A new study in animal models, led by scientists at The Scripps Research Institute (TSRI), suggests that the eye's lacrimal glands can be repaired by injecting a kind of regenerative “progenitor” cell.
Scientists at The Scripps Research Institute have created a ribozyme that can basically serve both to amplify genetic information and generate functional molecules, a big step toward the laboratory re-creation of the “RNA world,” generally believed to have preceded modern life forms based on DNA and proteins.
A new study from scientists at The Scripps Research Institute, funded by the National Institute on Drug Abuse and National Institute on Alcohol Abuse and Alcoholism, suggests increased levels of a molecule in the brain, called hypocretin, may contribute to cocaine addiction.
Scientists at The Scripps Research Institute now have a high-resolution view of exactly how the experimental therapy ZMapp targets Ebola virus.
A new study, led by scientists at The Scripps Research Institute, reveals a surprising twist in immune biology, suggesting that members of a cluster of microRNAs work together throughout the different stages of immune cell generation.
A new international collaboration involving scientists at The Scripps Research Institute opens a door to influencing the immune system, which would be useful to boost the effectiveness of vaccines or to counter autoimmune diseases such as lupus and rheumatoid arthritis.
A new study has shown that a new class of drug candidates developed at The Scripps Research Institute increases bone mass by expanding bone formation (deposition of new bone) and bone turnover (a normal process of replacement of old bone).
Scientists at The Scripps Research Institute (TSRI) and Scripps Clinic have received a grant of nearly $2.4 million from the California Institute for Regenerative Medicine (CIRM) to support safety and quality tests of a potential stem cell therapy for Parkinson’s disease.
In a new study, scientists at The Scripps Research Institute have identified drug candidates that can boost a cell’s ability to catch the “typos” in protein production that can cause a deadly disease called amyloidosis, revealing a new approach to intervene in human disease.
A study from scientists at The Scripps Research Institute reveals the role of the gene Mkx in maintaining and strengthening tendons in animal models; the gene also appears to prevent a debilitating tendon condition called “ossification.”
Scientists from the Florida campus of The Scripps Research Institute have shown for the first time that ensembles of genes within the striatum could be deeply involved in bipolar disorder.
As part of the most ambitious medical research program in the history of American medicine, The Scripps Research Institute has received an initial award of $20 million for its role in a national precision medicine initiative, the National Institutes of Health announced today.
Two new studies led by scientists at The Scripps Research Institute advance efforts to produce HIV vaccine candidates, potentially suitable for large-scale production.
Chemist Phil Baran of The Scripps Research Institute has won a 2016 Blavatnik National Award for Young Scientists. Blavatnik National Awards are granted to only three individuals each year, one in each of the fields of physical science/engineering, chemistry, and life science.
Scientists at The Scripps Research Institute have identified a protein that launches cancer growth and appears to contribute to higher mortality in breast cancer patients. The new findings suggest that future therapies might target this protein, called GlyRS, to halt cancer growth.
A team of scientists at The Scripps Research Institute (TSRI), University of California, San Diego (UC San Diego) and Illumina, Inc., has completed the first large-scale assessment of single neuronal “transcriptomes.”
Scientists at The Scripps Research Institute have developed a powerful new method for finding drug candidates that bind to specific proteins, an advance that can be applied to a large set of proteins at once, even to the thousands of distinct proteins directly in their native cellular environment.
Scientists from the Florida campus of The Scripps Research Institute have been awarded $1.3 million by the National Cancer Institute of the National Institutes of Health to develop novel compounds to enhance the immune system of patients with cancer.
Matthew Disney, professor on the Florida campus of The Scripps Research Institute (TSRI), and Phil Baran, Darlene Shiley Professor of Chemistry on the California campus of TSRI, have been named chemistry finalists for the 2016 Blavatnik National Awards for Young Scientists.
A study by scientists at The Scripps Research Institute Florida campus uncovers a new aspect of how the process of forgetting works, indicating a protein called “Scribble” orchestrates the intracellular signaling processes for forgetting, joining several molecules to forge a pathway.
he Skaggs family has given a new $2 million gift to support exceptional students in The Scripps Research Institute graduate program.
The Scripps Research Institute has named Richard A. King, formerly president and CEO of AcelRx Pharmaceuticals, Inc., as chief operating officer.
Scientists from the Florida campus of The Scripps Research Institute have for the first time created a drug candidate that attacks and neutralizes the RNA structure that causes an incurable progressive, inherited disease involving a gradual loss of control over body movement.
Scientists at The Scripps Research Institute have caught a cancer-causing mutation in the act. A new study shows how a gene mutation found in several human cancers, including leukemia, gliomas and melanoma, promotes the growth of aggressive tumors.
A study from The Scripps Research Institute suggests external stimulation guides certain neurons’ early development so that inhibitory neurons split into two different types of neurons, each with a different job, adding another level of complexity and regulation to the brain’s circuitry.
Scientists from The Scripps Research Institute Florida campus have found that one of the most widely prescribed pain and anti-inflammation drugs slows the growth rate of a specific kind of cancer in animal models and suggests the medication could have the same effect on other types of tumors.
A team led by scientists at The Scripps Research Institute has invented a method for rapidly identifying venoms that strike a specific target in the body—and optimizing such venoms for therapeutic use.
A team of scientists at The Scripps Research Institute is expanding web services to make biomedical research more efficient. With their free, public projects, MyGene.info and MyVariant.info, researchers around the world have a faster way to spot new connections between genes and disease.
In a pair of studies, chemists from the Florida campus of The Scripps Research Institute have identified and designed dozens of molecular “warheads” that not only can detect a key biomarker of cancer, but also could be developed into a potent new class of drug candidates for a range of diseases.
Scientists from the Florida campus of The Scripps Research Institute have for the first time designed a drug candidate that decreases the growth of tumor cells in animal models in one of the hardest to treat cancers—triple negative breast cancer.
Scientists from the Florida campus of The Scripps Research Institute have been awarded a $2.5 million grant from the National Institute of General Medical Sciences of the National Institutes of Health to design precision drug candidates that target disease-associated RNAs.
Loss of appetite during illness is common and potentially debilitating; in cancer patients, especially, it can even shorten lifespan. Scientists at The Scripps Research Institute have discovered how an immune system molecule hijacks a brain circuit and reduces appetite.
Scientists from The Scripps Research Institute’s Florida campus have shown how sometimes small, often imperceptible, structural changes in a key breast cancer receptor are directly linked to regulating molecules and can produce predictable effects in curbing or accelerating cancer growth.
A group including scientists at The Scripps Research Institute Florida campus has been awarded a grant from the National Institute of Neurological Disorders to study the role of microRNAs in a range of physiological activities, including memory, sleep, synapse function and movement.
Scientists at The Scripps Research Institute have solved the structure of the biological machinery used by a common virus to recognize and attack human host cells. The new structure gives scientists the first view of the glycoprotein of lymphocytic choriomeningitis virus.
Scientists at The Scripps Research Institute have devised a new molecule-building method likely to have a major impact on the pharmaceutical industry and other chemistry-based enterprises. The method allows construction of novel, complex and potentially valuable molecules.
An eight-year-long accrual and analysis of the whole genome sequences of healthy elderly people, or “Wellderly,” has revealed a higher-than-normal presence of genetic variants offering protection from cognitive decline, researchers from the Scripps Translation Science Institute reported.
Scientists at The Scripps Research Institute have found a new and better way to achieve a chemical reaction that is used widely in the pharmaceutical as well as flavor and fragrance industries.
Scientists at The Scripps Research Institute have integrated biomedical data into Wikidata, a public, editable database where researchers can easily link genes, proteins and more.
Scientists from the Florida campus of The Scripps Research Institute have identified a unique memory suppressor gene in the brain cells of Drosophila, the common fruit fly, a widely recognized substitute for human memory studies.
Scientists at The Scripps Research Institute (TSRI) and collaborating institutions have described the first-ever immature or “teenage” antibody found in a powerful class of immune molecules effective against HIV.
A new study led by scientists at The Scripps Research Institute reveals a previously unknown type of immune cell. The discovery opens new avenues in the effort to develop novel therapies for autoimmune diseases such as type 1 diabetes.
A team from the Florida campus of The Scripps Research Institute (TSRI) and the University of North Carolina (UNC) has been awarded $3.4 million from the National Institute on Drug Abuse of the National Institutes of Health (NIH) to develop novel therapeutics for the treatment of addiction and mood disorders.
In a new study, researchers at The Scripps Research Institute report that, based on its structure, a hollowed-out version of the cowpea mosaic virus, a plant pathogen that can be modified to aid in tumor detection and chemotherapy, could also be effective in human therapies.
A team led by scientists at The Scripps Research Institute and the Salk Institute for Biological Studies has discovered two enzymes that appear to play a role in metabolism and inflammation—and might someday be targeted with drugs to treat type 2 diabetes and inflammatory disorders.
In a landmark feat of chemical synthesis, scientists at The Scripps Research Institute have developed a 19-step process for making the naturally occurring compound phorbol in the laboratory, in quantities that are useful for pharmaceutical research.
Scientists from the Florida campus of The Scripps Research Institute have received a $1.4 million grant from the Department of Defense to develop a series of drug candidates that act against molecules closely linked with the growth of cancer cells.
A study led by scientists at The Scripps Research Institute (TSRI) shows that genome-wide molecular profiling of kidney biopsies may be a key to catching organ rejection before it’s too late.
A new study led by scientists at The Scripps Research Institute suggests that cells construct protein “clumps” to protect against neurodegenerative diseases such as amyotrophic lateral sclerosis, a.k.a. ALS or Lou Gehrig’s disease.
A new study by scientists from the Florida campus of The Scripps Research Institute has identified specific genetic variations closely associated with increased susceptibility to bipolar disorder and other conditions. The discovery may provide a target for new therapies.
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