Sacubitril and Valsartan Combination Treatment May Reduce Hypertensive Kidney Disease

Newswise — Article title: Differential effects of low-dose sacubitril and/or valsartan on renal disease in salt-sensitive hypertension

Authors: Iuliia Polina, Mark Domondon, Rebecca Fox, Anastasia V. Sudarikova, Miguel Troncoso, Valeriia Y. Vasileva, Yuliia Kashyrina, Monika Beck Gooz, Ryan S. Schibalski, Kristine Y. DeLeon-Pennell, Wayne R. Fitzgibbon, Daria V. Ilatovskaya

From the authors: “Our study opens new possibilities and sets the stage to explore if low-dose combination treatment could have clinical benefits for [salt-sensitive] individuals. However, there is a need for more research studies and higher dosing, in different animal models and diverse genetic backgrounds, to completely close the existing gap in knowledge.” 

This study is highlighted as one of August’s "best of the best" as part of the American Physiological Society's APSselect program.