Reducing Micropeptide Protein Expression May Prevent Cardiomyopathy in Duchenne Muscular Dystrophy

Article title: Sarcolipin haploinsufficiency prevents dystrophic cardiomyopathy in mdx mice

Authors: Satvik Mareedu, Ronald Pachon, Jayapalraj Thilagavathi, Nadezhda Fefelova, Rekha Balakrishnan, Nandita Niranjan, Lai-Hua Xie, Gopal J. Babu

From the authors: “Together these findings provide new mechanistic insights into the role of [sarcolipin] upregulation in the development of dystrophic cardiomyopathy as well as the therapeutic potential of targeting [sarcolipin] expression in preventing dystrophic cardiomyopathy.”

This study is highlighted as one of January’s "best of the best" as part of the American Physiological Society's APSselect program.