The clinically approved AIDS drug ABC (Abacavir) can reduce proliferation and induce differentiation of human medulloblastoma cells through the downregulation of telomerase activity, which may make it an effective therapeutic strategy for the treatment of the highly malignant primary brain tumors, according to research published in the International Journal of Cancer.
Researchers have tagged two new potential targets for treating rhabdomyosarcoma (RMS) -- a highly malignant pediatric tumor thought to arise from mesenchymal stem cells (MSCs) committed to become skeletal muscle cells.
A single tumor-suppressor gene may provide a unique marker for senescence in Mesenchymal stem cells (MSCs) in vitro, while also playing a role in moving MSCs into senescence, researchers at the Human Health Foundation and the Sbarro Institute for Cancer Research and Molecular Medicine report.
The tumor suppressor gene pRb2/p130 may provide the first independent prognostic biomarker in cases of soft tissue sarcoma (STS), according to an international collaboration of researchers.
The role played by the protein cdk9-55 in muscle regeneration and differentiation may lead to new therapies to rebuild muscle tissue damaged by disease, injury, and aging, according to researchers at the Sbarro Institute for Cancer Research and Molecular Medicine at Temple University in Philadelphia and at the University of Siena, Italy.
Professor Claudio Napoli, a Full Professor at the II University of Naples and Adjunct Professor at the Sbarro Research Institute for Cancer Research and Molecular Medicine in the College of Science and Technology of Temple University, is part of a multicenter team presenting a novel strategy for circumventing safety problems that have plagued gene therapy.
Sbarro Health Research Organization will be one of the first groups to use Virtual Lab on the futuristic world of Second Life. The Lab will one day help train young scientists in research procedures and protocols with state of the art lab equipment.
Scientists have known that it takes combinations of chromatin remodeling factors to keep the processes of self-renewal, proliferation and differentiation of stem cells in proper balance. Now, researchers have discovered that forced expression of chromatin remodeling factor Brg1 induces cell cycle arrest, death and deterioration in mesenchymal stem cells (MSCs), upsetting this delicate harmony.
Laszlo Otvos, Jr.,MD, research professor and director of Drug Development for Sbarro Institute of Cancer Research and Molecular Medicine, is recognized for writing a "Most Cited: 2006" paper according to ACS Publications.
Roche Diagnostics and Sbarro Health Research Organization link to provide enhanced bio-medical research.
The Human Health Foundation (HHF), a nonprofit organization designed to develop and fund biomedical research in Italy will be introduced on July 15th during this year's annual Spoleto Festival by Antonio Giordano, MD, PhD, president and founder of the Sbarro Health Research Organization (www.shro.org).
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