Newswise — PHILADELPHIA—Jonathan A. Epstein, MD, executive vice dean and chief scientific officer of Penn Medicine, has received a National Heart, Lung, and Blood Institute (NHLBI) Outstanding Investigator Award. The highly competitive award provides long-term support to “an experienced investigator with an outstanding record of research productivity.” In issuing the award, the NHLBI, which is part of the National Institutes of Health, described Epstein as “an outstanding, pioneering investigator” and “a gold standard role model for physician-scientists in the field.”

Epstein, who is also the William Wikoff Smith Professor of Cardiovascular Research in the Perelman School of Medicine at the University of Pennsylvania, studies molecular mechanisms of cardiovascular development and stem cell biology, and their implications for understanding human disease.

The award will provide $6.7 million over seven years to investigate lineage determination and cell fate, a field of research that aims to understand how a single fertilized egg is transformed into the numerous specialized tissues that comprise the body. Specifically, using super-resolution imaging and CRISPR-related techniques, Epstein will visualize and examine gene locations in live cells, concentrating on understanding how the process that produces cardiac cells can be manipulated to potentially regenerate damaged cardiac tissue following heart attacks and other cardiac diseases. In granting its award, the NHLBI noted that this area of research has “broad importance in multiple cell types beyond cardiac cells,” including the brain and intestines.

A board-certified cardiologist, Epstein joined the Penn faculty in 1996. A graduate of Harvard College and Harvard Medical School, he completed his residency and fellowship in medicine and cardiology at the Brigham and Women’s Hospital, where he also completed a Howard Hughes Medical Institute postdoctoral fellowship in genetics. He and his laboratory colleagues have identified causes of and potential new therapies for congenital heart disease and adult heart failure, as well as uncovered basic signaling mechanisms that regulate stem-cell differentiation and quiescence (periods when a cell is not dividing). This work provides important clues for efforts to regenerate damaged organs, including the heart. Epstein is the author of more than 190 peer-reviewed articles in numerous journals, including Nature, Science, the New England Journal of Medicine, and Cell, as well as Harrison’s Principles of Internal Medicine, the leading textbook in the field.

Epstein is a member of the American Academy of Arts and Sciences, American Association of Physicians, past president of the Interurban Clinical Club and the American Society for Clinical Investigation, and a member of the National Academy of Medicine. He serves on several editorial boards and is a past deputy editor of the Journal of Clinical Investigation. He is a member of the NIH Council of Councils and the NIH Precision Medicine Initiative Cohort (“All of Us”) Program Advisory Committee. Epstein was a founding co-director of the Penn Institute for Regenerative Medicine in 2007.


Penn Medicine is one of the world's leading academic medical centers, dedicated to the related missions of medical education, biomedical research, and excellence in patient care. Penn Medicine consists of the Raymond and Ruth Perelman School of Medicine at the University of Pennsylvania (founded in 1765 as the nation's first medical school) and the University of Pennsylvania Health System, which together form a $6.7 billion enterprise.

The Perelman School of Medicine has been ranked among the top five medical schools in the United States for the past 20 years, according to U.S. News & World Report's survey of research-oriented medical schools. The School is consistently among the nation's top recipients of funding from the National Institutes of Health, with $392 million awarded in the 2016 fiscal year.

The University of Pennsylvania Health System's patient care facilities include: The Hospital of the University of Pennsylvania and Penn Presbyterian Medical Center -- which are recognized as one of the nation's top "Honor Roll" hospitals by U.S. News & World Report -- Chester County Hospital; Lancaster General Health; Penn Wissahickon Hospice; and Pennsylvania Hospital -- the nation's first hospital, founded in 1751. Additional affiliated inpatient care facilities and services throughout the Philadelphia region include Good Shepherd Penn Partners, a partnership between Good Shepherd Rehabilitation Network and Penn Medicine.

Penn Medicine is committed to improving lives and health through a variety of community-based programs and activities. In fiscal year 2016, Penn Medicine provided $393 million to benefit our community.