Research Alert

Article title: Demonstration of age-related blood-brain barrier disruption and cerebromicrovascular rarefaction in mice by two-photon microscopy and optical coherence tomography

Authors: Ádám Nyúl-Tóth, Stefano Tarantini, Jordan Delfavero, Feng Yan, Priya Balasubramanian, Andriy Yabluchanskiy, Chetan Ahire, Tamas Kiss, Tamas Csipo, Agnes Lipecz, Attila E Farkas, Imola Wilhelm, István A Krizbai, Qinggong Tang, Anna Csiszar, Zoltan I Ungvari

From the authors: “Methods for longitudinal detection of age-related increases in blood-brain barrier permeability and microvascular rarefaction in the mouse cerebral cortex by intravital two-photon microscopy and optical coherence tomography are presented.” 

This study is highlighted as one of April’s "best of the best" as part of the American Physiological Society's APSselect program.


Journal Link: American Journal of Physiology-Heart and Circulatory Physiology