Research Alert

Article title: Interferon-γ inhibits sirtuin 6 gene expression in intestinal epithelial cells through a microRNA-92b-dependent mechanism

Authors: Fangyi Liu, Xiao Wang, Hua Geng, Heng-Fu Bu, Peng Wang, Isabelle G. De Plaen, Hong Yang, Jiaming Qian, Xiao-Di Tan

From the authors: “Our study provides new insights into how inflammation affects Sirt6 levels and may reveal a novel therapeutic target—miR-92b—for rescuing Sirt6 expression in the inflamed gut.” 

This study is highlighted as one of April's "best of the best" as part of the American Physiological Society's APSselect program.

Journal Link: American Journal of Physiology - Cell Physiology