A new study from Washington University School of Medicine in St. Louis has revealed the details of two key transition points in the development of pancreatic cancer. The study provides insights into treatment resistance and how immunotherapy could be harnessed to treat this aggressive tumor type. Shown is a human pancreatic tumor. Cell nuclei are in blue; cell membranes are in red; proliferating cell nuclei are in cyan. Other colors highlight different kinds of immune cells and cells of connective tissue.