Newswise — Rockville, Md. (June 14, 2019)—Top renal experts will discuss current and cutting-edge research on kidney function at the upcoming American Physiological Society (APS)/American Society of Nephrology (ASN) Conference: Control of Renal Function in Health and Disease in Charlottesville, Va.

The conference will “assemble established leaders in renal and hypertension research with younger investigators and trainees to discuss novel causative mechanisms and potential therapeutic options,” said conference co-chair Edward Inscho, PhD, of the University of Alabama at Birmingham. “The casual meeting environment allows for trainees to get to know established investigators in the field, cultivate productive collaborations and forge new and lasting relationships with colleagues,” he added. Pablo Ortiz, PhD, of Henry Ford Hospital in Detroit is the conference co-chair.

Conference topics will include:

  • obesity, diabetes and metabolic syndrome;
  • sex steroids and the kidney;
  • developmental programming of kidney disease;
  • kidney genetics and epigenetics; and
  • immunology and circadian biology of kidney function.

The program will include research-based sessions, abstract-driven presentations and poster sessions.

Program Highlights

Sunday, June 23

Keynote Address: New Frontiers in Kidney Research: Overview of the Field

Chair: Pablo Ortiz, PhD, Henry Ford Hospital, Detroit

Speaker: Donald Kohan, MD, PhD, University of Utah

Monday, June 24

Session 1: Circadian biology of renal and cardiovascular function

Chair: Michelle Gumz, PhD, University of Florida


“Circadian influence on renal and cardiovascular function”

Martin Young, PhD, University of Alabama at Birmingham

“Control of sodium excretion and blood pressure by Bmal1 in rats”

Jermaine Johnston, PhD, University of Florida

“Endogenous circadian rhythms in blood pressure, aldosterone, and vascular function in health and disease”

Saurabh Thosar, PhD, Oregon Health Sciences University

Session 2: Renal consequences of obesity, metabolic syndrome and diabetes

Chair: Lilach Lerman, MD, PhD, Mayo Clinic, Rochester, Minn.


“Role of kidney insulin receptors in obesity and insulin resistance—journey from savory to sweet”

Vivek Bhalla, MD, PhD, Stanford University, Stanford, Calif.

“Insulin and glucose effects on renal Na handling”

Michael Brands, PhD, Augusta University, Augusta, Ga.

“Renal mitochondrial injury in swine metabolic syndrome”

Alfonso Eirin, MD, Mayo Clinic, Rochester, Minn.

Workshop on sex and gender as research variables

Chairs: Jennifer Sullivan, PhD, Augusta University, Augusta, Ga. and Michael Ryan, PhD, University of Mississippi Medical Center

Session 3: New signaling pathways in the control of renal function

Chair: Jennifer Pluznick, PhD, Johns Hopkins University School of Medicine, Baltimore


“Extra sensory perception: novel receptors and metabolites in renal and cardiovascular function”

Jennifer Pluznick, PhD, Johns Hopkins University School of Medicine, Baltimore

“A role for sweet taste receptors (T1R2/T1R3) in renal function and fructose-induced signaling in the kidney”

Pablo Ortiz, PhD, Henry Ford Hospital, Detroit

“Receptor mediated endocytosis in proximal tubule function”

Ora Weisz, PhD, University of Pittsburgh

“Renal glucose handling in health and disease: a case for olfactory receptor 1393”

 Blythe Shepard, PhD, Georgetown University, Washington, D.C.

Tuesday, June 25

Session 4: The new life of the JGA

Chair: Ruisheng Liu MD, PhD, University of South Florida


“New developments in macula densa cell function and imaging in vivo”

Janos Peti-Peterdi, PhD, University of Southern California

“Control of renin release in diabetes”

Mariela Mendez, PhD, Henry Ford Hospital, Detroit

“Novel integrative functions of the JG cells”

Vladimir Todorov, PhD, University Hospital Carl Gustav Carus, Technische Universität Dresden, Germany

Session 5: Immune system contributions to renal tubular transport, hemodynamics and hypertension Chair: Michael Hultström, MD, PhD, Uppsala University, Sweden


“New immune mechanisms in hypertension”

Hanna A. Itani, PhD, Vanderbilt University, Nashville, Tenn.

“TNF-alpha in the regulation of renal ion transport”

Nicholas Ferreri, PhD, New York Medical College

“Immune mechanisms of renal injury in salt-sensitive hypertension”

David Mattson, PhD, Medical College of Wisconsin

Session 6: The kidney and hypertension

Chair: Peter Bie, MD, PhD, University of Southern Denmark


“NCC and ENaC: Facebook friends or linked (in) together?”

Robert Hoover, MD, Emory University, Atlanta

“Basolateral Kir4.1/Kir5.1 potassium channels in salt handling and blood pressure control”

Alexander Staruschenko, PhD, Medical College of Wisconsin

“Afferent arteriolar ROS: Protectors or weak links for the kidney in hypertension and CKD?”

Chris Wilcox, MD, Georgetown University, Washington, D.C.

“The potassium switch in sodium metabolism and blood pressure”

Paul Welling, MD, University of Maryland

Wednesday, June 26

Session 7: Autacoids and prostaglandins in renal function and disease

Chair: Michal Schwartzman, PhD, New York Medical College


“New role of 20-HETE in renal hemodynamics and hypertension”

Victor Garcia, PhD, New York Medical College

“Autocrine actions of ET-1 on the renal medulla”

Kelly Hyndman, PhD, University of Alabama at Birmingham

“Function and significance of the nephron prorenin receptor”

Nirupama Ramkumar, MD, MPH, University of Utah

Session 8: Polycystic kidney disease: Biology of cystic kidney disorders

Chair: P. Darwin Bell, PhD, University of Alabama at Birmingham


“Insight into the pathogenesis of cystic kidney disorders from genetic studies”

Peter C. Harris, PhD, Mayo Clinic, Rochester, Minn.

“Cilia regulation of injury responses and connections with cystic kidney disease”

Bradley Yoder, PhD, University of Alabama at Birmingham

“Role of purinergic receptors and ENaC in cyst growth in PKD”

Tengis Pavlov, PhD, Henry Ford Hospital, Detroit

Session 9: Purinergics in kidney function and disease

Chair: Helle Praetorius, PhD, Aarhus University, Denmark


“Purinergic signaling in renal disease”

Matthew Bailey, PhD, The University of Edinburgh, Scotland

“P2 receptor-dependent regulation of medullary blood flow”

Claire M. Peppiatt-Wildman, PhD, Universities of Kent and Greenwich Chatham Maritime, England

“P2 receptor-mediated regulation of collecting duct function”

James Stockand, PhD, University of Texas Health Science Center at San Antonio

“P2 receptors in renal tubular transport”

Jens Leipziger, PhD, Aarhus University, Denmark

Session 10: Salt, genetics and epigenetics in kidney function

Chair: Timo Rieg, PhD, University of South Florida


“Single and multi-trait genome-wide association analyses in identifying kidney traits in selected populations”

Nora Franceschini, MD, MPH, The University of North Carolina at Chapel Hill

“MicroRNA mediators of renal injury and chronic reno-cardiac syndrome”

Alison Kriegel, PhD, Medical College of Wisconsin

“New concepts in the genetics of renin”

Ariel Gomez, MD, University of Virginia

Session 11: Causes and consequences of acute kidney injury

Chair: Pontus Persson, MD, Institut für Vegetative Physiologie, Germany

“Epithelial beta-catenin signaling in the AKI to CKD transition”

Leslie Gewin, MD, Vanderbilt University, Nashville, Tenn.

“Neural circuits controlling inflammation in acute kidney injury”

Mark Okusa, MD, University of Virginia

“Role of S1P signaling in renal ischemia-reperfusion injury”

Zhengrong Guan, MD, PhD, University of Alabama at Birmingham

More details about the meeting are available on the APS website.

NOTE TO JOURNALISTS: The 11th triennial APS/ASN Conference: Control of Renal Function in Health and Disease is formerly known as the Renal Hemodynamics Summer Research Conference. It will be held June 23–27 in Charlottesville, Va. To schedule an interview with the conference organizers or presenters, contact the APS Communications Office or 301.634.7314. Find more research highlights in the APS News Room.

Physiology is the study of how molecules, cells, tissues and organs function in health and disease. Established in 1887, the American Physiological Society (APS) was the first U.S. society in the biomedical sciences field. The Society represents more than 10,000 members and publishes 15 journals with a worldwide readership.

Meeting Link: APS/ASN Conference: Control of Renal Function in Health and Di