Two units of plasma given in a medical helicopter on the way to the hospital could increase the odds of traumatically injured patients with severe bleeding surviving by 10 percent, according to the results of a national clinical trial.
A gene linked to 3 to 4 percent of people with Parkinson’s disease could play an important role in most, if not all, people with the disease, according to a new study. The findings suggest that treatments being developed for this small group of people may benefit many more patients than previously thought.
More than one in 10 children hospitalized with sepsis die, but when a series of clinical treatments and tests is completed within an hour of its detection, the chances of survival increase considerably.
Postmenopausal factors may have an impact on the heart-protective qualities of high-density lipoproteins (HDL) – also known as ‘good cholesterol.’ The findings bring into question the current use of total HDL cholesterol to predict heart disease risk.
Several states are likely dramatically underestimating the effect of opioid-related deaths because of incomplete death certificate reporting, with Pennsylvania leading the pack.
New research from the University of Pittsburgh School of Medicine shows that white bloods cells, which typically heal infections and injuries, can become overactive and cause inflammation in plaques in blood vessels, making them vulnerable to rupture and hemorrhage in people with diabetes.
Center will help diagnose diseases, advance immunotherapy research and guide treatment choices.
In the first 90 days of concurrent opioid and benzodiazepine use, the risk of opioid-related overdose increases five-fold compared to opioid-only use among Medicare recipients, according to a new study from the University of Pittsburgh School of Pharmacy.
Doctors found that cases of Lyme disease in children have increased exponentially in western Pennsylvania.
The University of Pittsburgh School of Medicine has been awarded a five-year, $5 million award to create an elite training program designed to set newly minted physicians on a career path that integrates scientific research with clinical care.
Mucus and other airway secretions that are expelled when a person with the flu coughs or exhales appear to protect the virus when it becomes airborne, regardless of humidity levels, a creative experiment conducted by the University of Pittsburgh and Virginia Tech discovered.
Negative experiences on social media carry more weight than positive interactions when it comes to the likelihood of young adults reporting depressive symptoms, according to a new University of Pittsburgh analysis.
Families of critically ill hospital patients report higher satisfaction with clinician communication and a better perception of patient-centered care when the care team uses a low-cost strategy involving intensive emotional support and frequent meetings.
Overall antibiotic use was not curbed by giving physicians the results of biomarker tests in patients with suspected lower respiratory tract infections, according to findings from the Procalcitonin Antibiotic Consensus Trial.
Smoking tobacco from a waterpipe, also known as a hookah, accounted for over half of the tobacco smoke volume consumed by young adult hookah and cigarette smokers in the U.S.
On May 6, the National Institutes of Health will open national enrollment for the All of Us Research Program in collaboration the University of Pittsburgh and other partners.
The past quarter century has brought a striking decline in earlier-than-expected deaths among blacks in the U.S., according to a first-of-its-kind analysis performed using an extensive death records database maintained by the University of Pittsburgh Graduate School of Public Health.
PAs increasingly used in dermatology to cut costs and improve access, but are less likely than dermatologists to accurately diagnose early stage skin cancers, according to new research.
In response to repeated calls for an integrated emergency care system in the U.S., the University of Pittsburgh rose to the challenge and divided the nation into hundreds of referral regions that describe how patients access advanced care, in a way that respects geopolitical borders.
A distinguished molecular virologist will lead the University of Pittsburgh’s Center for Vaccine Research, which focuses on the development of diagnostics, therapeutics and vaccines for infectious diseases that pose risks to global public health.
Proposals may come from any relevant biological discipline and should include a component of early human development, and/or a longitudinal, lifespan approach to any project within the reproductive sciences and women’s health.
Pitt and UPMC researchers showed how a common virus hijacks a host cell’s protein to assemble new viruses.
Immunotherapy does not work for a majority of cancer patients. Preventing or reversing metabolic exhaustion in cancer-killing T-cells could boost its effectiveness.
Critically ill patients who experience long periods of hypoxic, septic or sedative-associated delirium, or a combination of the three, during an intensive care unit (ICU) stay are more likely to have long-term cognitive impairment one year after discharge from the hospital, according to a new study.
A new blood test seems to perform as well as, if not better than, traditional blood cultures at detecting a type of fungal yeast infection that commonly strikes hospital patients, according to a national trial.
New collaborative research signals a potential breakthrough for adults with autism spectrum disorder.
For the first time researchers have identified recurrent ESR1 fusion proteins in human breast cancer, to understand how they function and help lead to improved treatments for the disease.
In just two years, the powerful opioid fentanyl went from nonexistent to detected in more than 1 in 7 stamp bags analyzed by the Allegheny County Office of the Medical Examiner.
Requiring physicians to report patients with dementia to state driver’s licensing authorities is not associated with fewer hospitalizations from motor vehicle crashes. However, in-person license renewal laws and vision testing dramatically cut crashes involving drivers with dementia.
Half of sepsis survivors never fully recover; Dr. Derek Angus lays out an approach to change that.
Playing an adventure video game featuring a fictitious, young emergency physician treating severe trauma patients was better than text-based learning at priming real doctors to quickly recognize the patients who needed higher levels of care, according to a new trial. The game tackles the annual problem of 30,000 preventable deaths occurring after injury, in part because severely injured patients aren't promptly transferred to trauma centers.
Young adults who use electronic cigarettes are more than four times as likely to begin smoking tobacco cigarettes within 18 months as their peers who do not vape, according to new University of Pittsburgh research. The findings demonstrate that e-cigarettes are serving as a gateway to traditional smoking, contrary to their purported value as a smoking cessation tool. The study is the first nationally representative survey that followed for more than a year people 18 to 30 years old who were initially nonsmokers.
SW Pennsylvania far exceeds national averages for telltale signs of the stress and risk faced by caregivers.
A common, hands-on method for teaching genetics in grade school encourages students to compare their earlobes with those of their parents: Are they attached and smoothly mesh with the jawline? Or are they detached and dangly? The answer is meant to teach students about dominant and recessive genes. Simple, right? Not so fast.
When low-income adults were newly covered by Medicaid under the Affordable Care Act (ACA), they were more likely to quit smoking cigarettes than their counterparts in states that did not offer Medicaid expansion. The findings support a policy-driven approach to reduce high smoking rates among low-income adults by giving greater access to smoking cessation programs.
When low-income parents enroll in Medicaid through the Affordable Care Act (ACA) state expansion program, their children have considerably better odds of receiving annual preventive care pediatrician visits. This “spillover effect" demonstrates that the potential benefits of Medicaid expansion extend beyond the newly covered adults.
A procedure to remove clots from blocked brain vessels – known as thrombectomy - may be beneficial for some stroke patients even if they come in to the emergency room beyond the 6-hour treatment window that current guidelines endorse, according to a groundbreaking study conducted by an international team of physicians and researchers.
Although studies and surveys have shown that using information technology to analyze big health datasets and guide public health decisions can improve health equity, the majority of community health center leaders and staff report receiving little to no training in health informatics. Today at the American Public Health Association Annual Meeting in Atlanta, the University of Pittsburgh Graduate School of Public Health will share a training protocol designed to remedy this gap and be replicated nationwide.
Embedding a decision support tool in the hospital electronic health record increases detection of acute kidney injury, reducing its severity and improving survival. The results address one of the most costly and deadly conditions affecting hospitalized patients, providing evidence that computers analyzing changes in renal function can alert doctors of acute kidney injury before the condition is obvious clinically.
University of Pittsburgh scientists are unlocking the complexities of a recently discovered cell death process that plays a key role in health and disease, and new findings link their discovery to asthma, kidney injury and brain trauma. The results, reported today in the journal Cell, are the early steps toward drug development that could transform emergency and critical care treatment.
Researchers from the University of Pittsburgh and UPMC analyzed existing evidence and found that patients living with heart failure receive palliative care significantly less often than patients with other illnesses, despite evidence that such care improves symptom management and quality of life.
PancreaSeq® analyzed mutations known to be associated with precursors to pancreatic cancers.
UPMC has taken a 50 percent stake in Salvator Mundi International Hospital and will expand specialized services.
Expanding the high-dose influenza vaccine recommendation to include middle-aged adults with chronic health conditions may make economic sense and save lives. The findings may justify for clinical trials of the high-dose and new recombinant trivalent influenza vaccines in 50- to 64-year-old adults with chronic illnesses, such as heart or lung disease, diabetes, or cancer, to determine if they do provide considerably better protection than the currently recommended standard dose quadrivalent vaccine.
Antibody treatment reduces rate of flare-ups in patients with a subgroup of treatment-resistant COPD.
Scientists may have found a clue to why people living with HIV have double the likelihood of developing heart disease. The findings, made by researchers at the University of Pittsburgh Center for Vaccine Research and National Institutes of Health, also show that an experimental drug may hold promise as a potential treatment.
Workers in the hardmetal industry are not at increased risk for lung cancer or any of 63 other potential causes of death, concluded the largest and most definitive study on this population to date. The study of more than 32,000 workers in five countries was performed after smaller French and Swedish studies indicated that tungsten carbide with a cobalt binder – the primary ingredients in hardmetal – may be linked to an increased risk of lung cancer.
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