Newswise — PHILADELPHIA —The University of Pennsylvania’s Institute for Regenerative Medicine will host a symposium on Friday, April 11, 2014 to detail the progress researchers are making toward reprogramming human cells to treat a variety of diseases.

In addition to talks on the basic science of regenerative medicine, Nobel laureate John Gurdon will present the keynote address entitled, “Past, Present and Future Prospects for Nuclear Reprogramming by Amphibian Eggs and Oocytes,” and New York Times reporter Nicholas Wade will speak about “Regenerative Medicine: Promises and Perils.”

When: Friday, April 11, 2014, 8:30am – 5:00pm

Where: BRB Auditorium, 421 Curie Blvd, Philadelphia, PA 19104

What: Agenda and other details can be found on the IRM web site.

Symposium schedule:

8:30 Introduction and Welcome J. Larry Jameson, MD, PhDExecutive Vice-President, University of Pennsylvania for the Health System Dean, Perelman School of MedicineJohn Gearhart, PhDDirector, Institute for Regenerative Medicine 8:45 Keynote: Past, Present and Future Prospects for Nuclear Reprogramming by Amphibian Eggs and OocytesJohn Gurdon, FRS, FMedSci 2012 Nobel Laureate in Physiology and Medicine Wellcome Trust/Cancer Research UK Gurdon Institute The Henry Wellcome Building of cancer and Developmental Biology 9:45 Progress Towards Instructing Our Cells for Therapies John Gearhart, PhD

10:00 BREAK

10:15 Session 1: PluripotencyChair: Jon Epstein, MD Chair, Department of Cell and Developmental Biology 10:20 Dissecting the Steps of Reprogramming to Pluripotency Kathrin Plath, PhD Associate Professor, Department of Biological Chemistry University of California – Los Angeles11:00 Mechanisms of Cellular Programming and Reprogramming Ken Zaret, PhD Professor, Cell and Developmental Biology Associate Director, Institute for Regenerative Medicine 11:35 Regenerative Medicine: Promises and PerilsNicholas Wade Science Journalist and AuthorNew York Times


1:00 Session 2: Developmental BiologyChair: Chris Lengner, PhDAssistant ProfessorAnimal Biology, School of Veterinary Medicine Cell and Developmental Biology, Perelman School of Medicine1:05 Hematopoietic Stem Cell Formation – Lessons from the Embryo Nancy Speck, PhD Professor, Cell and Developmental Biology1:45 Functional Single Cell Genomics: The Importance of Variability James Eberwine, PhD Professor of Pharmacology Co-Director, Penn Genome Frontiers Institute

2:25 BREAK

2:40 Session 3: Reprogramming Cell FatesChair: Nancy Speck, PhD2:45 Experimental and (Patho)physiological Reprogramming in the Adult Liver Kilang Yanger, PhD Postdoctoral Fellow, Department of Medicine 3:10 Transdifferentiation of Fibroblasts to Cardiomyocytes Russ Addis, PhD Sr. Research Investigator, Cell and Developmental Biology 3:40 Hair Follicle Stem Cells and Skin Regeneration George Cotsarelis, MD Chair, Department of Dermatology

4:20 Final Discussion on Cellular ReprogrammingKen Zaret, PhD


Penn Medicine is one of the world's leading academic medical centers, dedicated to the related missions of medical education, biomedical research, and excellence in patient care. Penn Medicine consists of the Raymond and Ruth Perelman School of Medicine at the University of Pennsylvania (founded in 1765 as the nation's first medical school) and the University of Pennsylvania Health System, which together form a $4.3 billion enterprise.

The Perelman School of Medicine has been ranked among the top five medical schools in the United States for the past 17 years, according to U.S. News & World Report's survey of research-oriented medical schools. The School is consistently among the nation's top recipients of funding from the National Institutes of Health, with $392 million awarded in the 2013 fiscal year.

The University of Pennsylvania Health System's patient care facilities include: The Hospital of the University of Pennsylvania -- recognized as one of the nation's top "Honor Roll" hospitals by U.S. News & World Report; Penn Presbyterian Medical Center; Chester County Hospital; Penn Wissahickon Hospice; and Pennsylvania Hospital -- the nation's first hospital, founded in 1751. Additional affiliated inpatient care facilities and services throughout the Philadelphia region include Chestnut Hill Hospital and Good Shepherd Penn Partners, a partnership between Good Shepherd Rehabilitation Network and Penn Medicine.

Penn Medicine is committed to improving lives and health through a variety of community-based programs and activities. In fiscal year 2013, Penn Medicine provided $814 million to benefit our community.

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