Research Alert

Article title: Interferon-γ inhibits sirtuin 6 gene expression in intestinal epithelial cells through a microRNA-92b-dependent mechanism

Authors: Fangyi Liu, Xiao Wang, Hua Geng, Heng-Fu Bu, Peng Wang, Isabelle G. De Plaen, Hong Yang, Jiaming Qian, Xiao-Di Tan

From the authors: “Our study provides new insights into how inflammation affects Sirt6 levels and may reveal a novel therapeutic target—miR-92b—for rescuing Sirt6 expression in the inflamed gut.” 

This study is highlighted as one of April's "best of the best" as part of the American Physiological Society's APSselect program.