A new study led by scientists at The Scripps Research Institute (TSRI) sheds light on how the brain stores memories. The research, published recently in the journal eLife, is the first to demonstrate that the same brain region can both motivate a learned behavior and suppress that same behavior.
A new study led by scientists from the Florida campus of The Scripps Research Institute (TSRI) sheds light on a signaling circuit in cells that drives therapy resistance in prostate cancer. The researchers found that targeting the components of this circuit suppresses advanced prostate cancer development.
Breast cancer researchers from the Florida campus of The Scripps Research Institute (TSRI) have developed a novel approach for identifying how chemicals in the environment—called environmental estrogens—can produce infertility, abnormal reproductive development, including “precocious puberty,” and promote breast cancer.
The researchers said this study might help shed light on sudden infant death syndrome (SIDS) in human babies, which is thought to be associated with dysfunctional airway sensory neurons.
A new study led by scientists at The Scripps Research Institute (TSRI) is the first to show exactly how the drug Arbidol stops influenza infections. The research reveals that Arbidol stops the virus from entering host cells by binding within a recessed pocket on the virus.
In a new study, scientists from the Florida campus of The Scripps Research Institute (TSRI) have shown how two genes “balance” each other to maintain normal cell function. A disruption in one of the genes, called spns1, can induce degradation and premature “senescence”—or aging—while the other gene, called atp6v0ca, can jump in to suppress that degradation.
Scientists from the Florida campus of The Scripps Research Institute (TSRI) have developed an efficient process to rapidly discover new “enediyne natural products” from soil microbes that could be further developed into extremely potent anticancer drugs.
Ron Davis, chair of the Department of Neuroscience on the Florida campus of The Scripps Research Institute (TSRI) has been awarded a $5 million Outstanding Investigator Grant, one of the first of its kind, by the National Institute of Neurological Disorders and Stroke (NINDS) of the National Institutes of Health (NIH).
Diet composition around the time of pregnancy may influence whether offspring become obese, according to a new study using animal models at The Scripps Research Institute (TSRI).
Scientists on the Florida campus of The Scripps Research Institute (TSRI) have developed broad methods to design precision medicines against currently incurable diseases caused by RNA.
New research led by scientists at The Scripps Research Institute (TSRI) reveals that a human enzyme has changed little from its days as a bacterial enzyme.
Scientists from the Florida campus of The Scripps Research Institute (TSRI) have made an important discovery toward the development of drugs to treat age-related memory loss in diseases like Alzheimer’s.
A common class of drugs for vision loss may actually add to the problem in some patients, according to new research co-led by scientists at The Scripps Research Institute (TSRI).
In a new study, scientists from the Florida campus of The Scripps Research Institute (TSRI) have identified a possible drug candidate that suppresses pain and itch in animal models.
Scientists at The Scripps Research Institute (TSRI) have developed a vaccine that blocks the pain-numbing effects of the opioid drugs oxycodone (oxy) and hydrocodone (hydro) in animal models.
Scientists from the Florida campus of The Scripps Research Institute (TSRI), Florida Atlantic University and Bowling Green State University may have finally found a reason for the 'food coma' phenomenon.
Two scientists at The Scripps Research Institute (TSRI) have been elected fellows of the American Association for the Advancement of Science (AAAS).
A new study by scientists from the Florida campus of The Scripps Research Institute (TSRI) offers a novel structure-based drug design strategy aimed at altering the basic landscape of this type of breast cancer treatment.
In new findings that could have an impact the development of therapies for a number of currently untreatable brain disorders such as Parkinson’s and Huntington’s diseases, scientists from the Florida campus of The Scripps Research Institute (TSRI) have found for the first time that a specific signaling circuit in the brain is deeply involved in motor activity.
A new study led by scientists at The Scripps Research Institute (TSRI) describes an unexpected role for proteins involved with our daily “circadian” clocks in influencing cancer growth.
Scientists from the Florida campus of The Scripps Research Institute (TSRI) have discovered that mutations in PTEN affect the assembly of connections between two brain areas important for the processing of social cues: the prefrontal cortex, an area of the brain associated with complex cognitive processes such as moderating social behavior, and the amygdala, which plays a role in emotional processing.
A new study led by scientists at The Scripps Research Institute (TSRI) reveals that a protein first discovered at TSRI in 2010 is directly responsible for sensing touch.
TSRI Researchers Believe Cell Population May Provide a New Cancer Drug Target
Scientists from the Florida campus of The Scripps Research Institute (TSRI) have now for the first time identified a sub-region in the brain that works to form a particular kind of memory: fear-associated with a specific environmental cue or “contextual fear memory.”
A new study co-led by scientists at The Scripps Research Institute (TSRI) suggests that Ebola virus gained a genetic mutation during the 2013–16 epidemic that appears to have helped it better target human cells.
Scientists at The Scripps Research Institute (TSRI) have developed a broadly useful method to unmask new functional features of human proteins.
In a remarkable “two for one” discovery, scientists from the Florida campus of The Scripps Research Institute (TSRI) have illuminated a key molecular player in the addictive effects of morphine in animal models.
Researchers have been trying for decades to develop a vaccine against the globally endemic hepatitis C virus (HCV). Now scientists at The Scripps Research Institute (TSRI) have discovered one reason why success has so far been elusive.
In a discovery that advances the understanding of how marijuana works in the human body, an international group of scientists, including those from the Florida campus of The Scripps Research Institute (TSRI), have for the first time created a three-dimensional atomic-level image of the molecular structure activated by tetrahydrocannabinol (THC), the active chemical in marijuana.
The Scripps Research Institute (TSRI) and the California Institute for Biomedical Research (Calibr) – two leading non-profit research organizations – today announced the signing of a strategic affiliation that combines the two organizations into a new biomedical research entity with the tools and know-how to rapidly translate its scientific discoveries into life-saving medicines for the public benefit.
In a study that could one day help eliminate the tragic birth defects caused by Zika virus, scientists from the Florida campus of The Scripps Research Institute (TSRI) have elucidated how the virus attacks the brains of newborns, information that could accelerate the development of treatments.
Bringing the world one step closer to when destructive addiction-fueling memories can be erased with a single treatment, scientists from the Florida campus of The Scripps Research Institute have received a National Institutes of Health grant through the Blueprint Neurotherapeutics Network and the National Institute of Drug Abuse.
In a series of studies led by Assistant Professor Anutosh Chakraborty of The Scripps Research Institute Florida campus, scientists have identified a key protein that promotes fat accumulation in animal models by slowing the breakdown and expenditure of fat and encouraging weight gain.
A study led by scientists at The Scripps Research Institute and the Scripps Translational Science Institute suggests “molecular autopsies” may help detect gene mutations underlying a sudden death. The research, while early, could help doctors alert living family members to hidden health conditions.
The National Institutes of Health has expanded a five-year funding award to The Scripps Research Institute from $120 million to $207 million, marking a significant increase in scope from the initial award and providing additional details about the network of partners in the TSRI-led consortium.
Scientists at The Scripps Research Institute have received a grant of nearly $1.9 million from the National Institute of General Medical Sciences and a grant of $640,000 from the National Science Foundation for two new projects that take advantage of "click chemistry."
Peter Schultz, president of The Scripps Research Institute, has been awarded the international Heinrich Wieland Prize, one of Germany’s most prestigious scientific prizes.
A new study led by scientists at The Scripps Research Institute (TSRI) offers a twist on a popular theory for how life on Earth began about four billion years ago.
Chemist Jin-Quan Yu of The Scripps Research Institute (TSRI) has won a 2016 MacArthur Fellowship, sometimes called a “genius grant.”
A study by scientists at The Scripps Research Institute has helped to de-mystify the molecular workings of the multiple sclerosis drug Tecfidera®. The drug is the most widely prescribed pill-based therapy for MS, but its biological mechanism remains mysterious.
Scientists at The Scripps Research Institute have discovered a potential new weapon against Clostridium difficile, a bacterium that causes hundreds of thousands of severe intestinal infections in the U.S. every year and is frequently fatal.
Scientists at The Scripps Research Institute (TSRI) have brought physics and biology together to further understand how cells’ crowded surfaces induce complex protein behavior.
A new study from scientists at The Scripps Research Institute shows that “holes” in HIV’s defensive sugar shield could be important in designing an HIV vaccine.
A series of new studies led by scientists at The Scripps Research Institute and the International AIDS Vaccine Initiative describe a potential vaccination strategy to jump-start the selection and evolution of broadly effective antibodies to prevent HIV infection.
There may be a way to switch off the urge for compulsive drinking, according to a new study in animal models led by scientists at The Scripps Research Institute.
Chemists at The Scripps Research Institute have invented a new technique for constructing one-handed or “chiral” drug molecules. The new method is already being adopted by pharmaceutical researchers.
In a new study, scientists from the Florida campus of The Scripps Research Institute offer new insights how calcium in mitochondria—the powerhouse of all cells—can impact the development of the brain and adult cognition.
A well-known family of natural compounds, called “terpenoids,” have a curious evolutionary origin. In particular, one question relevant to future drug discovery has puzzled scientists: exactly how does Nature make these molecules?
An international team led by scientists at The Scripps Research Institute (TSRI) has found strong evidence supporting a new strategy against drug addiction.
RSS
Medicine keyboard_arrow_right
Sciencekeyboard_arrow_right
Life keyboard_arrow_right
Business keyboard_arrow_right
Journal News keyboard_arrow_right
By Location keyboard_arrow_right
Meetings, Grants, and Events keyboard_arrow_right