Research Alert

Article title: Elevated cerebrospinal fluid sodium in hypertensive human subjects with a family history of Alzheimer’s disease

Authors: Lucas A. C. Souza, Fatima Trebak, Veena Kumar, Ryousuke Satou, Patrick G. Kehoe, Wei Yang, Whitney Wharton, Yumei Feng Earley

From the authors: "Our data show a significant increase in [cerebrospinal fluid [Na+], but not plasma [Na+], in [hypertension] patients with a family history of [Alzheimer’s disease] that is positively correlated with [blood pressure], suggesting the potential importance of [cerebrospinal fluid] Na+, but not plasma Na+, in the development or maintenance of chronic human hypertension. Our findings thus support the biological plausibility of a functional relationship between high sodium in the [cerebrospinal fluid] and arterial pressure in humans, although the underlying mechanisms remain to be determined."

This study is highlighted as one of March's "best of the best" as part of the American Physiological Society's APSselect program.

 

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