Anti-HIV medications suppress the viral load of people living with HIV and provide durable protection against heterosexual transmission a study led by the University of North Carolina at Chapel Hill found. Researchers found a 93 percent reduction of HIV transmission when the HIV-infected person started antiretroviral therapy or ART at a higher CD4 cell count.
Nigel Key, MB, ChB, FRCP, director of the UNC Hemophilia and Thrombosis Center, is lead author of an advisory opinion on research priorities to address VTE in cancer patients.
Researchers at the University of North Carolina at Chapel Hill will receive nearly $23 million over the next five years to continue research on their innovative “kick and kill” strategy for eradicating HIV.
UNC Health Care and the UNC School of Medicine have launched a tool for media to request interviews with experts and researchers at the forefront of the global Zika research initiative.
Researchers point out in a commentary published in today’s Annals of Family Medicine that existing treatments are more effective than e-cigarettes to help people quit smoking, there are professional ethics concerns about providers who recommend them, and there is no strong evidence that e-cigarettes are safe.
Researchers found that the rate of a certain chemical change in DNA – a key driver of spontaneous mutation and thus of evolution’s pace – increases rapidly with temperature. The scientists concluded that the rate of spontaneous mutation was at least 4,000 times higher than it is today.
For patients treated in a hospital, the risk of death from acute myeloid leukemia was elevated in three regions of North Carolina compared to a benchmark.
A study by UNC Lineberger Comprehensive Cancer Center researchers has revealed the genetic mechanism for how acute myeloid leukemia cells with a specific DNA mutation stay as undifferentiated cells.
CHAPEL HILL, NC — With no laboratory test available to diagnose functional gastrointestinal disorders, proper diagnostic criteria are critical for clinicians to make an accurate determination of what ails their patients. Several University of North Carolina School of Medicine researchers played a key role in crafting diagnostic criteria and patient questionnaires for the Rome Foundation, an international nonprofit aimed at improving the lives of the millions of people suffering from functional GI disorders (FGIDs), while developing and legitimizing the field of FGIDs through science and research.
A University of North Carolina School of Medicine scientist has been awarded an inaugural global award from Science and Science Translational Medicine and Boyalife for her research in healing damaged heart muscle.
Smoking cigarettes alters dozens of genes important for immune defense in epithelial cells in the respiratory tract. These changes likely increase the risk of bacterial infections, viruses, and inflammation. Now, scientists report that e-cigarette use alters hundreds of genes.
According to data from the large, multinational LEADER clinical trial, the glucose-lowering drug liraglutide safely and effectively decreases the overall risk of heart attack, stroke, or cardiovascular death, kidney disease, and death from all causes for people with type 2 diabetes.
A national health claims analysis of cancer patients who were younger than age 65 and had metastatic disease revealed that nearly two-thirds were admitted to the hospital or visited the emergency room in the last 30 days of their lives. The researchers said nearly a third of patients died in the hospital.
In a preliminary finding (abstract 5568) presented Monday, June 6, at the 2016 American Society of Clinical Oncology Annual Meeting in Chicago, researchers revealed they have found bacteria in the upper female reproductive tract.
Researchers report preliminary findings at the American Society of Clinical Oncology Annual Meeting 2016 that 26 percent of a survey of adult cancer patients reported they paid more for medical care than they could afford. Those patients also reported missing appointments and prescriptions because of affordability issues.
Researchers from the University of North Carolina at Chapel Hill and East Carolina University report in the American Journal of Preventive Medicine that in all nine regions of the country, a majority of adults supported increasing the minimum legal age for tobacco product sales.
In the journal npj Breast Cancer, researchers reported they identified a particular gene expression pattern in normal-appearing breast tissue around tumors that was linked to lower 10-year survival rates for women with estrogen receptor-positive breast cancer.
In the journal The Oncologist, researchers report that the median survival for a group of Medicare patients on the drug sorafenib was three months, which was significantly lower than the median survival of nearly 11 months for patients treated with the drug during a phase III clinical trial.
UNC School of Medicine scientists create SEWING, a technique inspired by natural evolutionary mechanisms to recombine portions of known proteins to produce new structures with the distinctive features that proteins require to carry out specific biological functions.
Rebecca S. Williams, a researcher with the University of North Carolina Lineberger Comprehensive Cancer Center and a leading expert in the study of Internet tobacco sales, including e-cigarettes, applauds the FDA’s ruling.
Compound found to be highly active against cancer driven by EZH2 mutation in laboratory models
An analysis by a University of North Carolina at Chapel Hill researcher reports in JAMA Oncology that a month of treatment with orally-administered cancer drugs introduced in 2014 were, on average, six times more expensive at launch than cancer drugs introduced in 2000 after adjusting for medical inflation. Drugs approved in 2000 cost an average of $1,869 per month compared to $11,325 for those approved in 2014.
Satish Gopal, MD, MPH, a UNC Lineberger Comprehensive Cancer Center member, has called for a commitment to contribute resources and energy to control cancer in less-resourced countries n a perspective published in the April 28 issue of the New England Journal of Medicine.
A study by researchers from the University of North Carolina Lineberger Comprehensive Cancer Center and other institutions found a link between higher intake of dietary saturated fat, a type of fat found commonly in foods such as fatty beef and cheese, and risk of aggressive prostate cancer.
Scientists at the University of North Carolina School of Medicine have developed a way to embed light-responsive switches into proteins so that researchers can use lasers to manipulate protein movement and activity within living cells and animals.
A UNC Lineberger Comprehensive Cancer Center-led study has found that women who have had a false-positive mammogram result are more or less likely to get screened at recommended intervals depending on the timing of their last screen.
New research of old data suggests that using vegetable oils high in linoleic acid failed to reduce heart disease and overall mortality even though the intervention reduced cholesterol levels. And consuming vegetable oils might actually be worse than eating butter.
Study raises concerns about access to proven, yet expensive, drug therapy for HER2 subtype
Scientists at the UNC School of Medicine have found a class of commonly used fungicides that produce gene expression changes similar to those in people with autism and neurodegenerative conditions, including Alzheimer’s disease and Huntington’s disease.
Researchers with the UNC Lineberger Comprehensive Cancer Center examined whether weight loss via four different diets was linked to reduced tumor growth in laboratory models of breast cancer. Their preliminary findings will be presented tat the 2016 American Association for Cancer Research Annual Meeting in New Orleans.
Weight loss surgery was more effective than a low-fat diet at reversing the cancer-promoting effects of chronic obesity in mice, according to a study led by UNC Lineberger Comprehensive Cancer Center researchers. The preliminary findings will be presented at the 2016 American Association of Cancer Research Annual Meeting in New Orleans.
A University of North Carolina Lineberger Comprehensive Cancer Center-led study has identified genetic differences in tumors of African-Americans with the most common type of kidney cancer compared with whites.
This study has helped determine that UBE3A gene loss specifically from GABAergic neurons is what’s critical for seizures in Angelman patients. But UBE3A loss from other neuron types may drive other phenotypes associated with the condition.
In an effort to minimize obstacles to adherence and prevent vaginal HIV transmission, UNC researchers and collaborators from Merck demonstrated the effectiveness of a new long-acting formulation of the HIV drug raltegravir in animal models.
Researchers at UNC Lineberger Comprehensive Cancer Center, UNC Eshelman School of Pharmacy, the Aflac Cancer & Blood Disorders Center in Atlanta, Emory University School of Medicine, and at other institutions report that a novel compound MRX-2843 more than doubled the median days of survival in laboratory models with a drug-resistant form of the acute myeloid leukemia.
UNC researchers uncovered a cellular mechanism by which kappa opioid receptors drive anxiety. These proteins inhibit the release of the neurotransmitter glutamate in a part of the brain that regulates emotion. KORs are targets for the treatment of addiction and anxiety disorders.
For decades, researchers have tried to duplicate the function of beta cells, which don’t work properly in patients with diabetes. Now, researchers have devised another option: a synthetic patch filled with natural beta cells that can secrete doses of insulin to control blood sugar levels on demand.
In the journal Cell Reports, UNC Lineberger researchers reported they found markedly low levels of the protein NLRX1 in multiple laboratory models of colorectal cancer, and in samples of human tissue. Studies have shown that the protein is known to be involved in regulating immune system signals in order to prevent hyperactive inflammatory responses by the immune system, but UNC Lineberger researchers believe their finding also points to a role for the protein in preventing colorectal cancer growth. Based on their findings, they believe they’ve identified a potential treatment for colorectal cancer with low NLRX1.
Patients with heart failure often have a buildup of scar tissue that leads to a gradual loss of heart function. In a new study, UNC researchers report significant progress toward a novel approach that could shrink the amount of heart scar tissue while replenishing the supply of healthy heart muscle.
Research led by UNC’s John Buse showed that IDegLira injections were more effective than basal insulin glargine injections at reducing the average amount of blood sugar over the course of several months. IDegLira was also associated with weight loss and a substantially lower rate of hypoglycemia.
In a first-of-its-kind-study, researchers at the University of North Carolina Lineberger Comprehensive Cancer Center discovered and applied a new screening technique capable of testing thousands of potential drug compounds to see if those compounds can reverse abnormal DNA unwinding in Ewing sarcoma, a bone and soft tissue cancer that’s most common in teens and young adults.
Copies of the mouse gene R2d2 can spread quickly through lab and wild mouse populations, despite the fact that the genes cause females to have fewer offspring. This is the first time scientists have used mice to show that a selfish gene responsible for infertility can become fixed in a population.
Preliminary findings from a study examining the genetic alterations in HPV-positive oropharyngeal squamous cell carcinoma were presented Thursday at the 2016 Multidisciplinary Head and Neck Cancer Symposium. The researchers found differences in the genetic mutations of HPV-positive oropharyngeal cancer based on whether patients were heavy versus light smokers.
A UNC Lineberger researcher was first-author of a report published in the Journal of Clinical Oncology that details guidelines for the active surveillance of men with low-risk prostate cancer. The guidelines, originally authored by Cancer Care Ontario, were reviewed and endorsed by the American Society of Clinical Oncology with some revisions.
UNC School of Medicine scientists studying one of the world’s most virulent pathogens and a separate very common bacterium have discovered a new way that some bacteria can spread rapidly throughout the body – by hitchhiking on our own immune cells.
Ilona Jaspers, PhD, from the UNC School of Medicine, recently completed research showing how the chemicals in e-cigarettes can change immune responses in our airways. She will present her findings at the AAAS annual meeting February 11-16.
Implantable device delivers first-line treatment for pancreatic cancer directly to tumors, bypassing bloodstream and limiting widespread side effects.
For the first time, investigators in the Division of Infectious Diseases at the University of North Carolina School of Medicine have determined how antiretroviral therapy (ART) affects the way HIV disseminates and establishes infection in the female reproductive tract. These observations have significant implications for future HIV prevention, vaccine and cure studies.
Mutations in the gene TBX5 have been shown to cause both rare and more prevalent forms of congenital heart disease, yet the underlying mechanisms have remained unclear. A team led by researchers at the University of North Carolina at Chapel Hill has now found evidence pointing to a culprit.
Harvard's Christopher Walsh wins the 16th Perl UNC Neuroscience Prize for the "discovery of genes and mechanisms regulating human cortical development" from the University of North Carolina School of Medicine.
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