Newswise — TORONTO – May 6, 2019 – For patients with aortic stenosis that cannot be treated with medication, surgical (SAVR) and transcatheter (TAVR) aortic valve replacement can offer effective treatment.  A new study, one of two on the topic released today at the American Association for Thoracic Surgery’s 99thAnnual Meeting, examines, for the first time, the effects of TAVR with a balloon-expandable valve for low-risk patients.

950 patients with severe symptomatic aortic stenosis and low surgical risk participated in the randomized trial.  At 30 days, results favored TAVR with a balloon-expandable valve, with fewer deaths (0.4 percent vs. 1.1 percent); fewer strokes (0.6 percent vs. 2.4 percent); and fewer re-hospitalizations (3.4 percent vs. 6.5 percent.) These differences were maintained at one year. In addition, 30-day rates of life-threatening bleeding were lower (3.6 percent vs. 24.5 percent), as was new onset atrial fibrillation (5.0 percent vs. 29.5 percent.) 

Patients treated with TAVR also experienced other benefits.  Length of stay in the ICU and duration of hospital stay were both significantly decreased, with 96 percent of those treated with TAVR discharged to home or self-care vs. 73 percent of SAVR patients. 

“While previous studies have focused on patients with higher surgical risk, almost 80 percent of patients who are operated upon for aortic stenosis fall into the low risk category,” explained lead author Martin Leon, Director, Center for Interventional Vascular Therapy at New York-Presbyterian/ Columbia University Medical Center and Founder and Chairman Emeritus of the Cardiovascular Research Foundation (CRF). “Significantly, the data shows that for low risk patients, the two therapies – SAVR and TAVR – are at least equivalent, and in many cases, TAVR may be the preferred alternative. The study will continue to follow patients to 10 years, which will also provide important data on the durability of these balloon expandable valves.”

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Notes for Editors:

The PARTNER 3 Low-Risk TAVR Trial: Detailed Analysis of Primary Endpoint Components and Key Secondary Endpoints

Martin B. Leon, Michael J. Mack, Maria C. Alu, Raj Makkar, Vinod Thourani, Susheel Kodali, Samir Kapadia, Wilson Szeto, Mark Russo, Mathew R. Williams, S. Chris Malaisrie, Philippe Pibarot, Scott Goldman, John Webb, David J. Cohen, and Craig R. Smith


Presented by Martin Leon, MD, Monday, May 6, 2019 at the AATS 99th Annual Meeting.


The American Association for Thoracic Surgery (AATS) is an international organization that encourages, promotes, and stimulates the scientific investigation of cardiothoracic surgery. Founded in 1917 by a respected group of the earliest pioneers in the field, its original mission was to “foster the evolution of an interest in surgery of the Thorax.” Today, the AATS is the premiere association for cardiothoracic surgeons in the world and works to continually enhance the ability of cardiothoracic surgeons to provide the highest quality of patient care. Its more than 1500 members have a proven record of distinction within the specialty and have made significant contributions to the care and treatment of cardiothoracic disease. Visit to learn more. 

Meeting Link: American Association for Thoracic Surgery’s 99th Annual Meeting