Change in tubulin collective dipole modes due to the addition of anesthetic and non-anesthetic molecules, with maximum agent-induced change in tubulin normal-mode oscillation frequency at (613 ± 8) THz plotted versus each molecule’s minimum alveolar concentration (MAC). Blue:Anesthetic, Green;Anesthetic/convulsant, Pink:Non-anesthetic, - Meth:Methoxyflurane, Halo:Halothane, Iso:Isoflurane, En:Enflurane, DEth: Diethyl ether, Sevo:Sevoflurane, Flur:Flurothyl, Des:Desflurane, Nitr:Nitrous oxide, F6:dichlorohexafluorocyclobutane, TFMB: trifluoromethylbenzene). For anesthetic and non-anesthetic molecules, alterations in oscillation frequency correlate closely with their anesthetic potency (1/MAC). Non-anesthetics (shown with MAC of 1000%, 10 atmospheres) are predicted with their correct lack of potency, unlike with the Meyer-Overton correlation. Reproduced from Craddock et al., Sci. Rep., 2017.