Credit: Frontiers in Energy Research
Different networks representing biological relationships are integrated and used to provide multiple lines of evidence (LOE) to discover genes that can be manipulated to enhance biofuels and bioproducts. The illustration shows how it works. High-resolution genomic data combined with co-expression datasets are used to build networks and then the networks are layered. Specific genes (orange) are identified, and a LOE score is calculated for each one (an example of the LOE score calculation is shown) that can be used to determine a set of potential target genes.