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  • Researchers from Georgia Tech and Emory University have developed a new type of biomolecular tweezers that could help researchers study how mechanical forces affect the biochemical activity of cells and proteins.
    Image courtesy of Lizhi Cao
    Researchers from Georgia Tech and Emory University have developed a new type of biomolecular tweezers that could help researchers study how mechanical forces affect the biochemical activity of cells and proteins.
  • Schematic A shows the chip layout, with circular nickel pads (blue), which can be magnetized by an external magnet flanked by interdigitated gold electrodes (red). Schematic B shows paramagnetic beads introduced to the chip surface by microfluidics and loaded onto the magnetic pads by magnetic manipulation, facilitating the formation of bead surface tethers via antibody-antigen interactions. Schematic C shows interactions probed by application of sufficient nDEP force to displace non-specifically bound beads, but not specifically bound beads. Schematic D shows how the devices are fabricated.
    Image courtesy of Lizhi Cao
    Schematic A shows the chip layout, with circular nickel pads (blue), which can be magnetized by an external magnet flanked by interdigitated gold electrodes (red). Schematic B shows paramagnetic beads introduced to the chip surface by microfluidics and loaded onto the magnetic pads by magnetic manipulation, facilitating the formation of bead surface tethers via antibody-antigen interactions. Schematic C shows interactions probed by application of sufficient nDEP force to displace non-specifically bound beads, but not specifically bound beads. Schematic D shows how the devices are fabricated.
  • Researchers (l-r) Thomas Barker, Lizhi Cao and Wilbur Lam are shown in the Marcus Nanotechnology Building, where the molecular tweezers are fabricated in clean rooms.
    Georgia Tech Photo: Rob Felt
    Researchers (l-r) Thomas Barker, Lizhi Cao and Wilbur Lam are shown in the Marcus Nanotechnology Building, where the molecular tweezers are fabricated in clean rooms.
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