Research Alert

Newswise — Article title: Glucocorticoids and serum- and glucocorticoid-inducible kinase 1 are potent regulators of CFTR in the native intestine: implications for stress-induced diarrhea

Authors: Md Kaimul Ahsan, Leandra Figueroa-Hall, Vanessa Baratta, Rolando Garcia-Milian, TuKiet T. Lam, Kazi Hoque, Pedro J. Salas, Nadia A. Ameen

From the authors: "This is the first study to examine the mechanisms of glucocorticoid, serum- and glucocorticoid-inducible kinase 1, and nongenomic kinase signaling of CFTR in the native intestine. We identified unique and druggable intestine-specific factors of the pathway that are targets for treating stress-induced diarrhea."

This study is highlighted as one of August’s "best of the best" as part of the American Physiological Society's APSselect program.


Journal Link: American Journal of Physiology - Gastrointestinal and Liver Physiology