Uncovering the Emergence of HSCs in the Human Fetal Bone Marrow by Single-Cell RNA-Seq Analysis

Newswise — Zheng et al. provide a transcriptomic landscape of hematopoietic stem and progenitor cells and microenvironment in human fetal bone marrow and spleen. They uncover the precise timepoint at which hematopoietic stem cells (HSCs) seed fetal bone marrow and key niche cells and ligand-receptor interactions involved in the human HSC colonization.