Detailed Structure Illuminates Brain-Enhancing Drug’s Action

Credit: J. Tsai et al./Science 2018

This 3-D rendering shows the propeller-shaped molecule ISRIB (red and white) tucked into the center of eIF2B, stapling two halves of the protein complex together.

« Detailed Structure Illuminates Brain-Enhancing Drug’s Action

Credit: J. Tsai et al./Science 2018

Using cryo-electron microscopy, researchers have revealed atomic-level details of the interactions between a brain-boosting experimental drug (propeller-shaped molecule, center) and its target protein, eIF2B.

« Detailed Structure Illuminates Brain-Enhancing Drug’s Action

Credit: Walter Lab/ HHMI/ UCSF

In this 3-D printed model, the eIF2B protein's subunits are printed in different colors.

« Detailed Structure Illuminates Brain-Enhancing Drug’s Action

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