes Breast Cancer Metastasis
The Rockefeller University Press

A metabolic pathway that is up-regulated in some breast cancers promotes the disease’s progression by activating a signaling protein called Arf6, according to a paper published in The Journal of Cell Biology. The study, “P53- and mevalonate pathway–driven malignancies require Arf6 for metastasis and drug resistance” by Ari Hashimoto and colleagues, suggests that statin-like drugs may be effective treatments for breast cancer patients whose tumors express high levels of Arf6 signaling proteins.

   
Released: 28-Mar-2016 12:00 AM EDT
“Transient Contractions” in Urinary Bladder May Lead to Therapeutic Interventions for Bladder Dysfunction
The Rockefeller University Press

Researchers at the University of Vermont College of Medicine have made a discovery on just how we know when to empty our bladders, which may have the potential to lead to new therapeutic interventions for bladder dysfunction. The study, “Transient contractions of urinary bladder smooth muscle are drivers of afferent nerve activity during filling,” by Thomas J. Heppner et al., appears in the April issue of The Journal of General Physiology.

8-Mar-2016 1:05 PM EST
ROBO1 Helps Cells Put Up Stiff Resistance
The Rockefeller University Press

A protein called ROBO1 may delay the progression of breast cancer, according to a paper published in The Journal of Cell Biology. The study, “Loss of miR-203 regulates cell shape and matrix adhesion through ROBO1/Rac/FAK in response to stiffness” by Lily Thao-Nhi Le and colleagues, identifies a signaling pathway that may protect breast cells from the tumorigenic effects of stiff extracellular matrices.

   
8-Mar-2016 5:05 PM EST
Decrypting a Collagen’s Role in Schizophrenia
The Rockefeller University Press

A small peptide generated from a collagen protein may protect the brain from schizophrenia by promoting the formation of neuronal synapses, according to a paper published in The Journal of Cell Biology. The study, “Collagen-Derived Matricryptins Promote Inhibitory Nerve Terminal Formation in the Developing Neocortex” by Jianmin Su and colleagues, may lead to new approaches to treating the mental disorder.

Released: 18-Feb-2016 4:00 AM EST
New Insights into Epilepsy Drug Retigabine
The Rockefeller University Press

A recent study published ahead of print in the Journal of General Physiology has revealed new insights into Retigabine, a known pharmacological treatment for epilepsy.

3-Feb-2016 9:00 AM EST
Muscles on-a-Chip Provide Insight Into Cardiac Stem Cell Therapies
The Rockefeller University Press

Stem cell-derived heart muscle cells may fail to effectively replace damaged cardiac tissue because they don’t contract strongly enough, according to a study in The Journal of Cell Biology. The study, “Coupling Primary and Stem Cell-Derived Cardiomyocytes in an In Vitro Model of Cardiac Cell Therapy,” by Yvonne Aratyn-Schaus and Francesco Pasqualini and colleagues, may help explain why stem cell-based therapies have so far shown limited benefits for heart attack patients in clinical trials.

Released: 4-Feb-2016 12:00 AM EST
Potential New Approaches to Treating Eye Diseases
The Rockefeller University Press

Potential new approaches to treating eye diseases such as age-related macular degeneration (AMD) are described in a new study published in the February Journal of Experimental Medicine. Hongkang Xi, Menno van Lookeren Campagne, and colleagues discovered that a signaling protein, or cytokine, called IL-33, plays a key role in recruiting phagocytes to damaged retina and induces retinal degeneration. Blocking the IL-33 receptor inhibits this process and prevents injury-induced retinal degeneration.

1-Dec-2015 9:30 PM EST
A Supplement for Myelin Regeneration
The Rockefeller University Press

The vitamin D receptor (VDR) promotes the differentiation of oligodendrocyte progenitor cells (OPCs) and boosts myelin sheath regeneration, according to a study in The Journal of Cell Biology. The research suggests potential new ways to treat multiple sclerosis patients.

26-Aug-2015 1:05 PM EDT
Inducing Metabolic Catastrophe in Cancer Cells
The Rockefeller University Press

Researchers at Harvard Medical School describe a way to force cancer cells to destroy a key metabolic enzyme they need to survive.

6-Aug-2015 2:05 PM EDT
miR-7 Suppresses Stomach Cancer
The Rockefeller University Press

Researchers reveal that the microRNA miR-7 suppresses stomach cancer by inhibiting a key signaling pathway, and that this protective mechanism is compromised by the cancer-causing bacterium H. pylori. Finding drugs capable of inducing miR-7 could therefore prove to be an effective treatment against the progression of gastric cancer.

Released: 3-Aug-2015 9:05 AM EDT
Jodi Nunnari Named Editor-in-Chief of The Journal of Cell Biology
The Rockefeller University Press

Jodi Nunnari becomes the first woman to serve as editor-in-chief of The Journal of Cell Biology. A professor and chair of the Department of Molecular & Cellular Biology at the University of California, Davis, Nunnari succeeds the late Alan Hall, who passed away unexpectedly in May.

22-Jul-2015 11:05 AM EDT
Malaria’s Key to the Liver Uncovered
The Rockefeller University Press

Scientists uncover a port of liver entry for malaria parasites, and if these results hold up in humans, drugs that target this entry protein might help prevent the spread of disease.

22-Jul-2015 11:05 AM EDT
Lingering Lymphocytes Lash Out Against Leishmania
The Rockefeller University Press

Immune cells that hang around after parasitic skin infection help ward off secondary attack. These skin squatters may prove to be the key to successful anti-parasite vaccines.

14-Jul-2015 1:05 PM EDT
Stopping Malaria in Its Tracks
The Rockefeller University Press

A new drug acts as a roadblock for malaria, curing mice of established infection, according to researchers. Treatment was not associated with obvious side effects, suggesting that the drug may also be safe and effective in humans.

7-Jul-2015 1:05 PM EDT
Immune Cell Journey Has Bloody Consequences
The Rockefeller University Press

Immune cells that creep across blood vessels trigger potentially fatal bleeding in platelet-deficient mice, according to a new report. If the same is true in humans, blocking the passage of these cells could prevent dangerous complications in patients undergoing transplants or chemotherapy.

24-Jun-2015 11:45 AM EDT
Schwann Cells “Dine in” to Clear Myelin From Injured Nerves
The Rockefeller University Press

Researchers reveal how cells in the peripheral nervous system degrade myelin after nerve injury, a process that fails to occur in the central nervous system. The results could provide new targets for manipulating demyelination in injury and disease.

24-Jun-2015 10:05 AM EDT
A Microtubule “Roadway” in the Retina Helps Provide Energy for Vision
The Rockefeller University Press

Researchers have discovered a thick band of microtubules in certain neurons in the retina that they believe acts as a transport road for mitochondria that help provide energy required for visual processing.

Released: 2-Jun-2015 1:05 PM EDT
The Rockefeller University Press Welcomes Susan King as Executive Director
The Rockefeller University Press

The Rockefeller University Press (RUP) is pleased to announce that Susan King has joined the Press as Executive Director. King will oversee the editorial and business operations for RUP, publisher of The Journal of Experimental Medicine, The Journal of General Physiology, and The Journal of Cell Biology.

30-Apr-2015 1:05 PM EDT
Malarial Parasites Dodge the Kill
The Rockefeller University Press

Scientists have uncovered a potential mode of parasite drug resistance in malaria infection, opening new opportunities for the design of anti-malarial drugs.

30-Apr-2015 3:05 PM EDT
Study Reveals How a Rab Protein Controls HIV-1 Replication
The Rockefeller University Press

Researchers reveal how a Rab protein that controls intracellular trafficking supports HIV-1 assembly by promoting high levels of an important membrane lipid.

22-Apr-2015 9:05 AM EDT
Controlling Arterial Tone and Blood Flow in the Brain
The Rockefeller University Press

Researchers have performed the first human-based study to identify calcium channels in cerebral arteries and determine the distinct role each channel plays in helping control blood flow to the brain.

22-Apr-2015 9:05 AM EDT
Study Reveals How FOXO1 Slows Diabetic Wound Healing
The Rockefeller University Press

A protein that normally fosters tissue repair instead acts to inhibit healing when sugar levels are high. The role reversal helps explain why wounds heal slowly in people with diabetes.

2-Apr-2015 1:05 PM EDT
Researchers Define Role of Tmem231 in Maintaining Ciliary Function
The Rockefeller University Press

Researchers reveal how a protein linked to Meckel syndrome and other human diseases regulates the membrane composition of cilia, finger-like projections on the surface of cells that communicate signals.

19-Mar-2015 2:05 PM EDT
A Surprising Source of Serotonin Could Affect Antidepressant Activity
The Rockefeller University Press

Researchers have discovered an unconventional way that serotonin is released from neurons that could play an important role in the mechanism through which antidepressant drugs work.

   
25-Mar-2015 10:05 AM EDT
New Molecular Clues About Mysterious Brain Blood Vessel Disorder
The Rockefeller University Press

Yale researchers have uncovered new details about the relationship between two proteins associated with the formation of cerebral cavernous malformations, a little understood neurovascular disorder.

   
19-Mar-2015 10:05 AM EDT
Stress Granules Ease the Way for Cancer Metastasis
The Rockefeller University Press

Tumors that produce more stress granules are more likely to metastasize, according to researchers in Canada. The results suggest that drugs to inhibit the formation of these structures might rein in cancer metastasis.

11-Mar-2015 12:05 PM EDT
How NORE1A Acts as a Barrier to Tumor Growth
The Rockefeller University Press

Researchers reveal how cells protect themselves from a protein that is a key driver of cancer.

26-Feb-2015 12:05 PM EST
Promising New Strategy to Halt Pancreatic Cancer Metastasis
The Rockefeller University Press

Researchers have identified a novel treatment that could halt pancreatic cancer and prolong patient survival.

26-Feb-2015 12:05 PM EST
One Step Closer to Defeating Alzheimer's Disease
The Rockefeller University Press

Researchers show that toning down the activity of the receptor TREM2 may help put a stop to neurodegeneration in Alzheimer's disease.

26-Feb-2015 2:05 PM EST
Desmoplakin’s Tail Gets the Message
The Rockefeller University Press

Cells control the adhesion protein desmoplakin by modifying the tail end of the protein, and this process goes awry in some patients with arrhythmogenic cardiomyopathy, according to a new study.

26-Feb-2015 2:05 PM EST
Sall4 Is Required for DNA Repair in Stem Cells
The Rockefeller University Press

A protein that helps embryonic stem cells retain their identity also promotes DNA repair. The findings raise the possibility that the protein, Sall4, performs a similar role in cancer cells, helping them survive chemotherapy.

12-Feb-2015 10:00 AM EST
Study Reveals Possible Treatment for Diseases Caused by Mitofusin 2 Deficiency
The Rockefeller University Press

Researchers have discovered a novel role for Mitofusin 2, and the findings may point to a new treatment for patients with diseases caused by loss of the mitochondrial protein.

20-Jan-2015 10:00 AM EST
Learning From Scorpions to Control Impulses
The Rockefeller University Press

Scorpions can teach us a lot about the benefits of prolonging nerve impulses, and we might now be better students. The results of a new study could pave the way for easier identification of drugs that function similarly to scorpion venom, but with happier results for the recipient.

   
20-Jan-2015 10:00 AM EST
Leaky Channels Could Contribute to Unusual Heart Arrhythmias
The Rockefeller University Press

Leaks are not just problems for plumbers and politicians; researchers reveal how leaky transmembrane channels could cause disruptions in normal heart function. The study suggests that ion leaks in mutant sodium channels might contribute to an unusual set of cardiac arrhythmias.

21-Jan-2015 1:00 PM EST
Cells Take Sole Responsibility for Merkel Cell Maintenance
The Rockefeller University Press

Researchers have identified a population of “progenitor” cells in the skin that are solely responsible for the generation and maintenance of touch-sensing Merkel cells.

22-Jan-2015 12:00 PM EST
Study Reveals How Listeria Breaches the Placenta
The Rockefeller University Press

A gut bacterium called Listeria, which is often found in soft cheese, is known to present a risk to pregnant women. Researchers now show how Listeria uses distinct tactics to breach the intestine and the placenta, using a protein called PI3-kinase.

13-Jan-2015 1:00 PM EST
M6P Deficiency Leaves B Cells Out of Sorts
The Rockefeller University Press

A group of white blood cells known as B cells, which play a key role in the human immune response, need a protein-targeting signal called M6P in order to proliferate, differentiate, and present immune cell–activating antigens.

3-Dec-2014 12:00 PM EST
Macrophages Chase Neutrophils Away From Wounds to Resolve Inflammation
The Rockefeller University Press

Macrophages are best known for their Pac Man–like ability to gobble up cellular debris and pathogens in order to thwart infection. A new study describes how these immune cells also help resolve inflammation by inducing white blood cells called neutrophils to leave wounded tissue.

13-Nov-2014 10:00 AM EST
Infection-Fighting B Cells Go with the Flow
The Rockefeller University Press

Newly formed B cells take the easy way out when it comes to exiting the bone marrow, according to researchers at Yale University School of Medicine.

Released: 13-Nov-2014 3:00 PM EST
Study Offers New Clue Into How Anesthesia Works
The Rockefeller University Press

The activity of ion channel proteins that are important for cell-to-cell communication is markedly reduced during anesthesia, according to researchers from Weill Cornell Medical College.

6-Nov-2014 3:00 PM EST
How Brown Fat Fuels Up to Combat Type 2 Diabetes and Obesity
The Rockefeller University Press

A newly identified signaling pathway that stimulates glucose uptake in brown fat cells might be useful for treating type 2 diabetes and obesity.

23-Oct-2014 3:25 PM EDT
Obesity a Liability in Cancer Immunotherapy
The Rockefeller University Press

Packing on the pounds may lead to dangerous inflammation in response to anti-cancer treatment. A UC Davis study shows that overweight mice develop lethal inflammation in response to certain anti-cancer therapies, suggesting a possible link between body weight and adverse side effects.

30-Oct-2014 4:00 PM EDT
On the Throne with the Flu
The Rockefeller University Press

Flu infection has long-ranging effects beyond the lung that can wreak havoc in the gut and cause gastrointestinal symptoms, according to researchers in China. The study suggests ways to relieve these symptoms without interfering with the body’s ability to fight the flu virus in the lung.

22-Oct-2014 10:00 AM EDT
How Staph Infections Elude the Immune System
The Rockefeller University Press

By tricking the immune system into generating antibodies specific for only one bacterial protein, Staphylococcus aureus dodges the production of antibodies that might otherwise protect against infection. Vaccine approaches must be designed to side-step this bacterial subterfuge.

Released: 22-Oct-2014 11:10 AM EDT
The Rockefeller University Press Offers Free Access to Books
The Rockefeller University Press

The Rockefeller University Press has expanded access to its book collection, with nearly 50 titles available for free download in multiple e-book formats at books.rupress.org. The collection dates back to 1959 and includes works by Nobel and Pulitzer Prize–winning authors.

17-Oct-2014 10:00 AM EDT
Over-Organizing Repair Cells Set the Stage for Fibrosis
The Rockefeller University Press

The excessive activity of repair cells in the early stages of tissue recovery sets the stage for fibrosis by priming the activation of an important growth factor, according to a study in The Journal of Cell Biology.

Released: 13-Oct-2014 1:00 PM EDT
Out-of-Step Cells Spur Muscle Fibrosis in Duchenne Muscular Dystrophy Patients
The Rockefeller University Press

Like a marching band falling out of step, muscle cells fail to perform in unison in patients with Duchenne muscular dystrophy. Researchers reveal how this breakdown leads to the proliferation of stiff fibrotic tissue within muscles.


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