Low Estrogen in Menopause Reduces Expression of Bone Mass-regulating Protein, May Lead to Bone Loss

Article title: "Inhibition of osteoclastogenesis by mechanically stimulated osteoblasts is attenuated during estrogen deficiency"

Authors: Hollie Allison and Laoise M. McNamara

From the authors: "In this study, we report for the first time that under combined mechanical loading and postmenopausal conditions, stimulated by either the withdrawal of estrogen or inhibiting the estrogen receptor, a significant increase in osteoblast-induced osteoclast differentiation and matrix degradation occurs." 

This study is highlighted as one of October’s “best of the best” as part of the American Physiological Society’s APSselect program.