The discovery of a major gear in the biological clock that tells the body when to sleep and metabolize food may lead to new drugs to treat sleep problems and metabolic disorders, including diabetes.
Faculty members Reuben Shaw and Lei Wang, have been promoted to the position of Associate Professor at the Salk Institute after a rigorous evaluation process by Salk senior faculty, Non-Resident Fellows, and scientific peers. The career milestone distinguishes these two investigators as leading authorities in their respective disciplines who have made original, innovative and notable contributions to biological research.
Worm model of back-up telomere repair strategy could speed identification of anti-cancer drugs.
The well-being of living cells requires specialized squads of proteins that maintain order. Degraders chew up worn-out proteins, recyclers wrap up damaged organelles, and-most importantly-DNA repair crews restitch anything that resembles a broken chromosome. If repair is impossible, the crew foreman calls in executioners to annihilate a cell. As unsavory as this last bunch sounds, failure to summon them is one aspect of what makes a cancer cell a cancer cell.
A single injection of cocaine or methamphetamine in mice caused their brains to put the brakes on neurons that generate sensations of pleasure, and these cellular changes lasted for at least a week, according to research by scientists at the Salk Institute for Biological Studies.
Renato Dulbecco, M.D., Nobel Prize winner and a global leader in cancer research passed away February 19 at his home in La Jolla. Born on February 22, 1914, he was just shy of his 98th birthday.
Drugs targeting an enzyme involved in inflammation might offer a new avenue for treating certain lung cancers, according to a new study by scientists at the Salk Institute for Biological Studies.
Researchers at the Salk Institute have discovered a startling feature of early brain development that helps to explain how complex neuron wiring patterns are programmed using just a handful of critical genes. The findings, published February 3 in Cell, may help scientists develop new therapies for neurological disorders, such as amyotrophic lateral sclerosis (ALS), and provide insight into certain cancers.
Reviving a theory first proposed in the late 1800s that the development of organs in the normal embryo and the development of cancers are related, scientists at the Salk Institute for Biological Studies have studied organ development in mice to unravel how breast cancers, and perhaps other cancers, develop in people. Their findings provide new ways to predict and personalize the diagnosis and treatment of cancer.
One of the big mysteries in biology is why cells age. Now scientists at the Salk Institute for Biological Studies report that they have discovered a weakness in a component of brain cells that may explain how the aging process occurs in the brain.
The Genetics Society of America (GSA) has honored Joanne Chory, Salk Institute professor and director of the Plant Molecular and Cellular Biology Laboratory and Howard H. and Maryam R. Newman Chair in Plant Biology, as the recipient of the prestigious 2012 Genetics Society of America Medal.
Salk Institute scientist Ronald Evans has been selected as the recipient of the prestigious 2012 Wolf Prize in Medicine, Israel's highest award for achievements benefiting mankind. According to the Wolf Prize jury, Evans was selected for his discovery of the gene super-family encoding nuclear receptors and elucidating the mechanism of action of this class of receptors.
Scientists at the Salk Institute for Biological Studies have identified a gene that tells cells to develop multiple cilia, tiny hair-like structures that move fluids through the lungs and brain. The finding may help scientists generate new therapies that use stem cells to replace damaged tissues in the lung and other organs.
Salk scientist made significant discoveries in brain health, heart failure, metabolism and hormones.
Pioneering vision study in mice will help revolutionize the study of brain function and mental disease.
Scientists have discovered a missing link between the body's biological clock and sugar metabolism system, a finding that may help avoid the serious side effects of drugs used for treating asthma, allergies and arthritis.
Salk scientists develop new drug that improves memory and prevents brain damage in mice.
Researchers at the Salk Institute for Biological Studies have developed a way to use patients' own cells to potentially cure sickle cell disease and many other disorders caused by mutations in a gene that helps produce blood hemoglobin.
An international team of scientists has created super-strong, high-endurance mice and worms by suppressing a natural muscle-growth inhibitor, suggesting treatments for age-related or genetics-related muscle degeneration are within reach.
One of the few reliable ways to extend an organism's lifespan, be it a fruit fly or a mouse, is to restrict calorie intake. Now, a new study in fruit flies is helping to explain why such minimal diets are linked to longevity and offering clues to the effects of aging on stem cell behavior.
A new class of anti-inflammatory drugs may one day serve as an alternative to steroid medications and possibly help avoid the serious side effects of steroids, based on research findings at the Salk Institute for Biological Studies.
The National Academy of Sciences announced today the appointment of Inder M. Verma as Editor-in-Chief of the Proceedings of the National Academy of Sciences (PNAS), the official journal of the Academy. He will formally assume the editorship on Nov. 1, and the transition to the new position will occur over several weeks.
A discovery by scientists at the Salk Institute for Biological Studies might explain why some premature infants fail to respond to existing treatments for a deadly respiratory distress syndrome (RDS) and offers clues for new ways to treat the breathing disorder.
The SCImago Institutions Rankings (SIR) World Report has identified the Salk Institute as one of the top five research organizations in the world, based on excellence and high quality of its scientific findings.
The National Institutes of Health has announced that the Salk Institute will receive $4.5 million to establish a Neuroscience Core Center, a new research center intended to accelerate brain research that lays the foundation for developing new ways to treat congenital brain defects and neurological diseases.
Ever wondered why you wake up in the morning ---- even when the alarm clock isn't making jarring noises? Wonder no more. Researchers at the Salk Institute for Biological Studies have identified a new component of the biological clock, a gene responsible for starting the clock from its restful state every morning.
Dr. Fred Gage, a professor in the Salk Institute Laboratory of Genetics and holder of the Vi and John Adler Chair for Research on Age-Related Neurodegenerative Diseases, has been named a 2011 recipient of the prestigious National Institutes of Health (NIH) Director's Transformative Research Projects (T-R01) program.
Researchers at the Salk Institute have discovered how a hormone turns on a series of molecular switches inside the pancreas that increases production of insulin.
-A strain of genetically enhanced bacteria developed by researchers at the Salk Institute for Biological Studies may pave the way for new synthetic drugs and new ways of manufacturing medicines and biofuels, according to a paper published September 18 in Nature Chemical Biology.
Axel Nimmerjahn, Ph.D., assistant professor in the Waitt Advanced Biophotonics Center and holder of the Richard Allan Barry Developmental Chair in Biophotonics has been awarded a highly selective grant from the Whitehall Foundation. He will receive $223,000.00 over three years to study the contribution of astrocytes to normal brain function.
A "hidden" code linked to the DNA of plants allows them to develop and pass down new biological traits far more rapidly than previously thought, according to the findings of a groundbreaking study by researchers at the Salk Institute for Biological Studies.
Oncologists have long sought a powerful "magic bullet" that can find tumors wherever they hide in the body so that they can be imaged and then destroyed. Until recently scientists accepted the notion that such an agent, an agonist, needed to enter and accumulate in the cancerous cells to act. An international research team has now shown in cancer patients that an investigational agent that sticks onto the surface of tumor cells without triggering internalization, an antagonist, may be safer and even more effective than agonists.
If you think today's political rhetoric is overheated, imagine what goes on inside a vertebrate embryo. There, two armies whose agendas are poles apart, engage in a battle with consequences much more dire than whether the economy will recover---- they are battling for whether you (or frogs or chickens) will have a forebrain.
Thomson Reuters Essential Science Indicators has seeded the Salk Institute as the number one research organization for plant biology in the world.
Salk Institute and Dana Farber Cancer Institute researchers contribute to production of largest-ever map of plant protein interactions.
Drug developers have long been looking for agents that will target a cell receptor that regulates stress in humans, but no small molecule drugs have successfully gone through clinical studies. Now, a team at the Salk Institute has demonstrated how a novel tool can be used to map the binding sites on this receptor, which they say could speed the design of effective therapies.
Researches near goal of using a patient's own cells to make stem cells that can replace lost or diseased tissue.
Ipsen and the Salk Institute for Biological Studies announced today that they are renewing the Ipsen Life Sciences Program at the Salk Institute. The mission of the partnership is to advance knowledge in the field of proliferative and degenerative diseases through fundamental and applied biology research.
Researchers at the Salk Institute have been able to genetically incorporate "unnatural" amino acids, such as those emitting green fluorescence, into neural stem cells, which then differentiate into brain neurons with the incandescent "tag" intact.
Scientists at the Salk Institute for Biological Studies have found clues to the functioning of an important damage response protein in cells. The protein, p53, can cause cells to stop dividing or even to commit suicide when they show signs of DNA damage, and it is responsible for much of the tissue destruction that follows exposure to ionizing radiation or DNA-damaging drugs such as the ones commonly used for cancer therapy. The new finding shows that a short segment on p53 is needed to fine-tune the protein’s activity in blood-forming stem cells and their progeny after they incur DNA damage.
A recent study from scientists at the Salk Institute for Biological Studies suggests that a strawberry a day (or more accurately, 37 of them) could keep not just one doctor away, but an entire fleet of them, including the neurologist, the endocrinologist, and maybe even the oncologist.
The Salk Institute for Biological Studies announced that Dr. Axel Nimmerjahn, Assistant Professor in the Waitt Advanced Biophotonics Center and holder of the Richard Allan Barry Developmental Chair, has been named a 2011 Rita Allen Scholar. Nimmerjahn is one of seven scientists out of 28 candidates to be selected this year and only the third Salk faculty member to receive this award.
Ecker, who was cited by TIME Magazine for having one of the most important scientific findings in 2009, brings record number of HHMI Salk appointments to nine.
Birds do it, bees do it, and for most things biological, even plants do it. But not necessarily like their animal counterparts. A study led by Salk Institute scientists shows that a plant receptor does one of the most fundamental cellular “its”—the delivery of a hormonal signal from outside the cell to the nucleus—in a radically different way than its animal cousins. Knowing that could aid creation of techniques to speed plant growth and enhance agricultural production.
The Salk Institute for Biological Studies is proud to announce that the Salk Educational Outreach program was honored May 25, 2011 by the San Diego Unified School District as a 20-year Partner in Education at a special End-of-Year Partner/Volunteer Awards Ceremony honoring 10, 20, and 25-year partners, Volunteers of the Year, and Partners of the Year.
Today, the Salk Institute for Biological Studies announced the visionary gift of Irwin and Joan Jacobs in the dedication of two endowed chairs to pay permanent tribute to Drs. Dulbecco and Guillemin, two of Salk's Nobel Prize winners as well as former Presidents, for their incredible achievements in science and research, the leadership they have provided over the years, and for the legions of scientists they have mentored and inspired.
Salk leaders, Chory and non-resident fellow Carla J. Shatz, elected to join prestigious group of the world's most eminent scientists; Newton, Darwin, Einstein, Crick, Watson, Hawking and many others.
A multi-institutional team headed by Ursula Bellugi, professor and director of the Laboratory for Cognitive Neuroscience at the Salk Institute for Biological Studies, has been awarded a $5.5 million Program Project Grant by the National Institute of Child Health and Human Development (NICHD) to link social behavior to its underlying neurobiological and molecular genetic basis using Williams syndrome as a model.
In principle, genetic engineering is simple, but in practice, replacing a faulty gene with a healthy copy is anything but. Using mutated versions of the lamin A gene as an example to demonstrate the versatility of their virus-based approach, researchers at the Salk Institute for Biological Studies successfully edited a diseased gene in patient-specific induced pluripotent stem cells as well as adult stem cells.
The seeds sprouting in your spring garden may still be struggling to reach the sun. If so, they are consuming a finite energy pack contained within each seed. Once those resources are depleted, the plant cell nucleus must be ready to switch on a “green” photosynthetic program. Researchers at the Salk Institute for Biological Studies recently showed a new way that those signals are relayed.
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