The California Institute for Regenerative Medicine has awarded UC San Diego researchers $4.8 million to advance a gene therapy to treat Friedreich’s ataxia, a rare but devastating neuromuscular disorder.
Engineers developed a battery-free, pill-shaped ingestible biosensing system that gives scientists the ability to monitor gut metabolites in real time, which wasn’t possible before. The work could lead to a new understanding of intestinal metabolite composition, which significantly impacts human health.
UC San Diego researchers identify the PKCα enzyme as a promising therapeutic target in Alzheimer’s disease; a mutation that increases its activity led to biochemical, cellular and cognitive impairments in mice.
Both Democrats and Republicans would rather take away funding from their political party than give money to the other party, reveals a new University of California San Diego Rady School of Management study. The research also assesses people’s preferences regarding two other contentious issues—gun rights and reproductive rights—and finds the same result: people would rather hurt the cause they believe in than support one they oppose.
Nanoengineers at the University of California San Diego’s Jacobs School of Engineering have developed an AI algorithm that predicts the structure and dynamic properties of any material—whether existing or new—almost instantaneously. Known as M3GNet, the algorithm was used to develop matterverse.ai, a database of more than 31 million yet-to-be-synthesized materials with properties predicted by machine learning algorithms. Matterverse.ai facilitates the discovery of new technological materials with exceptional properties.
The University of California San Diego has been named the No. 29 university in the world, climbing five spots globally in the Times Higher Education World Reputation Rankings 2022.
The UC San Diego Sanford Stem Cell Institute leads its first space launch, sending stem cells into space aboard the International Space Station. The NASA-partnered study will take advantage of the microgravity environment of space to study accelerated aging in stem cells.
UC San Diego Alpha Stem Cell Clinic awarded $8M to expand clinical trials of novel stem cell therapies. The CIRM award will advance partnerships between academic and industry experts in San Diego to expedite clinical trials for patients with difficult-to-treat diseases.
UC San Diego researchers discuss how mimicking sleep patterns of the human brain in artificial neural networks may help mitigate the threat of catastrophic forgetting in the latter, boosting their utility across a spectrum of research interests.
UC San Diego researchers used human brain organoids to study the effects of prenatal alcohol exposure on neural development, revealing significant harms in molecular detail.
Engineers and physicians at UC San Diego have developed a device to non-invasively measure cervical nerve activity in humans, a new tool they say could potentially inform and improve treatments for patients with sepsis or post-traumatic stress disorder.
UC San Diego researchers expand and deepen understanding of how genetic aberrations fuel human papilloma virus-negative head and neck cancers and, potentially, provide paths to further refinement and improvement of immune checkpoint inhibitors for HPV-negative head and neck cancers.
The award winners, including San Diego Supercomputer Center at UC San Diego, have been recognized in the annual HPCwire Readers’ and Editors’ Choice Awards, presented at the 2022 International Conference for High Performance Computing, Networking, Storage, and Analysis (SC22), in Dallas, Texas.
Using human brain organoids, an international team of researchers has shown how the SARS-CoV-2 virus that causes COVID-19 infects cortical neurons and specifically destroys their synapses — the connections between brain cells that allow them to communicate with each other.
Uncertainty is bad for business; however, it can be mitigated by trade agreements which help countries become more resilient to economic shocks, according to a new University of California School of Global Policy and Strategy study.
Researchers at UC San Diego School of Medicine and Moores Cancer Center at UC San Diego Health describe the first preclinical model of appendiceal cancer that contains all elements of the tumor, allowing previously stymied investigations to proceed.
Researchers at UC San Diego report that a polygenic hazard score based on 290 genetic variants could be an effective tool for predicting genetic risk of lethal prostate cancer, which kills more than 34,000 men in the U.S. annually.
UC San Diego researchers and others report that more than one-third of the COVID-19 patients who did not receive any treatment experienced complete resolution of symptoms for at least two consecutive days, but then subsequently reported a return of symptoms.
In animal models, UC San Diego researchers found that intensive physical therapy in tandem with implanted neural stem cells increased tissue growth, repair and functionality in spinal cord injuries more than those treatments alone
The University of California San Diego has been ranked among the top 20 universities in the world, according to U.S. News and World Report’s 2022-2023 Best Global Universities.
UC San Diego will be one of multiple sites assessing the safety and efficacy of tecovirimat as a potential treatment for human monkeypox. Marketed as TPOXX, tecovirimat is an antiviral currently approved for treatment of human smallpox in adults and children caused by the variola virus.
Researchers at UC San Diego have identified a new signaling process involving G protein-coupled receptors (GPCRs), a cellular target already exploited by hundreds of diverse drugs. The discovery opens the possibility of new therapies, including for multiple forms of cancer.
Building upon a long history, the UC San Diego has launched a new Human Milk Institute to accelerate research into the nature, biology and therapeutic potential of human milk to prevent or treat both infant and adult diseases. The new institute is believed to be the first of its kind in the United States.
Using a novel systems biology approach, scientists at UC San Diego School of Medicine have further parsed the cellular players and roles involved in rheumatoid arthritis, a complex disease that affects more than one million Americans in ways that have defied development of uniform treatments.
Experts at the San Diego Supercomputer Center at UC San Diego, San Diego State University and California State University, San Bernardino will apply NSF support to train and mentor a cohort of cyberinfrastructure professionals who will work closely with scientists to meet their computational needs.
Victor Nizet, MD, Distinguished Professor of Pediatrics at UC San Diego School of Medicine and Pharmacy at Skaggs School of Pharmacy and Pharmaceutical Sciences at UC San Diego, has been elected to the National Academy of Medicine.
UC San Diego scientists are leading a national early-stage clinical trial to assess the safety and efficacy of using bacteriophages to treat drug-resistant bacterial infections in cystic fibrosis patients.
From robots inspired by animals and even amoeba, to better algorithms for self-driving cars and robotic surgery, researchers at the University of California San Diego will be presenting a wide range of papers at IROS 2022, which returns in a hybrid format Oct. 23 to 27, 2022.
Facing extreme conditions such as starvation and stress, some bacterial cells enter a dormant state in which life processes stop. Biologists have discovered how they assess environmental conditions for a return to life, carrying implications for evaluating life on Earth as well as other planets.
UC San Diego researchers discover that quality and mix of protein in a type of pancreatic cancer is the determinant of whether the prognosis is poor or very poor.
A new system of algorithms developed by UC San Diego engineers enables four-legged robots to walk and run on challenging terrain while avoiding both static and moving obstacles. The work brings researchers a step closer to building robots that can perform search and rescue missions or collect information in places that are too dangerous or difficult for humans.
UC San Diego study finds enhanced PKCγ activity drives spinocerebellar ataxia type 14; suggests inhibiting the enzyme may have therapeutic potential
An international team of scientists, co-led by researchers at the University of California San Diego School of Medicine, has created the first pan-cancer mycobiome atlas — a survey of 35 types of cancer and their associated fungi
Through a highly competitive process, the Department of Energy (DOE) has announced $12.6 million in renewed funding for Quantum Materials for Energy Efficient Neuromorphic Computing (Q-MEEN-C) — led by the University of California San Diego.
In the first known study of its type, an international team of researchers evaluated whether high research and development costs explain high drug prices in the United States. They found no such association for 60 new drugs approved from 2009 to 2018.
UC San Diego researchers have for the first time discovered a pattern of DNA mutations that links bladder cancer to tobacco smoking. The work could help researchers identify what environmental factors, such as exposure to tobacco smoke and UV radiation, cause cancer in certain patients. It could also lead to more customized treatments for a patient’s specific cancer.
New center will focus on enabling high-performance molecular dynamics simulations via oneAPI—an open, standards-based, cross-architecture programming model for CPUs and accelerators for faster application performance, more productivity and greater innovation.
Researchers at UC San Diego have used artificial intelligence-guided tools to pinpoint both a specific type of immune cell as the driver of esophageal cancer and a specific genetic variation that acts as a protective factor in African Americans.
UC San Diego engineers have developed microscopic robots, called microrobots, that can swim around in the lungs, deliver medication and be used to clear up life-threatening cases of bacterial pneumonia. In mice, the microrobots safely eliminated pneumonia-causing bacteria in the lungs and resulted in 100% survival. By contrast, untreated mice all died within three days after infection.
Seeking solutions to counteract a rapid rise in plastic trash, scientists at UC San Diego have developed biodegradable material that is designed to replace conventionally used plastic. In a new study, an interdisciplinary team of researchers has shown that the material biodegrades in seawater.
With a $126 million grant from the National Institutes of Health, a multi-institution team of researchers at UC San Diego, Salk Institute and elsewhere has launched a new Center for Multiomic Human Brain Cell Atlas to describe human brain cells in unprecedented detail over a lifetime.
A national team of scientists, led by researchers at UC San Diego, have created a machine-learning algorithm for diagnosing both MIS-C and Kawasaki disease, two similar pediatric inflammatory conditions with different treatments.
UC San Diego researchers developed soft devices containing algae that glow in the dark when experiencing mechanical stress, such as being squished, stretched, twisted or bent. The devices do not need electronics to produce light, making them ideal for building soft robots for exploring the deep sea and other dark environments.
The current U.S. trajectory to decouple from China on clean energy technologies can harm national and global efforts to mitigate climate change, reveals a new University of California San Diego study published in Science.
A UC San Diego study identifies neural mechanisms contributing to poorer cognition in aging adults; results may inspire new clinical interventions
UC San Diego scientists will lead several components of Bridge2AI, a new NIH-funded program to promote the use of AI in health and research.
The sociopolitical climate in the United States has taken its toll on the mental health of Latina mothers, according to new research from the University of California San Diego. Findings show increased depression, anxiety and perceived stress in a border city and reduced coping resources in both a border and interior US city.
Much of the world’s efforts to mitigate the effects of climate change hinge on the success of the landmark 2015 Paris Agreement. A new Nature Climate Change study is the first to provide scientific evidence assessing how effective governments will be at implementing their commitments to the agreement that will reduce CO2 emissions causing climate change.
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