The COVID-19 pandemic resulted in social distancing limitations not previously experienced, forcing practitioners to adapt exercise programming to a virtual model. The purpose of this investigation was to measure the effectiveness of a virtual exercise oncology program in 491 participants undergoing antineoplastic therapy between March and June 2020. Each session was completed virtually with a certified exercise oncology trainer. Fitness and psychological parameters were measured pre-exercise and postexercise intervention. Overall, participants completed 4,949 of 5,892 prescribed exercise sessions. Patients saw increases in cardiovascular endurance, muscular endurance, flexibility, feelings of support and quality of life, as well as decreases in loneliness and fatigue.