Newswise — The September 2019 issue of Toxicological Sciences features Tox Spotlight articles on chimney sweeps exposed to polycyclic aromatic hydrocarbons, the relationship between endocrine and renal findings in studies of the γ-secretase inhibitor Avagacestat, environmental exposure to phthalates during prostate development in rats, and the disruption of lipid homeostasis due to environmental chemicals in neonatal mouse brains. There also are Open Access articles on the adaptation of systematic review framework for assessing toxicity tests, using physiologically based kinetic modeling-facilitated reverse dosimetry to predict acetylcholinesterase inhibition, and the decontamination of hair following a hazmat incident.
Highlights of Toxicological Sciences Volume 171, Issue 1:
- TOX SPOTLIGHT “Multiomics Investigation Reveals Benzalkonium Chloride Disinfectants Alter Sterol and Lipid Homeostasis in the Mouse Neonatal Brain”
- TOX SPOTLIGHT “Exposure to an Environmentally Relevant Phthalate Mixture During Prostate Development Induces MicroRNA Upregulation and Transcriptome Modulation in Rats”
- TOX SPOTLIGHT “Investigations on the Relationship Between Ovarian, Endocrine, and Renal Findings in Nonclinical Safety Studies of the γ-Secretase Inhibitor Avagacestat”
- TOX SPOTLIGHT “Cardiovascular Disease-Related Serum Proteins in Workers Occupationally Exposed to Polycyclic Aromatic Hydrocarbons” (Open Access)
- OPEN ACCESS “Adaptation of the Systematic Review Framework to the Assessment of Toxicological Test Methods: Challenges and Lessons Learned with the Zebrafish Embryotoxicity Test”
- OPEN ACCESS “Physiologically Based Kinetic Modeling-Facilitated Reverse Dosimetry to Predict In Vivo Red Blood Cell Acetylcholinesterase Inhibition following Exposure to Chlorpyrifos in the Caucasian and Chinese Population”
- OPEN ACCESS “Decontamination and Management of Contaminated Hair following a CBRN or HazMat Incident”
Toxicological Sciences is the official journal of the Society of Toxicology (SOT), a professional and scholarly organization of more than 7,800 scientists from academic institutions, government, and industry representing the great variety of individuals who practice toxicology around the world.