Scientists at Duke Health are part of a team that has discovered a type of cell surrounding blood vessels can also serve as a starting point for sarcoma, a form of cancer that occurs in bones and connective tissues.
Researchers at the Duke Clinical Research Institute (DCRI) and Vanderbilt University Medical Center (VUMC) have received a major federal grant to study how multisite clinical trials of new drugs and therapies in children and adults can be conducted more rapidly and efficiently.
Women who carry the BRCA1 gene mutation that dramatically increases their risk of breast and ovarian cancers are also at higher risk for a lethal form of uterine cancer, according to a study led by a Duke Cancer Institute researcher.
People with serious mental illnesses who use guns to commit suicide are often legally eligible to purchase guns, despite having a past record of an involuntary mental health examination and brief hospitalization, according to a new Duke Health analysis.
Scientists at the Duke Cancer Institute have identified a molecular key that breast cancer cells use to invade bone marrow in mice, where they may be protected from chemotherapy or hormonal therapies that could otherwise eradicate them.
A new mouse model of a genetically-linked type of autism reveals more about the role of genes in the disorder and the underlying brain changes associated with autism’s social and learning problems. Scientists at Duke Health who developed the new model also discovered that targeting a brain receptor in mice with this type of autism could ease repetitive behaviors and improve learning in some animals.
A new registry that launches this month gives women who have uterine fibroids the opportunity to help determine which strategies are most effective in treating the common condition.
A research team from Duke Health has developed an antibody from the body’s own immune system that preferentially attacks cancer cells. The antibody works by targeting a natural defense mechanism that cancer tumors exploit. Cells in the body essentially use a home security system that relies on certain proteins to protect the cell surface and keep it safe. These proteins help the cell avoid injury and even death from unwanted activation of the immune system.
Whether a child is complaining of intense stomach pain or has a head injury after a car crash, doctors may recommend a computed tomography, or CT scan, to investigate possible injuries. CT scans use ionizing radiation to create images of bones, organs, blood vessels and other soft tissues. The technology is widely available, provides quick and detailed results, and its use is growing worldwide, according to a recent report from the World Health Organization.
The alarming increase in U.S. childhood obesity rates that began nearly 30 years ago continues unabated, with the biggest increases in severe obesity, according to a study led by a Duke Clinical Research Institute scientist.
Giving early-stage prostate cancer patients a slightly higher daily dose of radiation can cut more than two weeks from the current treatment regimen without compromising cancer control, according to a national study led by a Duke Cancer Institute researcher.
Tests used to diagnose and assess the severity of coronary artery disease appear to function differently for women and men who have stable symptoms, according to researchers from Duke Clinical Research Institute.
Despite messages to the contrary, most women being seen by a doctor for the first time with suspected heart disease actually experience the same classic symptoms as men, notably chest pain and shortness of breath, according to a study led by the Duke Clinical Research Institute.
Most high-risk lung cancer patients might not need annual low-dose computed tomography (LDCT) screenings if they are cleared of disease in their initial test, according to a study led by a Duke Cancer Institute researcher.
Patients recovering from heart attacks or other heart trouble could cut their risk of another heart incident by half if they incorporate stress management into their treatment, according to research from Duke Health.
A new study from Duke Health suggests that patients who need to have their thyroid gland removed should seek surgeons who perform 25 or more thyroidectomies a year for the least risk of complications.
In the largest analysis of its kind, researchers at the Duke Cancer Institute and other top cancer centers have found that the organ site where prostate cancer spreads has a direct impact on survival.
Contralateral prophylactic mastectomies (CPMs) were associated with slightly higher satisfaction in women’s perception of how their breasts looked and felt, but primarily among women whose mastectomies were followed by reconstructive surgery.
One of the most crucial and elusive goals of an effective HIV vaccine is to stimulate antibodies that can attack the virus even as it relentlessly mutates. Now a research team, led by investigators at the Duke Human Vaccine Institute and the Vaccine Research Center of the National Institute of Allergy and Infectious Diseases (NIAID), has tracked rare potent antibodies in an HIV-infected individual and determined sequential structures that point to how they developed.
Neuroscientists at Duke Health have developed a brain-machine interface (BMI) that allows primates to use only their thoughts to navigate a robotic wheelchair.
Most doctors and nurses review a patient’s family history to identify risk factors for heart disease and cancer, often through a paper checklist or brief interview. But more deliberate efforts to map a patient’s family tree could identify additional risks and drive patients to timely screenings for illnesses that may unknowingly affect them, according to a new study from Duke Health.
The job market is luring more physician assistants, or PAs, to jobs in specialty care rather than primary care practices such as family medicine and general pediatrics, according to new research from Duke Health.
Swimmers and divers who are prone to a sudden and potentially life-threatening form of pulmonary edema in cold water could benefit from a simple and readily available dose of sildenafil, according to findings from a small study by Duke Health researchers.
Meditation eases anxiety, fatigue and pain for women undergoing breast cancer biopsies, according to researchers at the Duke Cancer Institute. They also found that music is effective, but to a lesser extent.
The first large U.S. study aimed at resolving an ongoing debate about the best way to treat an early sign of breast cancer will launch later this year under the direction of a Duke Cancer Institute investigator.
African-American patients with esophageal cancer survive fewer months after diagnosis than white patients, but only if they also have low incomes, according to a new study from Duke Health researchers.
Researchers at Duke Health are fine-tuning a test that can determine whether a respiratory illness is caused by infection from a virus or bacteria so that antibiotics can be more precisely prescribed.
When a child comes home from preschool with a stomach bug that threatens to sideline the whole family for days, why do some members of the family get sick while others are unscathed? According to a Duke Health study published January 19 in the Journal of Infectious Diseases, a person’s resistance to certain germs, specifically E. coli bacteria, could come down to their very DNA.
Researchers from the Duke Global Health Institute and their international collaborators are launching a study to find cost-effective ways of lowering blood pressure in adults living in rural in South Asia.
Doctors at the Duke University School of Medicine have tested a new injectable agent that causes cancer cells in a tumor to fluoresce, potentially increasing a surgeon’s ability to locate and remove all of a cancerous tumor on the first attempt. The imaging technology was developed through collaboration with scientists at Duke, the Massachusetts Institute of Technology (MIT) and Lumicell Inc.
Active surveillance could be a viable alternative to surgery and radiation for select patients with ductal carcinoma in situ, or DCIS, according to a mathematical model developed by researchers at Duke University.
Regions of the brain function differently among people with post-traumatic stress disorder, causing them to generalize non-threatening events as if they were the original trauma, according to new research from Duke Medicine and the Durham VA Medical Center.
Older women with early-stage, invasive breast cancer had better survival rates than what was estimated by a popular online tool for predicting survival, according to researchers at the Duke Cancer Institute.
The ROCKET AF Clinical Trial Executive Committee today announced its secondary analysis of the phase III trial (ROCKET AF) of the oral anticoagulant rivaroxaban. The analysis was prompted by a December 2014 FDA recall of a device used in the study.
Researchers from the Duke-NUS Graduate Medical School Singapore (Duke-NUS) and Duke Medicine have identified a potential treatment strategy for an often-fatal inherited glycogen storage disease.
Being bullied in childhood has been associated with increased risk for anxiety, depression and even eating disorders. But according to new research, it’s not only the victims who could be at risk psychologically, but also the bullies themselves.
Heart patients who had undergone an angioplasty procedure that opened only some blocked arteries tended to have a resolution of their chest pain, making it unnecessary to add another medication to treat the symptom, according to a study led by the Duke Clinical Research Institute.
Despite efforts to increase gender diversity in cardiology, major differences in job characteristics and pay persist between men and women who treat heart patients, according to a Duke Medicine-led study presented at the annual American Heart Association meeting.
Studies have demonstrated how just a few sessions of binge drinking during adolescence can knock out neurons (shown in blue arch) in the hippocampus, the brain’s memory core.
Used alone, a cell phone app that tracks exercise, calories and weight loss goals is, on average, not enough to create meaningful weight loss in young adults, according to new research from Duke Medicine.
Researchers at Duke Medicine have discovered that rhesus monkeys can, in fact, transmit Cytomegalovirus (CMV) across the placenta to their unborn offspring. This finding, reported online October 19 in the Proceedings of the National Academy of Sciences, establishes the first primate model that researchers can use to study mother-to-fetus CMV infections and spur development of potential vaccine approaches.
Drug-resistant E. coli infections are on the rise in community hospitals, where more than half of U.S. patients receive their health care, according to a new study from Duke Medicine.
Treatment patterns for ductal carcinoma in situ (DCIS) have shifted since the 1990s, with more U.S. women opting for lumpectomy in combination with radiation rather than single-breast mastectomy, according to a study lead by Duke Cancer Institute researchers. But the researchers also found an increased tendency for women to seek removal of both breasts, despite their analysis that cancer survival rates remained similar regardless of the form of treatment.
In a hospital, what you can’t see could hurt you. Healthcare facilities continue to battle drug-resistant organisms such as methicillin-resistant Staphylococcus aureus (MRSA) that loiter on surfaces even after patient rooms have been cleaned and can cause new, sometimes-deadly infections. But a new study from Duke Medicine has found that using a combination of chemicals and UV light to clean patient rooms cut transmission of four major superbugs by a cumulative 30 percent among a specific group of patients -- those who stay overnight in a room where someone with a known positive culture or infection of a drug-resistant organism had previously been treated.
Tick tock. Tick tock. A team of scientists from Duke-NUS Graduate Medical School Singapore (Duke-NUS) and the University of Michigan at Ann Arbor have discovered a molecular switch that regulates the body’s circadian clock and allows it to keep time. This switch could be a potential drug target to treat circadian rhythm disorders caused by jet lag, shift work or metabolic disorders.
Scientists at Duke Medicine are using transparent fish to watch in real time as Cryptococcal meningitis takes over the brain. The resulting images are worthy of a sci-fi movie teaser, but could be valuable in disrupting the real, crippling brain infection that kills more than 600,000 people worldwide each year.
A unique molecule developed at Duke Medicine, the University of North Carolina at Chapel Hill and MacroGenics, Inc., is able to bind HIV-infected cells to the immune system’s killer T cells. It could become a key part of a shock-and-kill strategy being developed in the hope of one day clearing HIV infection.
Researchers at Duke Medicine and the University of Alberta are reporting the identification of a new biochemical pathway to control insulin secretion from islet beta cells in the pancreas, establishing a potential target for insulin control.
Scientists at Duke University have released a highly detailed model of connections in the mouse brain that could provide generations of neuroscientists new insights into brain circuits and origins of mental illness, such as depression and schizophrenia. The findings are published in the journal Cerebral Cortex.
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