New research by University of Wisconsin–Madison scientists reveals how a cellular filament helps neural stem cells clear damaged and clumped proteins, an important step in eventually producing new neurons.
Parkinson’s disease researchers have used gene-editing tools to introduce the disorder’s most common genetic mutation into marmoset monkey stem cells and to successfully tamp down cellular chemistry that often goes awry in Parkinson’s patients.
New research on sand dunes in China describes how even neighboring dunes can long remain in different and seemingly conflicting states — confounding the assessment of stabilization efforts and masking the effects of climate change.
A small amount of electricity delivered at a specific frequency to a particular point in the brain will snap a monkey out of even deep anesthesia, pointing to a circuit of brain activity key to consciousness and suggesting potential treatments for debilitating brain disorders.
Stacking ultrathin complex oxide single-crystal layers allows researchers to create new structures with hybrid properties and multiple functions. Now, using a new platform developed by engineers at the University of Wisconsin–Madison and the Massachusetts Institute of Technology, researchers will be able to make these stacked-crystal materials in virtually unlimited combinations.
University of Wisconsin–Madison researchers have developed nanoparticles that, in the lab, can activate immune responses to cancer cells. If they are shown to work as well in the body as they do in the lab, the nanoparticles might provide an effective and more affordable way to fight cancer.
Drawing inspiration from nature, University of Wisconsin–Madison chemists have discovered an efficient way to wrangle long, snaking molecules to form large rings — rings that form the backbone of many pharmaceuticals but are difficult to produce in the lab.
Measuring changes in the speed of electrical signals along nerves connecting the eyes to the brain may accurately reflect recovery from myelin loss in multiple sclerosis (MS), according to researchers at the University of Wisconsin–Madison, and could be used to evaluate new treatments for the disease.
Research published this week by University of Wisconsin–Madison scientists shows how bacteria can degrade solid bedrock, jump-starting a long process of alteration that creates the mineral portion of soil.
University of Wisconsin-Madison researchers examined the effects of baloxavir treatment on influenza virus samples collected from patients before and after treatment.
New research shows that when stocks of fish get so low that it becomes a greater challenge to catch them, many anglers step up to the challenge and continue catching fish. This poses a threat to the long-term health of sportfish populations in Wisconsin and in inland recreational fisheries around the world.
University of Wisconsin–Madison researchers have cultivated lifelike chemical reactions while pioneering a new strategy for studying the origin of life.
According to a new study published today [Nov. 4, 2019] in the Proceedings of the National Academy of Sciences, 40 years of reduced mercury use, emissions, and loading in the Great Lakes region have largely not produced equivalent declines in the amount of mercury accumulating in large game fish.
A new study of 3,000 people in Wisconsin aged 21 and older with Down syndrome, published today [Monday, Oct. 28, 2019] in JAMA Neurology by researchers at the University of Wisconsin–Madison, shows that by age 55, three in five will be diagnosed with Alzheimer’s disease or a similar neurodegenerative condition. Meanwhile, people without Down syndrome are rarely diagnosed with dementia before age 65.
A research team reports that PBO interferes with the critical signaling pathway dubbed by scientists as sonic hedgehog, resulting in stunted forebrain development and signature facial abnormalities.
In the deepest look yet at the diversity of these yeasts, scientists from the University of Wisconsin–Madison reveal the dizzying complexity found in bottles of beer, wine and cider. By sequencing the genomes of more than 100 hybrid yeasts, the researchers discovered seven distinct combinations of yeast species, many of them tied to unique fermented beverages.
Researchers have discovered a previously unknown virus infecting nearly a third of America’s bald eagle population. Scientists at the University of Wisconsin–Madison, USGS and the Wisconsin DNR found the virus while searching for the cause of Wisconsin River Eagle Syndrome, an enigmatic disease endemic to bald eagles near the Lower Wisconsin River. The newly identified bald eagle hepacivirus, or BeHV, may contribute to the fatal disease, which causes eagles to stumble and have seizures.
Millions of people with severe burns or diabetic skin ulcers could benefit from an experimental enhancement to a next-generation covering that is already healing difficult wounds.
By connecting small, restored patches of savanna to one another via habitat corridors at an experimental landscape within the Savannah River Site in South Carolina, a nearly 20-year-long study has shown an annual increase in the number of plant species within fragments over time, and a drop in the number of species disappearing from them entirely.
Reversing baldness could someday be as easy as wearing a hat, thanks to a noninvasive, low-cost hair-growth-stimulating technology developed by engineers at the University of Wisconsin–Madison.
Researchers at the University of Wisconsin–Madison have packed a gene-editing payload into a tiny customizable, synthetic nanocapsule. They described the delivery system and its cargo today (Sept. 9, 2019) in the journal Nature Nanotechnology.
Researchers from the University of Wisconsin–Madison and Marshfield Clinic have found that there may be a much broader health risk to carriers of the FMR1 premutation, with potentially dozens of clinical conditions that can be ascribed directly to carrying it. The researchers employed machine learning to mine decades of electronic health records of nearly 20,000 individuals.
Edwin Chapman of the Howard Hughes Medical Institute and the University of Wisconsin–Madison reports that halting production of synaptotagmin 17 (syt-17) blocks growth of axons. Equally significant, when cells made more syt-17, axon growth accelerated. A wide range of neurological conditions could benefit from the growth of axons, including spinal cord injuries and some neurodegenerative diseases.
For nearly 100 years, scientists thought they understood everything there was to know about how metals bend. They were wrong. Researchers at the University of Wisconsin–Madison have demonstrated that the rules of metal-bending aren’t so hard and fast after all. Their surprising discovery not only upends previous notions about how metals deform, but could help guide the creation of stronger, more durable materials.
Every several hundred thousand years or so, Earth's magnetic field dramatically shifts and reverses its polarity. New work from University of Wisconsin–Madison geologist Brad Singer and his colleagues finds that the most recent field reversal took several times longer than previously thought, and the results further call into question controversial findings that some reversals could occur within a human lifetime.
Scientists from the University of Wisconsin-Madison and the Universidad de Zaragoza in Spain, drawing on the lessons of classical optics, have shown that it is possible to image complex hidden scenes using a projected “virtual camera” to see around barriers.
A new study by University of Wisconsin–Madison physicists mimicked solar winds in the lab, confirming how they develop and providing an Earth-bound model for the future study of solar physics.
IceCube, the Antarctic neutrino detector that in July of 2018 helped unravel one of the oldest riddles in physics and astronomy — the origin of high-energy neutrinos and cosmic rays — is getting an upgrade. This month, the National Science Foundation (NSF) approved $23 million in funding to expand the detector and its scientific capabilities. Seven new strings of optical modules will be added to the 86 existing strings already embedded in the ice beneath the geographic South Pole.
A new study led by University of Wisconsin–Madison researchers Caitlin Pepperell and Bruce Klein has identified a specific genetic vulnerability among Hmong people that renders them more susceptible to the disease-causing fungus.
University of Wisconsin-Madison engineers have devised a method to create pieces of “smart” glass that can recognize images without requiring any sensors or circuits or power sources.
Irrigation dropped maximum temperatures by one to three degrees Fahrenheit on average while increasing minimum temperatures up to four degrees compared to unirrigated farms or forests, new research shows.
The world’s wood products — all the paper, lumber, furniture and more — offset just 1 percent of annual global carbon emissions by locking away carbon in woody forms, according to new University of Wisconsin–Madison research.
U.S. hospitals wait over a year on average to begin prescribing newly developed antibiotics, a delay that might threaten the supply or discourage future development of needed drugs, according to a University of Wisconsin–Madison study.
New research out of the University of Wisconsin–Madison Arboretum shows that temperatures of about 100 degrees Fahrenheit kill the cocoons of invasive jumping worms. That’s good news for ecologists and horticulturalists who are working to slow or stop the spread of the worms, which can damage the soils they invade.
A new, more accessible and much cheaper approach to surveying the topology and strength of interstellar magnetic fields — which weave through space in our galaxy and beyond, representing one of the most potent forces in nature — has been developed by researchers at the University of Wisconsin–Madison.
A jawless parasitic fish could help lead the way to more effective treatments for multiple brain ailments, including cancer, trauma and stroke. A team of biomedical engineers and clinician-scientists at the University of Wisconsin–Madison and the University of Texas at Austin borrowed molecules from the immune system of the parasitic sea lamprey to deliver anti-cancer drugs directly to brain tumors.
A study published in the journal Stem Cells describes a new and unexpected way to accelerate the maturation of induced pluripotent stem cells into cardiac muscle cells.
A new study published in Cell Reports by a team of researchers at the University of Wisconsin–Madison’s Wisconsin Institute for Discovery and School of Medicine and Public Health could improve the efficiency of creating induced pluripont stem cells.
The University of Wisconsin–Madison’s Robert Fettiplace has been named a 2019 Passano Fellow for his research into the mechanics of hearing, his second prestigious international scientific prize in a year. Fettiplace, a professor of neuroscience at the UW School of Medicine and Public Health won the award for showing how cochlear hair cells sense the tiny mechanical vibrations that sound produces in the inner ear.
In new research, a team from the Great Lakes Bioenergy Research Center and the University of Wisconsin–Madison describe an efficient and economically feasible process for producing HMF, a versatile plant-derived chemical considered crucial for building a renewable economy.
A new technology developed by the University of Wisconsin–Madison’s Yoshihiro Kawaoka may make H3N2 vaccine development a bit easier. In Nature Microbiology today [April 29, 2019], Kawaoka and his team describe a new cell line that enables better growth of H3N2 for vaccine use. The virus is also far less likely to mutate during production using this cell line, improving the chances of a match between vaccine and circulating influenza viruses.
New research suggests that the microbial communities associated with chronic wounds common in diabetic patients affect whether those wounds heal or lead to amputations.
A novel strategy capable of extracting and driving hard-to-reach proteins into water solution where they can be effectively studied using mass spectrometry promises a trove of biological insights and, importantly, may help identify therapeutically relevant proteins and provide new disease diagnostic techniques.
The shade of a single tree can provide welcome relief from the hot summer sun. But when that single tree is part of a small forest, it creates a profound cooling effect. According to a study published today in the Proceedings of the National Academy of Sciences, trees play a big role in keeping our towns and cities cool.
A fungicide commonly used by the agricultural industry to protect grains, fruit and vegetables from mold damage seems to kill fungi by a previously uncharacterized mechanism that delivers a metabolic shock to cells, new research at the University of Wisconsin–Madison finds.
We all know that turning off lights and buying energy-efficient appliances affects our financial bottom line. Now, according to a new study by University of Wisconsin–Madison researchers, we know that saving energy also saves lives and even more money for consumers by alleviating the costs of adverse health effects attributed to air pollution.
A team led by University of Wisconsin–Madison cancer researchers Richard A. Anderson and Vincent Cryns reports the discovery of an unexpected regulator of the critical protein p53, opening the door to the development of drugs that could target it.
University of Wisconsin researchers developed a community they named THOR, three species of bacteria isolated from soybean roots and grown together. The complex community of microbes developed new behaviors together that couldn’t be predicted from the individual members alone — they grew tougher structures known as biofilms, changed how they moved across their environment, and controlled the release of a novel antibiotic.