Animal Trial to Test Promising Vaccine for H1N1

If results positive, vaccine could be available to pig farmers by end of year


  • newswise-fullscreen Animal Trial to Test Promising Vaccine for H1N1

    Credit: University of Nebraska Medical Center

    Sam Sanderson, Ph.D., is working on an H1N1 vaccine that could be available to pig farmers by the end of this year.

  • newswise-fullscreen Animal Trial to Test Promising Vaccine for H1N1

    Samer Al-Murrani, Ph.D., is serving as interim CEO of the company manufacturing the H1N1 vaccine that is being tested in pigs.

Newswise — Omaha Neb. — An H1N1 vaccine developed at the University of Nebraska Medical Center will enter a definitive round of testing this month, and researchers hope to establish its ability to ward off the virus.

Made possible by a licensing deal brokered through UNMC's technology transfer office, UNeMed Corporation, the study will evaluate the vaccine on 30-40 pigs.

If tests yield results as expected, Prommune, Inc. could begin offering an H1N1 vaccine to hog farmers as early as the end of the year, although full approval from the USDA would likely take another three or four years.

Ultimately, an H1N1 vaccine as potentially effective as Prommune's could dramatically diminish the virus as a global threat to the world's pig population and could even lead to more effective vaccines for similar diseases in birds and perhaps humans.

Prommune, Inc. was built around the research of Sam Sanderson, Ph.D., who founded the company in 2002. Sanderson is currently a research associate professor of pharmaceutical science in the UNMC College of Pharmacy.

Sanderson's technology essentially helps activate and direct the immune system into a more targeted and efficient attack against invading pathogens.

The technology, an immune stimulating peptide called EP67, is a "platform technology" that is so versatile it can be tweaked and modified to work against a number of ailments and in a wide variety of animals.

In addition to the H1N1 vaccine, EP67 could have applications against different varieties of the avian flu virus, antibiotic-resistant bacteria, and other infectious agents.

But long before Prommune can develop anything for human use, researchers still need to compile years of data – beginning with the planned trials in coming weeks, said Prommune's interim CEO Samer Al-Murrani, Ph.D.

Al-Murrani joined Prommune in March, after first meeting Sanderson at an animal health investment forum in Kansas City back in 2013.

Al-Murrani, who has a background in animal health and holds a doctorate in immunology and biochemistry, said a platform technology like EP67 would intrigue investors and strategic partners. Several recent initial public offerings in the animal health sector didn't compare well to Prommune's innovative technology, he said.

"I think Prommune today has more product and market potential than any of those companies," he said.

Al-Murrani is the chief executive officer of Babylon BioConsulting, a firm based in Cheyenne, Wyo., which specializes in bringing early-stage technologies to biomedical markets.

Since signing on with Prommune in March, Al-Murrani has helped Prommune build a corporate structure, negotiated the licensing deal with UNeMed and established a strategic alliance with a nationally renowned animal testing facility that helped open the door to the upcoming trial.

About Prommune Inc.:Prommune is a research and development company that has created a unique and patented means to safely and effectively awaken the body’s own natural immune defenses without inflammatory side-effects. Such immune activation is possible through the use of novel immune stimulatory peptides, which are derived from a naturally-occurring protein component of the immune system. The use of these host-derived immune stimulatory peptides provides a broad therapeutic platform enabling the treatment of normal and antibiotic-resistant infections and the rapid generation a huge variety of new vaccines for human and veterinary medicine.

About Babylon BioConsulting:Babylon BioConsulting LLC is a full service human and animal health consulting firm, specializing in startup, pre-revenue and early stage valuation of animal health, biotechnology and drug development companies. Babylon services include investor outreach, due diligence, market research and business development, intangible asset valuation and management and executive interim management services. Additionally, the company performs human and animal health product development and scientific consulting services. The company’s interest and passion is to leverage its extensive experience and network of professionals within the human and animal health fields to help businesses accomplish their goals more efficiently, cost-effectively and in a timely manner.

About UNeMed:UNeMed Corporation is the technology transfer and commercialization office (TTO) for the University of Nebraska Medical Center. UNeMed serves all UNMC researchers, faculty and staff who develop new biomedical technology and inventions, and strives to help bring those innovations to the marketplace.

We are Nebraska Medicine and UNMC. Our mission is to lead the world in transforming lives to create a healthy future for all individuals and communities through premier educational programs, innovative research and extraordinary patient care.

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