Brookhaven National Laboratory
The scientists investigated the chemical structures of 16 drugs based on the same tetrahydroquinoline (THQ) scaffold. On the left is a cartoon of the BRD4 protein bound to one of these drugs; on the right is a molecular representation of a drug with the THQ scaffold highlighted in magenta. Regions that are chemically modified between the drugs investigated in this study are labeled 1 to 4. Typically, only a small change is made to the chemical structure of one drug to the next. This conservative approach makes it easier for researchers to understand why one drug is effective, whereas another is not.