Research Alert

Legislation aimed at reducing animal use and the prohibitive costs associated with toxicological safety testing in animals represent major challenges for the pharmaceutical, cosmetic, and agrochemical industries and their quest to bring new compounds to market. Our studies illustrate that a simple social amoeba (a.k.a., slime mold) represents a promising novel low-cost, non-animal model system that is predictive of mammalian toxicity and amenable to molecular genetic technology to understand the mechanisms underlying toxicity.

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Toxicological Sciences, Advance Access

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162812788617255_TOXSCI-21-0117.R3 - Dictyostelium discoideum An alternative non-animal model for developmental toxicity testing.PDF