Scientists at The Scripps Research Institute have integrated biomedical data into Wikidata, a public, editable database where researchers can easily link genes, proteins and more.
Scientists from the Florida campus of The Scripps Research Institute have identified a unique memory suppressor gene in the brain cells of Drosophila, the common fruit fly, a widely recognized substitute for human memory studies.
Scientists at The Scripps Research Institute (TSRI) and collaborating institutions have described the first-ever immature or “teenage” antibody found in a powerful class of immune molecules effective against HIV.
A new study led by scientists at The Scripps Research Institute reveals a previously unknown type of immune cell. The discovery opens new avenues in the effort to develop novel therapies for autoimmune diseases such as type 1 diabetes.
A team from the Florida campus of The Scripps Research Institute (TSRI) and the University of North Carolina (UNC) has been awarded $3.4 million from the National Institute on Drug Abuse of the National Institutes of Health (NIH) to develop novel therapeutics for the treatment of addiction and mood disorders.
In a new study, researchers at The Scripps Research Institute report that, based on its structure, a hollowed-out version of the cowpea mosaic virus, a plant pathogen that can be modified to aid in tumor detection and chemotherapy, could also be effective in human therapies.
A team led by scientists at The Scripps Research Institute and the Salk Institute for Biological Studies has discovered two enzymes that appear to play a role in metabolism and inflammation—and might someday be targeted with drugs to treat type 2 diabetes and inflammatory disorders.
In a landmark feat of chemical synthesis, scientists at The Scripps Research Institute have developed a 19-step process for making the naturally occurring compound phorbol in the laboratory, in quantities that are useful for pharmaceutical research.
Scientists from the Florida campus of The Scripps Research Institute have received a $1.4 million grant from the Department of Defense to develop a series of drug candidates that act against molecules closely linked with the growth of cancer cells.
A study led by scientists at The Scripps Research Institute (TSRI) shows that genome-wide molecular profiling of kidney biopsies may be a key to catching organ rejection before it’s too late.
A new study led by scientists at The Scripps Research Institute suggests that cells construct protein “clumps” to protect against neurodegenerative diseases such as amyotrophic lateral sclerosis, a.k.a. ALS or Lou Gehrig’s disease.
A new study by scientists from the Florida campus of The Scripps Research Institute has identified specific genetic variations closely associated with increased susceptibility to bipolar disorder and other conditions. The discovery may provide a target for new therapies.
Scientists from the Florida campus of The Scripps Research Institute have been awarded $2.4 million from the National Institutes of Health to identify the brain circuits involved in weight control and to develop novel strategies to fight obsessive eating and obesity.
Using a new approach, scientists at The Scripps Research Institute and collaborating institutions have discovered a novel drug candidate that could be used to treat certain types of breast cancer, lung cancer and melanoma.
In a new study published today in the journal Neuron, scientists from The Scripps Research Institute (TSRI) are the first to sequence the complete genomes of individual neurons and to produce live mice carrying neuronal genomes in all of their cells.
A new study from scientists at The Scripps Research Institute describes the high-resolution structure of the HIV protein responsible for recognition and infection of host cells. The studyis the first to show this HIV protein, known as the envelope (Env) trimer, in its natural or “native” form.
A team has solved the structure of a key protein in HKU1, a coronavirus identified in Hong Kong in 2005 and highly related to SARS and MERS. They believe their findings will guide future treatments for this family of viruses.
Cutting-edge science, a host of exciting interactive displays, plus dozens of Scripps Florida scientists will be on hand at the Gardens Mall on Saturday, March 5, 2016, from 10:00 a.m. to 3:00 p.m. for the seventh annual CELLebrate Scripps Florida Science Day.
Scientists from the Florida campus of The Scripps Research Institute have for the first time developed a way to predict how a specific type of stem cell will act against different diseases.
Scientists from The Scripps Research Institute have identified a molecule that appears to be a cause of autoimmune diseases such as lupus. Elevated levels of the molecule allow self-reactive immune cells to escape into the blood stream and attack the body’s own tissues.
A research team that included scientists from The Scripps Research Institute has identified a new group of powerful antibodies to fight Ebola virus. The antibodies could guide the development of a vaccine or therapeutic against Ebola.
A new study led by scientists at The Scripps Research Institute (TSRI) and the J. Craig Venter Institute (JCVI) shows that the act of creating pluripotent stem cells for clinical use is unlikely to pass on cancer-causing mutations to patients.
Courtney Miller, associate professor on the Florida campus of The Scripps Research Institute (TSRI), has been selected to receive a Presidential Early Career Award for Scientists and Engineers, the highest honor bestowed by the United States government on young professionals at the outset of their independent research careers.
With use of synthetic opioid “designer drugs” rising, scientists from The Scripps Research Institute have a new strategy to curb addiction and even prevent fatal overdoses, reporting successful preclinical tests of a vaccine that prevents the synthetic opioid fentanyl from reaching the brain.
Scientists from the Florida campus of The Scripps Research Institute have won nearly $1.7 million from the National Institutes of Health’s National Institute of Neurological Disorders and Stroke to investigate the mechanisms that contribute to Huntington’s disease.
In a new study, scientists from the Florida campus of The Scripps Research Institute, working in collaboration with scientists from the University of California, Irvine, show that a specific microRNA has strong links to a number of neuropsychiatric disorders, including autism spectrum disorder
A new study in animal models, led by scientists at The Scripps Research Institute, is the first to show that oxygen sensing in the brain has a role in metabolism and sensing an organism’s internal state.
Scientists at the Florida campus of The Scripps Research Institute have developed a device that can do the functional equivalent of high-throughput compound screening on an ultra-miniaturized scale.
Scientists from The Scripps Research Institute Florida campus have been awarded nearly $1.2 million from the National Institutes of Health to create a series of drug candidates that advance treatments for such conditions as obesity, type-2 diabetes, cardiovascular disease and muscle atrophy.
The co-developer of Remicade®, one of the three top-selling drugs in the world, has donated more than $500,000 to fund what will be known as the Iris and Junming Le Foundation Super-Resolution Microscopy Facility on the Florida campus of The Scripps Research Institute (TSRI).
Solving a long-standing mystery in cell biology, a team has shown how a key “relief-valve” in cells keeps cells from taking in too much water and swelling excessively. The mechanism has been linked to stroke-induced brain damage, diabetes, immune deficiency and cancer treatment resistance.
Philanthropist and businessman Samuel Yin of Taiwan has given $12.8 million to The Scripps Research Institute to help fund construction of a new building complex on the La Jolla campus.
A new study led by scientists at The Scripps Research Institute (TSRI) and the University of California (UC), Berkeley shows how a crucial molecular enzyme starts in a tucked-in somersault position and flips out when it encounters the right target. The new findings give scientists a clearer picture of the process through which cells eliminate proteins that promote diseases such as cancer and Alzheimer’s.
A new study led by scientists at The Scripps Research Institute shows how dangerous autoimmune responses, seen in diseases such as lupus and multiple sclerosis, might be “dialed down” without compromising the immune system’s ability to fight viruses and bacteria.
Chemists at The Scripps Research Institute (TSRI) have devised a new and widely applicable technique for building potential drug molecules and other organic compounds.
Chemists at The Scripps Research Institute have developed a versatile new technique for making modifications—especially one type of extremely difficult, but much-sought-after modification—to complex drug molecules.
Scientists at The Scripps Research Institute have discovered that a lipid (fat molecule) in brain cells may act as a “switch” to increase or decrease the motivation to consume nicotine.
Scientists at The Scripps Research Institute have received a grant of more than $2.1 million from the National Institutes of Health’s National Institute of General Medical Sciences to create and screen a new library of drug candidates, using a branch of click chemistry.
A new study led by scientists at The Scripps Research Institute and St. Jude Children’s Research Hospital shows how a protein involved in cancer twists and morphs into different structures.
Findings from a new study led by scientists from the Florida campus of The Scripps Research Institute suggest a potent new therapeutic approach for a number of hard-to-treat breast cancers.
A scientist from the Florida campus of The Scripps Research Institute has been awarded approximately $2 million from the National Institutes of Health to study the impact of aging and age-related disease on the inner workings of a single type of nerve cell.
In a new study, a team led by scientists at The Scripps Research Institute tracked how a family of these HIV-fighting antibodies develops over time. The research shows how a future vaccine might trigger the immune system to produce these antibodies more effectively.
A new study, led by scientists at The Scripps Research Institute, shows how different pharmaceutical drugs hit either the “on” or “off” switch of a signaling protein linked to asthma, obesity and type 2 diabetes.
Scientists from The Scripps Research Institute have deployed a powerful new drug discovery technique to identify an anti-diabetes compound with a novel mechanism of action, a technique with significant potential to quickly find drug candidates.
For the first time, scientists from the Florida campus of The Scripps Research Institute have created detailed “fingerprints” of a class of surface receptors that have proven highly useful for drug development.
With the support of a $2.8 million NIH grant, scientists at The Scripps Research Institute will explore mutations in the nuclear lamina—the outer edge of the cell nucleus— which have been linked to many diseases, from muscular dystrophies and heart disorders to type 2 diabetes and premature aging.
Scientists at The Scripps Research Institute (TSRI) have found evidence that a mutant protein responsible for most cases of cystic fibrosis is so busy “talking” to the wrong cellular neighbors that it cannot function normally and is prematurely degraded.
Scientists from the Florida campus of The Scripps Research Institute (TSRI) have shown for the first time how a previously unknown process works to promote infection in a number of dangerous viruses, including dengue, West Nile and Ebola.
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