Mesenchymal stem cell-derived exosomes: A novel and potential remedy for cutaneous wound healing and regeneration

Poor healing of cutaneous wounds is a common medical problem in the field of traumatology. Due to the intricate pathophysiological processes of wound healing, the use of conventional treatment methods, such as chemical molecule drugs and traditional dressings, have been unable to achieve satisfactory outcomes. Within recent years, explicit evidence suggests that mesenchymal stem cells (MSCs) have great therapeutic potentials on skin wound healing and regeneration. However, the direct application of MSCs still faces many challenges and difficulties. Intriguingly, exosomes as cell-secreted granular vesicles with a lipid bilayer membrane structure and containing specific components from the source cells may emerge to be excellent substitutes for MSCs. Exosomes derived from MSCs (MSC-exosomes) have been demonstrated to be beneficial for cutaneous wound healing and accelerate the process through a variety of mechanisms. These mechanisms include alleviating inflammation, promoting vascularization, and promoting proliferation and migration of epithelial cells and fibroblasts. Therefore, the application of MSC-exosomes may be a promising alternative to cell therapy in the treatment of cutaneous wounds and could promote wound healing through multiple mechanisms simultaneously. This review will provide an overview of the role and the mechanisms of MSC-derived exosomes in cutaneous wound healing, and elaborate the potentials and future perspectives of MSC-exosomes application in clinical practice.

Key Words: Mesenchymal stem cells, Extracellular vesicles, Exosomes, Wound healing, Skin regeneration

Core Tip: The promotion of wound healing is an important obstacle in the treatment of trauma in clinic. Exosomes derived from mesenchymal stem cells (MSCs) may provide a novel remedy with advantages and prospects. Herein, we discuss the role and the underlying mechanisms via which MSC-derived exosomes improve cutaneous wound healing, and elaborate the potentials and future perspectives of MSC-exosome application in clinical practice.

• Citation: Hu JC, Zheng CX, Sui BD, Liu WJ, Jin Y. Mesenchymal stem cell-derived exosomes: A novel and potential remedy for cutaneous wound healing and regeneration. World J Stem Cells 2022; 14(5): 318-329
• URL: https://www.wjgnet.com/1948-0210/full/v14/i5/318.htm
• DOI: https://dx.doi.org/10.4252/wjsc.v14.i5.318