Graphs show performance in an Object Location Memory task in which mice were tested for recognition of an object that was moved to a novel location. Left graph shows that, given 5 minutes of training, prepubescent females perform well on the task whereas adult females do not learn. In males the opposite pattern is observed: prepubescent males fail to learn whereas learning is robust in adults. Right graph shows that treatment of adult females with the negative α5 GABAA receptor modulator (L655,708) restores learning to levels seen before puberty.