Newswise — BOSTON (August 8, 2016)—A new paper from researchers from Tufts University and colleagues addresses how increased support for minority-focused research, community-based participatory research, and studies of gene-environment interactions may improve science’s understanding of chronic diseases across races and ethnicities. The paper, published in the August issue of Health Affairs, outlines policy efforts needed to ensure the advancement of genetic applications in healthcare in ways that reduce existing disparities.
Focusing on breast cancer and chronic kidney disease, the authors show that while genetic and molecular knowledge has grown and been used to fight these diseases in the last decade, significant racial and ethnic health disparities persist and hinder universal progress. The policy recommendations they propose are:
• Increasing the enrollment of non-white participants in research on complex diseases.• Community-based participatory research to promote genetic literacy and encourage more volunteers to become involved in research.• Funding research on the interactions of genes and the environment.• Educating healthcare providers as well as patients about the risks, benefits and limitations of genetic research.
“We need to collect more data from groups for whom we currently have insufficient information so that we can improve care for all individuals. If we don’t expand our efforts, the quality and effectiveness of genetic research and services will be limited in ways that can perpetuate health disparities. The Precision Medicine Initiative for one will be a big step forward in this endeavor and is to be commended for including community-based health provider organizations in its network to attract volunteers. Increasing diversity in research and testing will help maximize the possibilities of precision medicine,” said senior author José M. Ordovás, Ph.D., director of the Nutrition and Genomics Laboratory at the Jean Mayer USDA Human Nutrition Research Center on Aging at Tufts University.
The authors identify three key areas where their recommendations would make improvements: incomplete genetic databases, inadequate treatment options, and insufficiently understood disease mechanisms.
People with non-European ancestries are underrepresented in genetic databases, limiting the ability to apply genetic knowledge to reduce disease in these groups. While researchers know that hereditary breast cancer is linked to mutations in the BRCA1 or BRCA2 genes, the “normal” genetic sequence for these genes was determined based on women of European and Ashkenazi Jewish descent. Studies show that African-American and Hispanic women are much less likely than white women to receive genetic counseling or testing for hereditary breast cancer; the absence of this data perpetuates an incomplete genetic database on which clinical decisions about treating breast cancer rely.
For many diseases, clinical advances in treatment have developed based on new knowledge of genetic markers. Studies show that non-Hispanic black women tend to be diagnosed with more advanced sporadic breast cancer (occurring without family history) compared to white women. Many potential genetic markers might explain the racial and ethnic disparity in tumor aggressiveness in sporadic cancer. However, the small number of tumor samples from non-European women offers inadequate details about patient and tumor characteristics and restricts the use of genetic knowledge in clinical treatments for all individuals.
Similarly, treatments tailored to individuals with high-risk genotypes for certain diseases have not yet been identified because the molecular mechanisms behind the diseases are unknown as well. Researchers know that African-Americans are disproportionately affected by variants in the APOL1 gene which can increase a person’s risk of kidney disease by up to seven times. Due to insufficient understanding of the molecular mechanisms by which the gene increases disease risk, effective treatments elude clinicians.
“Ultimately, we want the knowledge gained from a reduction in health disparities to lead to an increase in treatments for people who are most at risk. If we understand the aggressive breast cancer subtype that more frequently affects black women, we might be able to expand treatment options. We want to look at environmental factors as well as tumor biology to know how they contribute to the disease, and how we might then attack it,” said first author Caren E. Smith, D.V.M., a scientist in the Nutrition and Genomics Laboratory at the Jean Mayer USDA Human Nutrition Research Center on Aging at Tufts University.
Additional authors of this paper are Stephanie M. Fullerton, associate professor at the University of Washington, in Seattle; Keith A. Dookeran, assistant professor at the School of Public Health at the University of Illinois at Chicago and chair and CEO of the Cancer Foundation for Minority and Underserved Populations; Heather Hampel, professor at the Ohio State University Comprehensive Cancer Center in Columbus; Adrienne Tin, assistant scientist at the Johns Hopkins Bloomberg School of Public Health in Baltimore, Maryland; Nisa M. Maruthur, assistant professor at the Johns Hopkins University School of Medicine, the department of epidemiology at the Johns Hopkins Bloomberg School of Public Health, and the Welch Center for Prevention, Epidemiology, and Clinical Research at Johns Hopkins University; Jonathan C. Schisler, assistant professor at the University of North Carolina at Chapel Hill; Jeffrey A. Henderson, president and CEO of the Black Hills Center for American Indian Health in Rapid City, South Dakota; and Katherine L. Tucker, professor at the University of Massachusetts Lowell.
The authors of the paper were supported by the Centers for Population Health and Health Disparities grants from the National Cancer Institute and the National Heart, Lung, and Blood Institute (NHLBI) of the National Institutes of Health (award numbers P50CA148143, P50CA148596, P50HL105187, P50HL105185, P50CA105632, P50HL105189, P50HL105188, P50CA106743, P50HL105184, P50CA148110). In addition, Caren Smith was supported by the NHLBI (award number K08HL112845); Keith Dookeran by the Komen Foundation and the Cancer Foundation for Minority and Underserved Populations; and Adrienne Tin by the Renal Disease Epidemiology Training Program at the National Institute of Diabetes and Digestive and Kidney Diseases (award number T32DK007732).
Smith, C.E., Fullerton S.M., Dookeran K.A., Hampel H., Tin A., Maruthur N.M., Schisler J.C., Henderson .JA., Tucker K.L., and Ordovas J.M., “Using genetic technologies to reduce, rather than widen, health disparities,” Health Affairs. 2016; 35(8):1367-1373. doi:10.1377/hlthaff.2015.1476
About the Jean Mayer USDA Human Nutrition Research Center on Aging and the Friedman School of Nutrition Science and Policy For three decades, the Jean Mayer USDA Human Nutrition Research Center on Aging at Tufts University has studied the relationship between good nutrition and good health in aging populations. Tufts research scientists work with federal agencies to establish the USDA Dietary Guidelines for Americans, the Dietary Reference Intakes, and other significant public policies. The Gerald J. and Dorothy R. Friedman School of Nutrition Science and Policy at Tufts University is the only independent school of nutrition in the United States. The school’s eight degree programs – which focus on questions relating to nutrition and chronic diseases, molecular nutrition, agriculture and sustainability, food security, humanitarian assistance, public health nutrition, and food policy and economics – are renowned for the application of scientific research to national and international policy.
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