For the first time, researchers at the University of North Carolina at Chapel Hill show how the antiviral class of drugs called NS5A inhibitors interacts with the hepatitis C virus, and these findings show a difference between strains of HCV. These results were published in PLOS Pathogens.
In two previous studies, University of North Carolina researchers and colleagues linked infant brain anatomy differences to autism diagnoses at age two. Now they show differences in functional connections between brain regions at 6 months to predict autism at age two.
UNC Lineberger Comprehensive Cancer Center surveyed 1,171 men diagnosed with prostate cancer in North Carolina, finding that while both white and black men were concerned about curing their cancer and the quality-of-life impacts of treatment, more black men considered other social and personal factors -- such as recovery time and cost -- to be very important in their treatment decision-making.
In preliminary findings (abstract 6510) that will be presented at the American Society of Clinical Oncology Annual Meeting 2017 in Chicago on Saturday, June 3, researchers show that when physicians had to choose between multiple, on-patent drugs for metastatic kidney cancer and chronic myeloid leukemia, they were more likely to prescribe drugs from companies they had received general payments from.
Every animal starts as a clump of cells, which over time multiply and mature into many different types of cells, tissues, and organs. This is fundamental biology. Yet, the details of this process remain largely mysterious. Now, scientists have begun to unravel an important part of that mystery.
For the first time, UNC School of Medicine researchers show that exercising burns the fat found within bone marrow and offers evidence that this process improves bone quality and the amount of bone in a matter of weeks.
A special issue of the Journal of Infectious Diseases focuses solely on HIV eradication and is edited by the director of the UNC HIV Cure Center in Chapel Hill.
Researchers report in the Journal of the American Medical Association Internal Medicine that providing one-on-one support and customized tools for decision-making increased screening rates for patients at two community health centers in North Carolina and New Mexico.
In a pair of studies published in the journal Neuro-Oncology, UNC Lineberger Comprehensive Cancer Center researchers and collaborators report on the genetic evolution of glioblastoma as it progresses in severity and a potential strategy to treat this often fast-growing brain cancer type.
In findings published in the journal Cancer, Epidemiology, Biomarkers & Prevention, UNC Lineberger Comprehensive Cancer Center researchers confirmed the link between alcohol consumption and breast cancer risk in a study in black women. The association has been seen in other studies drawn from majority white populations.
The UNC School of Medicine today launched the Android version of PPD ACTTM, a mobile app-based study helping to further the understanding of why some women suffer from Postpartum Depression (PPD) and others do not – critical knowledge for researchers working to find more effective treatments.
UNC Lineberger Comprehensive Cancer Center researchers report in a new study that anti-tanning bed messages with images showing longer-term health effects, such as skin cancer or wrinkles, produced greater negative emotional reactions and higher ratings of effectiveness in a survey of female college students than text-only messages.
Researchers at the UNC School of Medicine are working to develop a test for the Zika virus that they hope will provide accurate results for a wide range of time between when an individual is potentially exposed to when he or she is tested for the virus.
Every year, falls lead to hospitalization or death for many elderly Americans. Standard clinical techniques generally cannot diagnose balance impairments before they lead to falls. But researchers now think virtual reality could be a big help in detecting and possibly reversing balance impairments.
A UNC research team has identified a new cell in the body where HIV persists despite treatment. This discovery has major implications for cure research.
Researchers from UNC-Chapel Hill, the National Cancer Institute and Centers for Disease Control and Prevention, reported preliminary findings at the American Association for Cancer Research Annual Meeting April 5 that the total number of HIV-positive cancer patients in the United States is projected to decrease through 2030. The researchers also projected that there would be a decrease in cancers linked to the advanced stage of HIV infection -- AIDS.
In preliminary findings that will be presented Sunday, April 2, at the American Association for Cancer Research Annual Meeting 2017, UNC Lineberger Comprehensive Cancer Center researchers report on a preclinical study into the use of nanoparticles to improve the efficacy of immunotherapy drugs known as checkpoint inhibitors.
In an abstract that will be presented at a poster session to be held from 1 to 5 p.m. April 3 at the American Association for Cancer Research Annual Meeting 2017, UNC Lineberger Comprehensive Cancer Center researchers will report their preliminary findings that breast cancer cancer cells grew larger when they were transplanted into fatty, obese tissue.
A UNC Lineberger Comprehensive Cancer Center-led study found broad support, even among smokers, for increasing the size of health warnings on cigarette packs.
With a more accurate understanding of the characteristics and function of the receptor MRGRPX2, University of North Carolina School of Medicine researchers were also able to create chemical probe that will allow them study the receptor more precisely.
Researchers at the University of North Carolina at Chapel Hill have received a three-year, $1.8 million grant from the National Institutes of Health to develop a new implantable drug delivery system for long-lasting HIV-prevention.
A new study by UNC School of Medicine researchers suggests that food scarcity and poor oral health are major risk factors for malnutrition that leads an older adult – already at high risk of functional decline, decreased quality of life, and increased mortality – to land in the emergency department.
In a study published in the journal JAMA Oncology, UNC Lineberger Comprehensive Cancer Center researchers report that women diagnosed and treated for cancer during their childbearing years more commonly gave birth prematurely, and to babies whose weights were below normal ranges. Cancer survivors also had a slightly higher rate of cesarean section deliveries.
University of North Carolina scientists found that mucin proteins, which make mucus thick and sticky, fail to unfold properly in the airways of people with cystic fibrosis. And they found the lack of water in the lung can trigger the misfolding mucins.
A new study led by UNC Lineberger Comprehensive Cancer Center researchers identifies distinct patterns of side effects for prostate cancer treatments that patients could use to guide their choices.
In a study published in journal Nature Immunology, UNC Lineberger researchers describe how inflammation can go unchecked in the absence of a certain inflammation inhibitor called NLRP12. In a harmful feedback loop, this inflammation can upset the balance of bacteria living in the gut.
In an MRI study, researchers found that many toddlers diagnosed with autism at age 2 had a substantially greater amount of extra-axial cerebrospinal fluid (CSF) at six and 12 months of age, before diagnosis is possible. Researchers also linked increased severity of symptoms to increased CSF.
UNC scientists found that as mice learn to associate a particular sound with a rewarding sugary drink, one set of prefrontal neurons becomes more active and promotes reward-seeking behavior while other prefrontal neurons are silenced, and those neurons act like a brake on reward-seeking.
UNC Lineberger researchers and colleagues report in the journal Clinical Cancer Research that a measure of muscle mass and muscle quality developed at UNC could potentially help doctors better identify patients at high risk for toxic side effects that could require hospitalizations.
The UNC AARP Sprint aims to find digital health solutions to the challenge of: How can wearables be used to seamlessly galvanize the 50+ population to take the right medications as prescribed?
Scientists have struggled to trace the specific biology behind diabetes-associated heart disease risk or find ways to intervene. Now, UNC researchers have hunted down a possible culprit – a protein called IRS-1, which is crucial for the smooth muscle cells that make up veins and arteries.
A UNC-Chapel Hill researcher has published a study in Lancet Oncology online that identifies sentinel-lymph-node mapping as a safer and less-invasive method of staging endometrial cancer that is equally as accurate as the more traditional lymphadenectomy.
Using magnetic resonance imaging (MRI) in infants with older siblings with autism, researchers from around the country were able to correctly predict 80 percent of those infants who would later meet criteria for autism at two years of age.
Day in and day out, the DNA in our cells is damaged for a variety of reasons, and thus DNA-repair systems are fundamental to the maintenance of life. Now UNC scientists have confirmed and clarified key molecular details of one of these repair systems, known as nucleotide excision repair.
Researchers at the UNC School of Medicine believe they have isolated a protein that, when missing or depleted, can cause airway constriction, production of mucus, chest tightness, and difficulty breathing for the 334 million people worldwide who suffer from asthma.
UNC Medical Center is the first in the Mid Atlantic U.S. to treat patients with the EnSite Precision™ cardiac mapping system, a next-generation platform designed to provide automation, flexibility and accuracy for diagnostic mapping used in ablation procedures to treat patients with abnormal heart rhythms (cardiac arrhythmias). UNC Medical Center was among the first sites in the United States to utilize this technology, which recently received FDA clearance.
The ancient impulse to procreate is necessary for survival and must be hardwired into our brains. Now scientists from the University of North Carolina School of Medicine have discovered an important clue about the neurons involved in that wiring.
UNC School of Medicine researchers crystalized the structure of LSD attached to a human serotonin receptor of a brain cell, and they may have discovered why an “acid trip” lasts so long.
After surgery to remove a cancerous tumor – even if the surgery is considered “successful” – it’s nearly impossible to ensure that all microtumors have been removed from the surgical site. Cancer recurrence is always a major concern. Meanwhile, tiny blood cells called platelets rush in to start the post-surgical healing process. What if those platelets could carry anti-cancer drugs to wipe out those microtumors? UNC and NC State scientists have developed a way to do just that, and they have shown success in animal studies, published today in Nature Biomedical Engineering.
The UNC School of Medicine has awarded the 17th Perl-UNC Neuroscience Prize to David Anderson, PhD, the Seymour Benzer Professor of Biology at the California Institute of Technology for “his discovery of neural circuit mechanisms controlling emotional behaviors.”
Unmasking a previously misunderstood gene, Gpr182, University of North Carolina scientists discover an unlikely potential drug target for gastrointestinal cancers.
In the late 1990s, the World Health Organization (WHO) issued a policy requiring the establishment of centralized blood banking facilities in Sub-Saharan African countries. Anthony Charles, MD, MPH, associate professor of surgery at the UNC School of Medicine, says that this policy is now having unintended negative consequences.
In the journal Cancer Discovery, UNC Lineberger Comprehensive Cancer Center researchers and colleagues report findings of how triple negative breast cancer cells are able to bypass treatment with trametinib, a U.S. Food and Drug Administration-approved drug that belongs to a class of commonly used anti-cancer drugs called kinase inhibitors. The researchers also reported findings from laboratory models of breast cancer testing a potential treatment approach that could prevent the onset of resistance.
A national consortium of clinical geneticists is studying the ins and outs of potentially using genome sequencing for newborn health screenings and beyond.
In a perspective published in the New England Journal of Medicine, a UNC Lineberger Comprehensive Cancer Center researcher addresses the need for – and the barriers preventing – electronic reporting of patients’ symptoms between visits.
A research team at the UNC School of Medicine found that the Graduate Record Exam (GRE), which is required for admission to graduate and doctorate programs across the country, is not the best indicator for predicting a student’s success while pursuing a doctorate in the experimental life sciences. And from that research, the team recommends devaluing – if not eliminating altogether – the GRE from the applications process for biomedical PhD candidates.
UNC scientists found more clues about the evolving brains of baby mammals as eyesight comes online. Using an imaging system to get neuron-level resolution, they showed how one specific brain circuit in mice came online immediately after birth, but another needed visual stimuli in order to mature.
Researchers have found iron deficiency anemia protects children against the blood-stage of Plasmodium falciparum malaria in Africa, and treating anemia with iron supplementation removes this protective effect.
Scientists at the University of North Carolina School of Medicine have developed a method to control proteins inside live cells with the flick of a switch, giving researchers an unprecedented tool for pinpointing the causes of disease using the simplest of tools: light.
Scientists have few good methods for manipulating and investigating G-protein signaling. Now, UNC scientists have developed small proteins to selectively block a certain type of G-protein signaling, creating a unique and powerful tool for studying cell processes that depend on this signaling.
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