Nanoparticle Treatment Increases Antioxidant Availability, May Improve Kidney Injury Survival

Article title: Oral delivery of nanoparticle urolithin A normalizes cellular stress and improves survival in mouse model of cisplatin-induced AKI

Authors: Dianxiong Zou, Raghu Ganugula, Meenakshi Arora, Mary B. Nabity, David Sheikh-Hamad, M. N. V. Ravi Kumar

From the authors: “Our results demonstrate that chronic intermittent hypoxia induces a hitherto uncharacterized long-term facilitation of catecholamine secretion from neonatal rat chromaffin cells in response to repetitive hypoxia, simulating hypoxic episodes encountered during apnea of prematurity. The sustained catecholamine secretion might contribute to cardiovascular morbidities in infants with apnea of prematurity.”

This study is highlighted as one of November's "best of the best" as part of the American Physiological Society's APSselect program.