Tackling Liver Injury

Newswise — A new drug spurs liver regeneration after surgery, according to a paper published in The Journal of Experimental Medicine.

Liver cancer often results in a loss of blood flow and thus oxygen and nutrients to the liver tissue, resulting in deteriorating liver function. Although the diseased part of the liver can often be surgically removed, the sudden restoration of blood flow to the remaining liver tissue can trigger inflammation—a process known as ischemia reperfusion injury (IRI). IRI results in part from the deposition of immune proteins called complement on the surface of liver cells, causing them to die and thus impairing liver regeneration.

Complement inhibitors effectively dampen IRI, but the benefits of this approach come at a cost, as certain complement proteins are also required for liver tissue to regrow. A group of scientists at the Medical University of South Carolina now show that a novel complement inhibitor reduces complement-mediated liver cell death and actually stimulates post-surgery liver regrowth in mice. The novel inhibitor limited the deposition of complement proteins and promoted the division of new liver cells. Even after removal of as much as 90% of the liver, treatment increased survival from 0% in untreated animals to an impressive 70%.

The selectivity of this novel complement inhibitor, and its unexpected ability to promote liver regeneration, suggests that it might represent a new treatment strategy for a variety of liver injuries in humans.

Marshall, K.M., et al. 2014. J. Exp. Med. doi:10.1084/jem.20131902 About The Journal of Experimental MedicineThe Journal of Experimental Medicine (JEM) is published by The Rockefeller University Press. All editorial decisions on manuscripts submitted are made by active scientists in conjunction with our in-house scientific editors. JEM content is posted to PubMed Central, where it is available to the public for free six months after publication. Authors retain copyright of their published works and third parties may reuse the content for non-commercial purposes under a creative commons license. For more information, please visit www.jem.org .

Research reported in the press release was supported by the National Institutes of Health, the National Natural Science Foundation of China, Guangxi Natural Science Foundation, the Science & Technology Planning Project of Guangxi Province, and the Science & Technology Planning Project of Guilin City.