Newswise — BETHESDA, Maryland – A genetic mutation could be the cause of severe eczema, according to new research published June 19 in Nature Genetics by researchers at the Uniformed Services University of the Health Sciences (USU).  Researchers believe these new findings could influence new treatment strategies for the millions of individuals who struggle with this chronic condition.

Until now, patients with rare genetic mutations shown to cause severe allergic symptoms also suffer frequent infections and other severe immune system defects.  In this new study, sequencing the genes of eight patients with severe eczema from four different families revealed they had mutations in the CARD11 gene. Some of these patients had other accompanying health issues, like infections, but others did not. The researchers were then able to determine that mutations in this single gene could cause severe eczema even in the absence of other medical issues.

The team of researchers also sought to understand why these newly discovered CARD11 mutations contributes to severe eczema. They found that although each family had a distinct mutation affecting a different region of the CARD11 protein, each mutation disrupted its normal function in T cells – an essential type of white blood cell. Interestingly, they found that glutamine, an essential amino acid needed for normal immune cell functions, which patients can also take as a supplement, might help correct the cellular defects that likely contribute to severe eczema. 

“More than 15 million people suffer from severe eczema in the U.S. It can have a significant impact on their lives – it can even disqualify them from serving in the military,” according to the study’s co-senior author Dr. Andrew Snow, assistant professor in Pharmacology and Molecular Therapeutics at USU. “Our findings suggest that something as simple as glutamine supplementation could be beneficial to patients like this, with or without CARD11 mutations present.”

The study, “Germline hypomorphic CARD11 mutations in severe atopic disease,” was led by Dr. Snow in collaboration with researchers from the National Institute of Allergy and Infectious Diseases at the National Institute of Health (NIH) and other institutions.

Funding for the study was provided by grants from USU and the NIH.

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About USU

The Uniformed Services University of the Health Sciences, founded by an act of Congress in 1972, is the nation’s federal health sciences university and the academic heart of the Military Health System. USU students are primarily active duty uniformed officers in the Army, Navy, Air Force and Public Health Service who have received specialized education in tropical and infectious diseases, TBI and PTSD, disaster response and humanitarian assistance, global health, and acute trauma care.  A large percentage of the university’s more than 5,800 physician and 1,000 advanced practice nursing alumni are supporting operations around the world, offering their leadership and expertise.  USU also has graduate programs in biomedical sciences and public health, most open to civilian and military applicants, and oral biology, committed to excellence in research.  The University's research program covers a wide range of clinical and other topics important to both the military and public health.  For more information about USU and its programs, visit