Newswise — Bethesda, Md. (August 22, 2017)—The American Physiological Society (APS) will host the “Physiological Bioenergetics: Mitochondria from Bench to Bedside” conference August 27–30 in San Diego. The meeting will bring together cross-disciplinary experts who study the mitochondria, which provide the energy to individual cells.  

“While mitochondria are traditionally known as the powerhouse of the cell, accumulating studies demonstrate that the shape, movement and function of these organelles control much more in the cell beyond energy levels,” Sruti Shiva, PhD, researcher at the University of Pittsburgh and chair of the conference organizing committee, said. “This conference brings together researchers investigating all aspects of mitochondrial function—how they regulate energy production, how changes in their shape change cell function, their control of cell death and more. These unique perspectives on the mitochondrion will be discussed in the context of how they contribute to human health and disease progression.”

Mitochondrial function is often studied within the context of a specific disease or organ system, but how these discoveries translate to predicting, modulating or treating disease is not always clear-cut. The goal of the conference is to bring together experts studying varied facets of this field of research across disciplines and in the context of different pathologies to share their most recent findings and to discuss strategies to further advance the field of “mitochondriology.”



Monday, August 28


Keynote Lecture: The Mitochondria Reticulum of Muscle Cells

Speaker: Robert Balaban, National Institutes of Health; National Heart, Lung and Blood Institute


Symposia I: Energy School I

Chair: Sruti Shiva, University of Pittsburgh


Mitochondrial Targeted Molecules: Tools and Therapy

Speaker: Dave Brown, Virginia Polytechnic Institute


The Ins and Outs of Mitophagy and Quality Control

Speaker: Roberta Gottlieb, Cedars-Sinai, Los Angeles


Symposia II: Moving Mitochondria—Networks and Quality Control

Chair: Shannon Bailey, University of Alabama at Birmingham


DRP1 Regulates Bioenergetics in the Heart

Speaker: Shey-Shing Sheu, Thomas Jefferson University


Functionalizing the Mitochondrial Proteome

Speaker: Jared Rutter, University of Utah


Mitochondrial Dynamics in the Brain

Speaker: Sarah Berman, University of Pittsburgh Medical Center


Mito Dynamics in Muscle Pathophysiology

Speaker: David Chan, California Institute of Technology


Symposia III: Translating the Mitochondria—Taking It to the Clinic

Chair: Roberta Gottlieb, Cedars-Sinai, Los Angeles


Muscle Bioenergetics in Exercise and Bed Rest

Speaker: Bret Goodpaster, The Translational Research Institute


Platelet Bioenergetics as a Biomarker of Disease

Speaker: Sruti Shiva, University of Pittsburgh


Mitochondrial DNA Damage as a Blood-based Biomarker for Early Parkinson’s Disease

Speaker: Laurie Sanders, Duke University


Bioenergetics of Circulating Cells in Disease

Speaker: Victor Darley-Usmar, University of Alabama at Birmingham


Tuesday, August 29


Symposia IV: Energy School II

Chair: Victor Darley-Usmar, University of Alabama at Birmingham


The Basics of Substrate Switching

Speaker: Nika Danial, Harvard Medical School


MtDNA Structure and Signaling

Speaker: Scott Ballinger, University of Alabama at Birmingham


Symposia V: Mitochondrial Adaptations and Responses to Stress

Chair: Nika Danial, Harvard Medical School


Targeting Intracellular NAD(H) Level to Improve Mitochondrial Stress Response

Speaker: Rong Tian, University of Washington


Mitochondrial Acetylation in Heart Failure

Speaker: Iain Scott, University of Pittsburgh


Mechanisms of Mitochondrial Redox Control over Adipose Tissue Function

Speaker: Ed Chouchani, Harvard Medical School


Increased Mitochondrial Oxidative Stress Does Not Cause Muscle Atrophy

Speaker: Holly Van Remmen, Oklahoma Medical Research Foundation


The Phosphate Carrier and Bioenergetics

Speaker: Erin Seifert, Thomas Jefferson University


Symposia VI: Mitochondrial Signaling: ATP and Beyond

Chair: Holly Van Remmen, Oklahoma Medical Research Foundation


Mitochondrial ROS in Neuronal Signaling

Speaker: Andrew Wojtovich, University of Rochester Medical Center


Mitochondrial Redox Signaling

Speaker: Navdeep Chandel, Northwestern University


Mitochondrial Protein Import and Signaling

Speaker: Carla Koehler, University of California, Los Angeles


The Release of Mitochondria as DAMPs

Speaker: Eric Bollard, CHU de Quebec, Canada


Mitochondrial Signaling in Myofibroblast Transdifferentiation and Fibrosis

Speaker: John Elrod, Temple University


Wednesday, August 30


Symposia VII: Mitochondrial Genetics and OMICs

Chair: Scott Ballinger, University of Alabama at Birmingham


Novel Methods of mtDNA Modulation

Speaker: Carlos Moraes, University of Miami


Mito-Nuclear Signaling in Aging

Speaker: Aditi Gurkar, Scripps Research Institute–Florida


Mitochondrial Function and the Epigenetic Landscape

Speaker: Janine Santo, National Institutes of Health, National Institute of Environmental Health Sciences


Mitochondrial Targeted Oxidants and DNA Damage

Speaker: Ben Van Houten, University of Pittsburgh


Mitochondrial Proteomics in the Heart

Speaker: Jennifer Van Eyk, Cedars-Sinai, Los Angeles


NOTE TO JOURNALISTS: The Physiological Bioenergetics: Mitochondria from Bench to Bedside conference will be held in San Diego, August 27–30. Read the full program. To schedule an interview with the conference organizers or presenters, contact the APS Communications Office or call 301-634-7209. Find more research highlights in the APS Press Room.


Physiology is the study of how molecules, cells, tissues and organs function in health and disease. Established in 1887, the American Physiological Society (APS) was the first U.S. society in the biomedical sciences field. The Society represents more than 10,500 members and publishes 15 peer-reviewed journals with a worldwide readership.


Meeting Link: Physiological Bioenergetics: Mitochondria from Bench to Bedside