Newswise — Winner of the Stewart B. Dunsker, MD, Award, Ibrahim Hussain, MD, presented his research, Mesenchymal Stem Cell-seeded High-density Collagen Gel for Annular Repair: In Vivo Sheep Study, during the 2018 American Association of Neurological Surgeons (AANS) Annual Scientific Meeting.
The research group previously showed success with in vivo annulus fibrosus (AF) repair in rodents and sheep models using an acellular, riboflavin cross-linked, high-density collagen (HDC) gel. This current research reports on a study performed in sheep, analyzing the effects of seeding allogenic mesenchymal stem cells (MSCs) into this HDC gel for annular repair.
MSC-seeded HDC gel treated IVDs demonstrated a statistically significant improvement in X-ray and MRI endpoints, including disc height index (DHI), Pfirrmann grade and T2-relaxation time (a surrogate for disc hydration), over other experimental groups. At the microscopic level, there was a trend for more annular and nucleus pulposus organization with MSC-seeded HDC than acellular HDC and negative controls. Similar analyses for 16 weeks post-injury are ongoing.
Author Block: Christoph Wipplinger; Stephen Sloan; Rodrigo Navarro-Ramirez; Eliana Kim; Micaella Zubkov; Gernot Lang; Lawrence Bonassar; Roger Hartl
Disclosure: The author reported no conflicts of interest.
Media Representatives: The 2018 AANS Annual Scientific Meeting website’s press section will include releases on highlighted scientific research, AANS officers and award winners, Neurosurgery Awareness Month and other relevant information about the 2018 program. Releases will be posted on the 2018 AANS Annual Scientific Meeting website. If you have interest in a topic related to neurosurgery or would like to interview a neurosurgeon — either onsite or via telephone — during the event, please contact Alice Kelsey, AANS associate executive director, via email at [email protected].
About the 2018 AANS Annual Scientific Meeting: Attended by neurosurgeons, neurosurgical residents, medical students, neuroscience nurses, clinical specialists, physician assistants, allied health professionals and other medical professionals, the AANS Annual Scientific Meeting is the largest gathering of neurosurgeons in the nation, with an emphasis on the field’s latest research and technological advances. The scientific presentations accepted for the 2018 event will represent cutting-edge examples of the incredible developments taking place within the field of neurosurgery. Find additional information about the 2018 AANS Annual Scientific Meeting and the meeting program here.
Founded in 1931 as the Harvey Cushing Society, the American Association of Neurological Surgeons (AANS) is a scientific and educational association with more than 11,000 members worldwide. The AANS is dedicated to advancing the specialty of neurological surgery in order to provide the highest quality of neurosurgical care to the public. Fellows of the AANS are board-certified by the American Board of Neurological Surgery, the Royal College of Physicians and Surgeons of Canada or the Mexican Council of Neurological Surgery, A.C. Neurosurgery is the medical specialty concerned with the prevention, diagnosis, treatment and rehabilitation of disorders that affect the spinal column, spinal cord, brain, nervous system and peripheral nerves.
For more information, visit www.AANS.org.
RSS