A recent Paper of the Week published in the Journal of Biological Chemistry examines how cells recovering from damage induced by a high-fat diet can be treated with a drug for type 2 diabetes called metformin to reverse the effects of metabolic memory.
Depression is a mental illness that affects how a person feels, thinks and handles daily activities. Antidepressants are prescribed to alleviate the symptoms of depression and help the brain process and use certain chemicals that regulate mood or stress. Unfortunately, existing medications usually require two to four weeks of use before patients respond.
Here is a list of the ASBMB's annual award winners.
In the late 1800s, William B. Coley created a concoction out of bacteria and injected it into cancer patients. The first patient treated with what became known as “Coley’s Toxins” — a 21-year-old man with an inoperable tumor — was cured of his cancer. Though that might not have been the very first foray into immunotherapy as cancer treatment, it certainly was one of the earliest. Coley spent decades studying how bacterial infections affected cancers, earning him the moniker of the “father of immunotherapy.” Since then, the field has come a long way.
Seven milliliters of a king cobra’s venom can kill 20 people. But what exactly is in the snake’s venom? Researchers have pursued that question for decades.
One of the many insults of adolescence is pimple-speckled skin. Sebum, an oily skin secretion, plays a major role in causing zits. But “the knowledge of what exactly in sebum is responsible for the occurrence of acne is rather limited,” says Emanuela Camera at the San Gallicano Dermatologic Institute in Italy.
The American Society for Biochemistry and Molecular Biology will hold its annual meeting April 2 – 6 at the San Diego Convention Center. This tipsheet describes featured presentations by undergraduate students and faculty members of primarily undergraduate institutions.
The American Society for Biochemistry and Molecular Biology will hold its annual meeting April 2 – 6 at the San Diego Convention Center. Here is a list of the ASBMB’s annual award and plenary lecturers (in order of lecture times).
The American Society for Biochemistry and Molecular Biology will hold its annual meeting April 2 – 6 at the San Diego Convention Center. Below are the scientific symposia highlights.
The American Society for Biochemistry and Molecular Biology announced Tuesday that Lila M. Gierasch, a distinguished faculty member at the University of Massachusetts Amherst, will be the next editor in chief of the Journal of Biological Chemistry, the nonprofit’s peer-reviewed journal.
The American Society for Biochemistry and Molecular Biology will host a summit Feb. 4 – 5 to determine the actions necessary to solve problems confronting the American biomedical research enterprise. Training periods and trainee populations have increased over the past decade despite stagnant federal funding, resulting in a research workforce that is expanding beyond the capacity of the available funding to support it.
Despite the prevalence of thyroid disease and its sometimes serious effects, researchers have struggled to answer a pretty basic question about the hormone-producing gland: What turns it on? A study published in this week’s issue of the Journal of Biological Chemistry provides an answer, and that answer was found within the gland itself.
The American Society for Biochemistry and Molecular Biology this week named 15 scientists the winners of its annual awards. Winners were nominated by colleagues and other leaders in their fields for making significant contributions to biochemistry and molecular biology. The recipients will give talks about their research and teaching at the society's 2016 annual meeting, which will be held in conjunction with the Experimental Biology conference April 2-6 in San Diego.
Five students from across the United States earned Distinguished Undergraduate Scholarships from the American Society for Biochemistry and Molecular Biology for their academic accomplishments in the face of adversity and commitment to increasing educational access for underrepresented students.
The National Science Foundation awarded the American Society for Biochemistry and Molecular Biology a grant of half a million dollars to support a comprehensive mentoring program for postdoctoral fellows and early-career faculty members.
In an article published today in the Proceedings of the National Academy of Sciences, members of the American Society for Biochemistry and Molecular Biology describe eight steps that should be improve the sustainability of the scientific enterprise.
The Journal of Biological Chemistry today welcomed F. Peter Guengerich of Vanderbilt University as the journal’s interim editor-in-chief.
Young scientists from colleges and universities across the United States will arrive on Capitol Hill on Thursday to meet with senators and representatives about the value of biomedical research. Now in its seventh year, the American Society for Biochemistry and Molecular Biology’s (ASBMB) Hill Day will give 20 young researchers the chance to participate in up to 90 meetings with lawmakers and congressional staff about the work they are doing.
Most of us probably know at least one woman, and maybe quite a few more, with endometriosis. Despite the disease’s prevalence, there is no consensus on the cause of it, the existing treatment options leave a lot to be desired, and there are too few ways for women to, at the very least, effectively numb the pain that the disease provokes. A team of researchers hunting biomarkers to be used in diagnostics and perhaps a personalized approach to treating endometriosis will present its findings Tuesday at the Experimental Biology 2013 conference in Boston.
A potential new way to fight obesity-related illness has been uncovered, thanks to a serendipitous finding by investigators at the Case Western Reserve University School of Medicine. They’ll present their work Tuesday at the Experimental Biology conference in Boston.
Since 1997, a shrubby perennial found only in East Texas has been on a waiting list to be officially declared by the U.S. Fish and Wildlife Service as threatened. A ruling on the fate of the Neches River rose-mallow is expected by 2016, but the future of the white-petaled, ruby-throated hibiscus may hinge on its past: The jury is still out on whether the showy plant is actually its very own species. Researchers will present their most recent findings on the matter on Tuesday, April 23, at the Experimental Biology 2013 conference in Boston.
A passing remark launched a project that will be described Monday, April 22, at the Experimental Biology 2013 conference. A poster, presented by researchers from Albany State University, has preliminary data that hint that there is an association between a rare pregnancy condition and malaria.
Researchers from Boston University School of Medicine have discovered that eating mushrooms containing vitamin D2 can be as effective at increasing and maintaining vitamin D levels in humans as taking supplemental vitamin D2 or vitamin D3. They’ll present their work Monday at the Experimental Biology 2013 conference in Boston.
When the space shuttle Atlantis touched down in the summer of 2011 at Cape Canaveral, closing the book on the U.S. shuttle program, a team of U.S. Army researchers stood at the ready, eager to get their gloved hands on a small device in the payload that housed a set of biological samples. On Monday at the Experimental Biology 2013 conference in Boston, the team will present the results of nearly two years’ worth of study on those samples, results that shed light on how the human immune system responds to stress and assaults while in space – and maybe here on Earth.
When thousands of researchers gather in Boston for the Experimental Biology 2013 conference this weekend, many of them undoubtedly will be presenting work related to the hunt for the next generation of antibiotics and how to battle back existing and emerging superbugs. But for one scientist from Texas Rio Grande Valley, it’s not about what the research of tomorrow holds: It’s about the kind of action the people in communities like his need today.
Regular use of low-dose aspirin may prevent the progression of breast cancer, according to a study by researchers at the Veterans Affairs Medical Center in Kansas City, Mo., and the University of Kansas Medical Center. They will present their results at the Experimental Biology 2013 conference in Boston on Sunday.
Snot. It’s not something most of us spend a lot of time thinking about, but, for a team of researchers in Washington, D.C., it’s front and center. The team’s lead researcher will present his newest study, focused on the molecules involved in cell signaling in nasal mucus, on Sunday at the Experimental Biology 2013 conference with the hope that other researchers present also will take the mission seriously, build upon his findings and come up with new therapies for patients, like his, struggling with smell loss.
Middle-school students from rural Maine will present at the Experimental Biology 2013 conference in Boston on Saturday a poster detailing how their involvement with the Tennessee-based Aspirnaut science-outreach program led to them becoming active scientific researchers.
Metformine, a widely used diabetic drug, might also be an effective and safe therapy for epilepsy, researchers report.
Autopsy data of 221 men and women found that the brains of one-third of individuals who had dementia before death showed evidence of small, cumulative blood vessel damage that can arise from hypertension or diabetes.
This April, Molecular & Cellular Proteomics will highlight some of the research presented at the 8th International Symposium on Mass Spectrometry in the Health and Life Sciences, held this past August in San Francisco. This Symposium described how recent advances in mass spectrometry have expanded our current knowledge about the vast protein networks inside cells and how they are regulated.
Researchers demonstrate both genetic and pharmaceutical evidence for the role of a protein called collagenase-2 in the development of multiple sclerosis (MS), providing a potential new way to combat this debilitating disease.
Researchers have provided a big new clue to help combat amyotrophic lateral sclerosis (ALS), deciphering that the dense protein aggregates that contribute to the nerve decay of ALS are composed of just one protein: superoxide dismutase (SOD1).
A new study provides more insight into cataracts, the leading cause of vision loss and blindness in the elderly, finding that small pieces of a perfectly normal protein become toxic during the aging process.
1) Bile Acids as Drug Candidates; 2) Transgenic Mice Don't Mind Cold Weather.
Animal models have been invaluable in understanding how gene mutations physically affect a complex organism. However, as illustrated in a new research study examining mice with a metabolic disease, the same mutation in the same species can produce wildly variable results.
1) Tracking a Deteriorating Heart; 2) Understanding Our Saliva
While a current belief is that nicotine receptor upregulation is independent of the type of nicotine receptor, researchers have now uncovered this is not the case: the transient and prolonged changes in the nicotine levels of smokers each affect a specific receptor subtype.
Ciliary neurotrophic factor (CNTF) has prompted much interest as a potential therapeutic agent. However, numerous experiments have met with limited success, until now; a research team shows that co-administrating CNTF with its receptor promotes the growth and survival of neurons.
1) Sodium, Calcium, Potassium and Skin Color; 2) How Embryonic Livers Store Energy.
A set of 15 proteins found in urine can distinguish healthy individuals from those who have coronary artery disease (CAD), reports a new study appearing in the february Molecular & Cellular Proteomics.
Statin drugs are helping many people lower their cholesterol, but a new study in the February Journal of Lipid Research reveals that statins actually increase the production of another protein that limits their benefit.
Treatment with the antibiotic myriocin can halt the growth of established arterial plaques in mice, researchers report.
1) Carbohydrate Regulates Stem Cell Potency; 2) Mechanism of SARS Lung Damage; 3) Structure of Important Psychiatric Enzyme Solved.
Researchers have undertaken a large-scale investigation into the molecular environment of the amyloid precursor protein (APP), a protein centrally associated with Alzheimer's disease.
The variation in human platelets in the elderly population is not significantly large, report researchers in a study that has strong implications for clinical biomarker research.
COX-2 inhibitors like Celecoxib have come under scrutiny lately due to adverse cardiovascular side-effects stemming from COX-2 reduction. In both fruit fly and rat models, researchers reveal another adverse effect of Celecoxib; this drug can induce arrhythmia. More interestingly, this effect is independent of the COX-2 enzyme.
Excess drinking of sugary beverages like soda may increase the risk of Alzheimer's disease, suggests new research in mice. Although the exact mechanisms aren't known, obesity and diabetes are both associated with higher incidences of Alzheimer's. Ling Li and her colleagues tested whether high sugar consumption in an otherwise normal diet would affect Alzheimer's progression.
1) Genetic Variants Affect Diet-Associated Cholesterol Metabolism; 2) Crohn's Disease Increases Progression of Atherosclerosis; 3) Breaking the Vicious Cycle of Bile Acid Disorders.
Rapid diagnostic testing used to check for the presence of prion diseases such as "mad cow disease" might fail to identify some highly infectious samples, researchers have found.
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